Trimethylolpropane Hydroxypropyl Bis-Hydroxyethylamine Dendrimer: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Trimethylolpropane Hydroxypropyl Bis-Hydroxyethylamine Dendrimer?

Trimethylolpropane Hydroxypropyl Bis-Hydroxyethylamine Dendrimer is a lab-made, tree-like polymer created by reacting trimethylolpropane with hydroxypropyl bis-hydroxyethylamine in several controlled steps. Each reaction adds new branches, giving the molecule many tiny arms that can grab onto other substances. Because it is built from common alcohol-based building blocks, it is considered stable, water-friendly and easy to blend into modern skincare formulas.

The technology behind dendrimers was first explored in the late 1970s as chemists searched for highly branched molecules that could carry or bind ingredients more efficiently than straight-chain polymers. Cosmetic chemists later adopted these structures for their ability to boost product stability and rinse-off performance without heavy feel. Today this particular dendrimer is produced in specialized reactors where temperature, pH and reaction time are tightly controlled, then purified to remove any unreacted material before it reaches the formulation lab.

You are most likely to find Trimethylolpropane Hydroxypropyl Bis-Hydroxyethylamine Dendrimer in rinse-off cleansers, micellar waters, exfoliating masks, clarifying shampoos, anti-pollution moisturizers and other products that promise a fresh, residue-free finish.

Trimethylolpropane Hydroxypropyl Bis-Hydroxyethylamine Dendrimer’s Cosmetic Benefits/Uses

This ingredient serves more than one job in a formula, helping both the product and your skin perform at their best.

  • Chelating: It binds to metal ions like calcium and iron that may lurk in tap water or raw materials. Removing these metals keeps the formula stable, prevents discoloration and lets cleansing agents foam and rinse more effectively.
  • Cleansing: Its branched structure helps lift away dirt, oil and product buildup. It supports the main surfactants, allowing a gentle yet thorough cleanse that leaves skin and hair feeling smooth rather than stripped.

Who Can Use Trimethylolpropane Hydroxypropyl Bis-Hydroxyethylamine Dendrimer

This dendrimer is considered friendly for most skin types, including oily, combination, normal and dry complexions. Its lightweight cleansing action helps remove buildup without rough surfactants, making it gentle enough for sensitive skin as well. There are no reports of it clogging pores, so acne-prone users usually tolerate it.

The molecule is fully synthetic and contains no animal-derived raw materials, so it is suitable for vegans and vegetarians.

Current safety data show no specific risks for women who are pregnant or breastfeeding when the ingredient is used as directed in rinse-off or leave-on products. Still, this is not medical advice and anyone who is expecting or nursing should review new skincare with a qualified healthcare professional.

Trimethylolpropane Hydroxypropyl Bis-Hydroxyethylamine Dendrimer does not increase the skin’s sensitivity to sunlight, so there is no added need for extra daytime protection beyond the usual recommendation to wear sunscreen.

Potential Side Effects/Adverse Reactions

Reactions to topical Trimethylolpropane Hydroxypropyl Bis-Hydroxyethylamine Dendrimer differ from person to person. The points below outline potential side effects, yet these remain uncommon when the ingredient is formulated and used correctly.

  • Transient redness or mild stinging in very reactive or compromised skin
  • Contact dermatitis in individuals with a specific sensitivity to polyols or amine-based compounds
  • Eye irritation if high concentrations of a cleanser accidentally enter the eyes

If you notice persistent irritation or any unexpected reaction, stop using the product and seek advice from a medical professional.

Comedogenic Rating

Rating: 0 (non-comedogenic)

Trimethylolpropane Hydroxypropyl Bis-Hydroxyethylamine Dendrimer is a large, water-friendly polymer that stays mostly on the surface of skin and is designed to rinse away easily. Because it is hydrophilic and not oil based, it does not lodge inside pores or mix with sebum, so the chance of it triggering blackheads or breakouts is minimal. This makes it a comfortable choice for people prone to acne or congestion.

Only the overall formula matters: if the product also contains heavy oils or waxes, those ingredients—not the dendrimer—could still clog pores.

Summary

Trimethylolpropane Hydroxypropyl Bis-Hydroxyethylamine Dendrimer is a multitasking chelator and cleanser. Its branched structure traps troublesome metal ions to keep formulas fresh, then helps lift away dirt and excess oil for a thorough yet gentle clean. Although it brings real value to modern skincare, it is still a niche ingredient that shows up mainly in innovative cleansers, micellar waters and anti-pollution products rather than everyday moisturizers.

Current data show it is low risk for irritation, non-comedogenic and vegan friendly, so most users can enjoy its benefits with confidence. As with any new cosmetic, a quick patch test is a smart step before adding a product to your regular routine.

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