What Is Tripeptide-49 Oligopeptide-91 Dipeptide-19 R-Bovine Octapeptide-1?
Tripeptide-49 Oligopeptide-91 Dipeptide-19 R-Bovine Octapeptide-1 is a lab designed peptide made up of 34 amino acids strung together in a single chain. Scientists created it by fusing the genetic codes for four shorter peptides, then inserting that combined gene into a harmless strain of E. coli. During fermentation the bacteria act like miniature factories, producing large amounts of the fusion peptide. After fermentation the peptide is filtered, purified and dried into a fine powder that is easy to add to creams or serums.
The idea of blending multiple peptide sequences into one started in the early 2000s when cosmetic researchers were looking for ways to copy the skin-friendly parts of natural proteins without using animal sources. By joining the sequences of Tripeptide-49, Oligopeptide-91, Dipeptide-19 and the well studied R-Bovine Octapeptide-1, they hoped to deliver a broader range of skin benefits in one molecule. Its use quickly spread through high-end skin care labs because it is stable in water-based formulas and can be made on demand, keeping costs reasonable.
Today you will most often see Tripeptide-49 Oligopeptide-91 Dipeptide-19 R-Bovine Octapeptide-1 in lightweight anti-aging serums, hydrating lotions, sheet masks, eye creams and post-treatment soothing gels. Brands choose it when they want a gentle ingredient that can give skin a smoother, more comfortable feel without heavy oils or silicones.
Tripeptide-49 Oligopeptide-91 Dipeptide-19 R-Bovine Octapeptide-1’s Cosmetic Benefits/Uses
This ingredient is classified as a skin conditioning agent, meaning its main benefit is to keep the surface of the skin soft, smooth and healthy looking. In a formula it helps attract and hold moisture, supports a supple texture and can make skin feel calmer after stress such as exfoliation or environmental exposure. Regular use may lead to a more even appearance and improved comfort, which is why it has become popular in daily moisturizers and targeted serums.
Who Can Use Tripeptide-49 Oligopeptide-91 Dipeptide-19 R-Bovine Octapeptide-1
This peptide is considered gentle and non comedogenic so it can suit dry, oily, combination and sensitive skin. Its water based nature means it adds conditioning benefits without the heaviness that sometimes bothers acne prone or very oily complexions. People with an established allergy to peptides or fermentation derived ingredients should avoid it as a precaution because even low irritation actives can trigger a response in those cases.
Although the name mentions “bovine” the molecule is made entirely through bacterial fermentation, not animal tissue, making it acceptable for vegans and vegetarians. Brands that follow strict cruelty free standards often highlight this point in their marketing.
There is no research suggesting topical use of this peptide poses a risk during pregnancy or breastfeeding. Still this is not medical advice and anyone who is pregnant or nursing should show the full ingredient list of any product they plan to use to their doctor just to be safe.
The peptide does not heighten photosensitivity so it can be applied morning or night. As with most lightweight actives it layers well under sunscreen and makeup and does not conflict with vitamin C, retinoids or exfoliating acids.
Potential Side Effects/Adverse Reactions
Reactions to Tripeptide-49 Oligopeptide-91 Dipeptide-19 R-Bovine Octapeptide-1 vary from person to person. The points below describe potential side effects that could occur, yet most users will not experience them when the ingredient is formulated and applied correctly.
- Mild redness or warmth at the application site
- Temporary itching or tingling
- Dry patches if combined with very high levels of alcohol or strong exfoliants
- Hives or swelling for individuals with a peptide allergy
- Watery eyes or irritation if an eye product migrates into the eye itself
If any of these effects appear stop using the product and seek advice from a medical professional.
Comedogenic Rating
Rating: 0/5. This fusion peptide is water soluble and contains no fatty acids, oils or waxes that could clog pores. Its molecular size is small enough to sit on the skin surface yet not large and occlusive like some plant butters. In finished formulas it is typically used at low concentrations alongside lightweight humectants, further reducing any pore blocking risk. Therefore it is considered safe for acne prone or breakout prone skin. The only caveat is that a product’s overall comedogenic potential depends on every ingredient in the formula, not just the peptide itself.
Summary
Tripeptide-49 Oligopeptide-91 Dipeptide-19 R-Bovine Octapeptide-1 is a lab crafted 34-amino-acid peptide that conditions skin by binding moisture and supporting a smooth comfortable feel. Brands appreciate it because it is stable in water based products, pairs well with other actives and offers a gentle alternative to heavier emollients. While not yet a household name it is gaining traction in mid to high end serums, eye gels and soothing masks thanks to its lightweight texture and vegan friendly production method. Safety data show a low irritation profile and no comedogenicity, making it suitable for most skin types. As with any new skincare ingredient it is wise to patch test when first trying a product containing this peptide to confirm personal tolerance.