What Is Acetyl Sh-Pentapeptide-14 Sp Amide?
Acetyl Sh-Pentapeptide-14 Sp Amide is a lab-crafted peptide that has been acetylated, a small chemical tweak that makes the molecule more stable and easier for skin to accept. It starts with sh-Pentapeptide-14 Sp Amide, a string of five amino acids that mimic fragments found naturally in skin. Scientists add an acetyl group to the peptide during a controlled reaction, helping it stay active longer once blended into a formula.
The ingredient first appeared in advanced skin care during the early 2010s, when peptide research took off as brands looked for gentler options to support healthy skin. Today it is produced in specialized facilities where biochemists synthesize the base peptide through solid-phase peptide synthesis, purify it, then carry out the acetylation step before drying it into a fine powder.
You will most often see Acetyl Sh-Pentapeptide-14 Sp Amide in leave-on products that aim to hydrate and defend the skin such as lightweight serums, anti-aging creams, sheet masks and overnight moisturizers. It is usually added at low percentages alongside familiar hydrators like glycerin or hyaluronic acid.
Acetyl Sh-Pentapeptide-14 Sp Amide’s Cosmetic Benefits/Uses
This peptide offers two main benefits when blended into skin care formulas:
- Humectant – It attracts water to the skin surface helping to keep the outer layer plump and soft. This added moisture can reduce the look of fine lines and give skin a fresh glow
- Skin protecting – By reinforcing the skin’s own barrier proteins it helps guard against everyday stressors like pollution and dry air, which can lead to irritation or early signs of aging
Who Can Use Acetyl Sh-Pentapeptide-14 Sp Amide
This peptide suits most skin types including dry, normal, combination, oily and even sensitive complexions because it is lightweight and focused on hydration rather than exfoliation or deep resurfacing. Exceptionally reactive skin may still prefer formulas with minimal additives, but the peptide itself is considered gentle.
It is produced entirely in the lab without any animal-derived inputs so it is suitable for vegans and vegetarians.
Current data show no specific risks for women who are pregnant or breastfeeding when the ingredient is used topically at the low levels common in cosmetics. That said this is not medical advice and anyone who is expecting or nursing should review all skin care products with a qualified health professional to be safe.
The peptide does not absorb UV light and it does not trigger photosensitivity. Daily sunscreen is still important for overall skin health but no extra sun precautions are needed because of this ingredient.
Acetyl Sh-Pentapeptide-14 Sp Amide plays well with most other ingredients so it can be layered alongside staples like vitamin C, niacinamide and ceramides without concern.
Potential Side Effects/Adverse Reactions
Reactions to topical Acetyl Sh-Pentapeptide-14 Sp Amide differ from person to person. The issues listed below are only potential outcomes and are unlikely for the average user when the product has been correctly formulated.
- Mild redness or warmth shortly after application
- Temporary itching or stinging on very sensitive skin
- Rare allergic contact dermatitis marked by persistent rash or swelling
- Increased irritation when layered with high strength acids or retinoids
- Product pilling or uneven texture if paired with heavy silicone primers
If you experience any of the above stop using the product and consult a dermatologist or healthcare provider.
Comedogenic Rating
Rating: 0 / 5. Acetyl Sh-Pentapeptide-14 Sp Amide is a small, water-soluble peptide that does not form an oily film on the skin so it is not known to clog pores. It lacks heavy oils, waxes or large molecules that commonly trap sebum and dead cells. This makes it a safe pick for those prone to acne or breakouts. Because it is usually included at low concentrations in lightweight serums or gels, the risk of pore blockage remains very low even when layered with other products. If a formula causes congestion it is far more likely due to other ingredients such as rich emollients or fragrances rather than the peptide itself.
Summary
Acetyl Sh-Pentapeptide-14 Sp Amide acts primarily as a humectant and skin-protecting agent. It draws moisture toward the outer layer, helping skin stay plump and smooth, while also supporting the natural barrier proteins that shield against daily stress like pollution and dry air. These effects come from its short chain of amino acids that mimic elements already found in skin, and the added acetyl group keeps the peptide stable so it can keep working after it is applied.
The ingredient sits in the niche peptide category, so it is not as famous as hyaluronic acid or niacinamide, but it is gaining attention among brands that focus on gentle hydration and barrier care. Safety data so far show a very low risk profile with only rare reports of irritation. As with any new skincare product it is wise to do a small patch test first to be sure your skin agrees with the full formula.