What Is Acetamino Methylsulfonylbutyroyl Dipeptide-57?
Acetamino Methylsulfonylbutyroyl Dipeptide-57 is a lab made short chain of two amino acids that has been linked to a small acetyl group and a sulfur rich methylsulfonyl fragment. Together these parts give the molecule a friendly attitude toward both water and skin lipids, so it can blend well in creams and serums. The peptide itself is inspired by natural skin proteins that help keep the surface smooth and supple.
This ingredient first drew attention in the early 2000s when researchers explored ways to pair well known soothing agents like methylsulfonylmethane (MSM) with modern signal peptides. By attaching the sulfur group to a tiny peptide they found a stable compound that could moisturize while supporting the skin’s own barrier. It has been used in cosmetic labs ever since, mostly in products that focus on comfort and hydration rather than heavy anti age claims.
Production starts with two pure amino acids that are coupled using standard peptide synthesis. An acetyl cap is added to protect the chain then the methylsulfonylbutyroyl group is linked to one end. After purification the powder is dried and shipped to formulators who dissolve it in water or a light glycol before blending it into finished products.
You will usually spot Acetamino Methylsulfonylbutyroyl Dipeptide-57 in moisturizers, calming masks, light lotions, leave-on facial toners and occasionally in aftershave balms or hand creams where extra softness is desired.
Acetamino Methylsulfonylbutyroyl Dipeptide-57’s Cosmetic Benefits/Uses
In skin care formulas this peptide serves two key purposes
- Emollient – it fills in tiny gaps on the skin surface so the texture feels smoother and silkier right after application. This soft touch can make a product feel more luxurious and helps reduce flaky or rough spots
- Humectant – it attracts and binds water from the environment and the deeper layers of the skin. This added moisture helps plump the surface, keeps dryness at bay and can improve the look of fine lines that show up more when skin lacks water
Who Can Use Acetamino Methylsulfonylbutyroyl Dipeptide-57
This peptide is gentle enough for nearly every skin type. Dry and mature skin often benefit the most because its humectant nature pulls in water while the emollient side leaves a soft feel. Sensitive skin usually tolerates it well thanks to the small size of the molecule and the lack of added fragrance or alcohol in most formulas. Oily or acne prone users can also apply it since it is lightweight and carries almost no risk of clogging pores.
Because the compound is produced entirely through laboratory synthesis using plant derived amino acids and sulfur donors, it is suitable for both vegans and vegetarians. No animal material is involved at any stage of manufacture or purification.
Current safety data show no link between topical use of this peptide and reproductive concerns. Pregnant or breastfeeding individuals can generally use products that contain it, yet this is not medical advice and it is best to discuss any new skin regimen with a qualified healthcare provider.
The molecule does not make skin more sensitive to sunlight so it will not increase the likelihood of sunburn. It also plays well with most other skincare actives such as niacinamide, ceramides and gentle exfoliating acids, making it easy to slot into an existing routine.
Potential Side Effects/Adverse Reactions
Side effects from topical Acetamino Methylsulfonylbutyroyl Dipeptide-57 vary from person to person. The points below describe potential reactions that could occur, although they are uncommon when the ingredient is used correctly in a well formulated product.
- Transient redness or warmth at the application site
- Mild stinging or tingling during the first few minutes after application
- Localized itching linked to sensitivity to one of the other ingredients in the formula
- Rare allergic contact dermatitis presenting as a rash or swelling
- Breakouts in extremely acne prone skin if combined with heavy occlusive bases
If any of these reactions occur stop using the product and seek advice from a healthcare professional.
Comedogenic Rating
Rating: 0 / 5
Acetamino Methylsulfonylbutyroyl Dipeptide-57 is water soluble, lightweight and used at very low concentrations. It leaves no greasy film and does not sit inside pores, so it earns the lowest possible score on the comedogenic scale.
Because of this it is considered suitable for skin that is prone to acne or breakouts.
As with any ingredient, the final product’s overall pore-clogging risk depends on the full formula. Heavy oils or waxes paired with this peptide can still trigger congestion even though the peptide itself is non-comedogenic.
Summary
Acetamino Methylsulfonylbutyroyl Dipeptide-57 works as an emollient and humectant. It smooths rough patches by filling tiny surface gaps then pulls water into the upper layers so skin stays hydrated and feels supple.
The peptide is not a blockbuster name yet it appears in a steady stream of modern moisturizers, masks and toners that target comfort rather than dramatic anti age claims. Formulators like its stability and vegan origin, users appreciate the immediate softness it gives.
Current data show the ingredient is safe for topical use with very low rates of irritation or pore clogging. As always it is smart to patch test a new product on a small area first just to confirm personal tolerance.