What Is Acetyl Sh-Oligopeptide-30 Sp?
Acetyl Sh-Oligopeptide-30 Sp is a small chain of amino acids that has been chemically acetylated, a simple process that helps the peptide stay stable and work well on skin. The “sh” part of its name means “synthetic human,” so the sequence is designed to mimic peptides found naturally in our skin. This ingredient is made in a lab using controlled fermentation, where friendly bacteria produce the original peptide, which is then purified and acetylated.
Peptides first gained attention in skincare in the early 2000s for their cell-friendly size and ability to signal skin to look smoother and firmer. As labs refined peptide tech, acetylated versions like Acetyl Sh-Oligopeptide-30 Sp appeared, offering longer shelf life and better skin affinity. Today you can spot this peptide in lightweight serums, sheet masks, anti-aging creams, brightening essences, eye treatments and post-procedure soothers where a gentle boost of skin support is needed.
Acetyl Sh-Oligopeptide-30 Sp’s Cosmetic Benefits/Uses
This peptide plays two key roles in formulas, helping skin look and feel healthier.
- Skin Conditioning – helps skin feel softer and more supple by attracting water and supporting the surface barrier so skin stays hydrated and smooth
- Skin Protecting – forms a light, breathable shield that reduces moisture loss and defends against everyday stressors like pollution and dry air, leaving skin calmer and more resilient
Who Can Use Acetyl Sh-Oligopeptide-30 Sp
This lab made peptide is considered gentle enough for most skin types. Dry and mature complexions appreciate its water binding skills while oily and combination types benefit from the lightweight feel that does not clog pores. Sensitive skin usually tolerates it well thanks to its mild nature and lack of fragrance or alcohol. There are no known concerns for darker skin tones or skin with rosacea although, as always, tolerance can vary person to person.
The ingredient is produced through fermentation and synthetic modification with no animal derived materials so it is suitable for both vegans and vegetarians.
No data suggests a risk for pregnant or breastfeeding women when the peptide is used topically in typical cosmetic concentrations. That said this is not medical advice and anyone expecting or nursing should have their doctor review the full product routine before use just to be safe.
Acetyl Sh-Oligopeptide-30 Sp does not absorb UV light or make skin more reactive to the sun so it is not considered photosensitizing. It layers well with most common actives including vitamin C, niacinamide, AHAs and retinoids and has no known interactions with prescription topicals.
Potential Side Effects/Adverse Reactions
Side effects and reactions to the topical application of Acetyl Sh-Oligopeptide-30 Sp can vary from person to person. The points below cover potential issues that could occur, yet they are not expected to be the typical user experience. When the ingredient is formulated and preserved correctly most people will not notice any negative effects.
- Temporary redness
- Mild itching or tingling on first applications
- Localized irritation if applied to broken or highly compromised skin
- Allergic contact dermatitis in individuals sensitive to peptides or acetyl groups (rare)
- Isolated breakouts in very acne-prone skin if the finished product contains occlusive co-ingredients
If any of these reactions occur stop using the product and consult a healthcare professional or dermatologist for guidance.
Comedogenic Rating
Rating: 0/5 – Acetyl Sh-Oligopeptide-30 Sp is a tiny, water-soluble peptide that does not create an oily film or block pores. Because it is used at low percentages and readily rinses away with normal cleansing, the molecule itself has no clogging potential. It is therefore considered safe for acne-prone or breakout-prone skin. If a finished product containing this peptide triggers blemishes, it is far more likely due to richer emollients or waxes in the formula rather than the peptide.
Summary
Acetyl Sh-Oligopeptide-30 Sp conditions skin by binding water to the surface and supporting a stronger moisture barrier, which leaves skin feeling smooth and supple. It also offers light skin-protecting benefits by creating a breathable shield that limits moisture loss and keeps daily environmental stressors at bay.
The peptide is not the most famous name on ingredient lists but formulators value it for its stability, gentle profile and compatibility with popular actives, so it is showing up in more serums, masks and creams aimed at hydration and barrier care.
Overall safety is high with very low risk of irritation or comedogenicity. Still, everyone’s skin is unique so it is smart to perform a simple patch test when trying any new product that features Acetyl Sh-Oligopeptide-30 Sp.