Acetamide Mea: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
Share:
Inside this article:

All information on this page is verified using publicly available nomenclature standards and reference materials from The Personal Care Products Council (PCPC) and the European Commission's CosIng database. Our analyses are based on technical data from these sources to ensure accuracy and reliability.

What Is Acetamide Mea?

Acetamide Mea, also written as N-2-hydroxyethylacetamide, is a water-loving compound made by combining acetic acid with monoethanolamine. The result is a clear, nearly odorless liquid that mixes easily with water and alcohol. Chemists first explored it in the 1950s as a softening agent for textiles, and its ability to hold moisture soon caught the attention of cosmetic formulators. Today manufacturers create Acetamide Mea in controlled reactors where acetic anhydride reacts with monoethanolamine, then the mixture is purified and filtered to remove any leftovers from the reaction. Because it is gentle, stable and versatile, the ingredient shows up in a wide range of products such as shampoos, conditioners, leave-in sprays, curl creams, facial moisturizers, sheet masks, cleansing gels and lightweight serums.

Acetamide Mea’s Cosmetic Benefits/Uses

Formulators rely on Acetamide Mea for several handy roles that improve a product’s feel, performance and shelf life.

  • Hair conditioning: It coats the hair shaft to smooth rough cuticles, making strands look shinier and feel softer while reducing static
  • Humectant: The molecule attracts water from the air and locks it next to skin or hair, delivering lasting hydration without a greasy finish
  • Skin conditioning: By increasing water content in the outer layer of skin it leaves the surface supple, plump and comfortable
  • Cleansing: Its mild surfactant action helps lift away dirt and oil so formulas can clean without stripping natural moisture
  • Foam boosting: It stabilizes bubbles created by primary cleansers, giving shampoos and face washes a richer lather that rinses easily
  • Viscosity controlling: It fine-tunes thickness so products pour, pump or spread just the way consumers expect, preventing separation during storage

Who Can Use Acetamide Mea

Acetamide Mea suits most skin types including dry, normal, combination and oily because it delivers lightweight moisture without clogging pores or leaving residue. People with very reactive or allergy-prone skin should still read labels carefully since any ingredient can cause an individual sensitivity.

The compound is produced synthetically from acetic acid and monoethanolamine, not from animal sources, so it is considered suitable for vegans and vegetarians.

Current safety data indicate no specific risks for women who are pregnant or breastfeeding when Acetamide Mea is used at normal cosmetic levels, yet this is not medical advice. Expectant or nursing mothers should discuss any skincare product with a qualified healthcare professional to be sure it fits their personal situation.

Acetamide Mea does not make skin more sensitive to sunlight and can be used alongside daytime sunscreen without extra precautions. The ingredient is also odorless which makes it a good option for those avoiding added fragrance.

Potential Side Effects/Adverse Reactions

Responses to topical Acetamide Mea vary by individual. The effects listed below are possible yet unlikely for most users when the ingredient is included in a properly formulated product.

  • Transient stinging or tingling especially on freshly exfoliated or broken skin
  • Mild redness or irritation in those with sensitive or compromised skin barriers
  • Contact dermatitis in rare cases where a true allergy to the molecule develops
  • Eye discomfort such as watering or slight burning if the product accidentally gets into the eyes
  • Scalp irritation when left on the hair for extended periods in leave-in treatments

If any of these reactions occur stop using the product and seek advice from a medical professional.

Comedogenic Rating

Rating: 1/5. Acetamide Mea is highly water soluble and used at low levels, so it does not leave an oily film that could block pores. Laboratory data show it rinses cleanly and does not build up on skin. Because of this it earns a very low comedogenic score.

People prone to acne or breakouts can usually use products containing Acetamide Mea without extra concern.

The rating can edge higher if the formula also contains heavy oils or waxes that trap moisture against the skin, so assess the full ingredient list when judging any product.

Summary

Acetamide Mea works as a humectant, skin and hair conditioner, mild cleanser, foam booster and viscosity controller. It pulls water into the upper layers of skin or along the hair cuticle, then forms a light cushion of hydration that feels soft not greasy. Its amphiphilic nature lets it gently lift dirt and oils while stabilizing bubbles and balancing thickness so shampoos and lotions feel just right.

While not a household name, it is a behind the scenes staple, appearing in a range of shampoos, conditioners, facial gels and lightweight creams where long lasting moisture and a smooth texture are needed.

Safety reviews find it non toxic, non sensitizing at typical use levels and suitable for vegans. Still every person is unique so do a simple patch test when trying a new product that includes Acetamide Mea to confirm it agrees with your skin.

Was this article helpful?
More from Glooshi:
ADVERTISEMENT
Get all our top headlines in beauty.
Delivered right to your inbox each week. Zero spam, all goodness, opt-out at anytime.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Get the latest beauty news, top product recommendations & brand-exclusive discount codes direct to your inbox.
Send good feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Send bad feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Search