What Is Acetyl Sh-Oligopeptide-26 Decapeptide-57 Sp Amide?
Acetyl Sh-Oligopeptide-26 Decapeptide-57 Sp Amide is a lab-made peptide complex created by linking two short chains of amino acids, Sh-Oligopeptide-26 Sp and Decapeptide-57 Amide, then capping them with an acetyl group to improve stability and skin compatibility. Because it is synthetic, it does not come from animal or plant sources, which helps keep formulas consistent from batch to batch.
Peptides first caught the eye of cosmetic chemists in the early 2000s for their ability to signal and support healthy-looking skin and hair. As research advanced, brands began combining different peptide fragments to fine-tune specific benefits. This particular blend was developed to condition hair fibers, leading to smoother strands and a healthier appearance.
Production starts with solid-phase peptide synthesis, where each amino acid is added one at a time on a resin. After the two peptide chains are built, they are joined, acetylated and then purified to remove residual solvents and salts. The finished ingredient is a white powder that dissolves easily in water-based formulas.
You will most often see Acetyl Sh-Oligopeptide-26 Decapeptide-57 Sp Amide in leave-in conditioners, rinse-off masks, scalp serums, anti-breakage treatments and premium shampoos aimed at boosting softness and shine.
Acetyl Sh-Oligopeptide-26 Decapeptide-57 Sp Amide’s Cosmetic Benefits/Uses
The main role of this peptide complex is hair conditioning. By attaching to the hair surface it helps fill in rough spots, reducing friction, frizz and flyaways. The result is hair that feels silkier, looks shinier and is easier to comb, which can cut down on mechanical damage over time.
Who Can Use Acetyl Sh-Oligopeptide-26 Decapeptide-57 Sp Amide
This peptide complex is considered gentle enough for all scalp and hair types, including oily, dry, combination and sensitive scalps, because it is non-sensitising and has a neutral pH when formulated correctly. People dealing with issues like dandruff or eczema are not automatically excluded, but they may want to monitor how their skin responds since any new topical could aggravate existing conditions.
The ingredient is 100 percent synthetic with no animal or animal-derived components, making it suitable for vegans and vegetarians. It is also typically processed without animal testing when sourced from suppliers that follow cruelty-free standards, so it aligns well with most ethical preferences.
There is no evidence that Acetyl Sh-Oligopeptide-26 Decapeptide-57 Sp Amide poses a specific risk to women who are pregnant or breastfeeding. Nonetheless this is not medical advice and anyone expecting or nursing should review the full ingredient list of any product with their doctor to be extra sure it fits their individual health needs.
The peptide does not increase photosensitivity, so it will not make skin or scalp more prone to sunburn. It is color safe, compatible with chemically treated hair and does not interfere with common styling products.
Potential Side Effects/Adverse Reactions
Responses to topical Acetyl Sh-Oligopeptide-26 Decapeptide-57 Sp Amide differ from person to person. The following is a list of potential but unlikely side effects assuming the product has been formulated and preserved properly.
- Mild scalp redness or warmth
- Temporary itching or tingling where applied
- Rare allergic contact dermatitis resulting in small bumps or patches
- Eye irritation if the formula drips into the eyes during application or rinsing
- Product buildup that leaves hair feeling heavy when used in excess or layered with multiple protein-rich treatments
If you experience any of these reactions stop using the product and consult a healthcare professional for guidance.
Comedogenic Rating
Rating: 0/5
Acetyl Sh-Oligopeptide-26 Decapeptide-57 Sp Amide is a water-soluble peptide complex with no oily or waxy components that could clog pores, so it is classed as non-comedogenic. Its molecular size and polarity prevent it from building up inside follicles, making it a safe choice for those prone to acne or breakouts.
Because the ingredient is usually delivered in lightweight leave-in sprays, serums or rinse-off masks, the chance of pore blockage is even lower compared with heavier creams or butters.
Summary
Acetyl Sh-Oligopeptide-26 Decapeptide-57 Sp Amide is a lab-crafted peptide that conditions hair by attaching to damaged cuticle areas, smoothing rough spots and reducing friction so strands feel softer and look shinier. It is fully synthetic, vegan friendly and generally well tolerated on all scalp and hair types.
While not yet a household name, the peptide is picking up traction in premium hair care lines that focus on science-backed actives instead of traditional silicones. Formulators appreciate its ability to deliver a silky finish without heaviness.
Safety data show a very low risk of irritation or sensitisation when used at typical levels, making it suitable for daily use in leave-in or rinse-off products. As with any new cosmetic, it is wise to do a small patch test the first time you try a formula containing this ingredient just to be sure your skin agrees with it.