What Is Tripeptide-49 Oligopeptide-91 Dipeptide-19 Sh-Polypeptide-1?
Tripeptide-49 Oligopeptide-91 Dipeptide-19 sh-Polypeptide-1 is a lab-designed fusion peptide made by linking the genetic blueprints for four smaller peptides into one long 314-amino-acid chain. Scientists build the gene on a computer, insert it into a strain of E. coli, then let the bacteria ferment in large tanks. After the cells produce the peptide, it is filtered, purified and dried into a fine powder ready for cosmetic labs.
The ingredient grew out of biotech advances that let formulators create tailor-made peptides for skin care. By combining sequences known for soothing, firming and hydrating properties, researchers aimed to deliver several skin benefits with one molecule. Since arriving on the market it has been adopted by premium skin care brands looking for high-performance actives that are gentle enough for daily use.
You will most often spot Tripeptide-49 Oligopeptide-91 Dipeptide-19 sh-Polypeptide-1 in concentrated anti-aging serums, lightweight moisturizers, sheet masks, eye creams and post-treatment recovery products where it can help calm skin and support a smoother appearance.
Tripeptide-49 Oligopeptide-91 Dipeptide-19 Sh-Polypeptide-1’s Cosmetic Benefits/Uses
This multi-talented peptide is prized for its ability to condition and nurture the skin surface.
As a skin-conditioning ingredient it helps draw moisture into the upper layers of the skin, supports a supple texture and promotes a more even, refreshed look. Regular use can leave the complexion feeling softer and appearing firmer thanks to the peptide’s ability to reinforce the skin barrier and encourage a healthy moisture balance.
Who Can Use Tripeptide-49 Oligopeptide-91 Dipeptide-19 Sh-Polypeptide-1
This peptide is considered gentle enough for virtually all skin types including dry, oily, combination and sensitive skin. Because it is lightweight and non occlusive it rarely clogs pores so acne-prone users can usually apply it without worry. Only those with a known allergy to peptides or to fermentation-derived ingredients may need to steer clear, though such reactions are uncommon.
The ingredient is produced through bacterial fermentation with no animal-derived substances, making it suitable for both vegetarians and vegans.
No studies have shown specific risks for pregnant or breastfeeding women when this peptide is used topically in standard cosmetic concentrations. Absorption through intact skin is minimal, yet out of caution this is not medical advice and anyone who is pregnant or nursing should run any skincare product past a qualified doctor first.
Tripeptide-49 Oligopeptide-91 Dipeptide-19 sh-Polypeptide-1 does not increase photosensitivity, so it can be used morning or night. Normal daytime sunscreen habits should still be followed to protect skin health.
Potential Side Effects/Adverse Reactions
Side effects from topical use of Tripeptide-49 Oligopeptide-91 Dipeptide-19 sh-Polypeptide-1 vary between individuals. The points below outline potential reactions, but most users experience none of these when the ingredient is formulated and applied correctly.
- Mild temporary redness or warmth at the application site
- Light itching or tingling in very sensitive skin
- Rare allergic contact dermatitis presenting as persistent redness, swelling or rash
- Occasional breakout flare-up if the overall formula is overly rich for oily skin
If any adverse reaction develops stop using the product and seek guidance from a healthcare professional.
Comedogenic Rating
Rating: 0 / 5
Tripeptide-49 Oligopeptide-91 Dipeptide-19 sh-Polypeptide-1 is a large water-soluble peptide with no oils, waxes or fatty acids that could block pores, so it earns a solid zero on the comedogenic scale. Its molecular size keeps it on the skin’s surface rather than sinking into sebaceous follicles where breakouts begin. This makes it suitable for acne-prone and congested skin types.
As with any ingredient, overall pore-clogging potential depends on the complete formula. If a serum or cream also contains heavy emollients, those additives, not the peptide itself, would be the likely culprits behind any congestion.
Summary
Tripeptide-49 Oligopeptide-91 Dipeptide-19 sh-Polypeptide-1 is a lab-crafted fusion peptide that conditions skin by attracting moisture, supporting the barrier and sending cell-friendly signals that encourage a smoother firmer look. Its hydrating soothing nature helps soften fine lines, calm irritation and leave the complexion more resilient.
Although effective it is still a niche active found mainly in premium serums, eye creams and recovery masks rather than in mass-market lotions. Brands that invest in biotech actives prize it for delivering multiple benefits while remaining gentle.
Topically applied at normal cosmetic levels it is considered low risk, with allergy or irritation reported only rarely. That said everyone’s skin is unique so it is smart to patch test any new product that features this peptide before adding it to your full routine.