What Is Acetyl Sh-Pentapeptide-35?
Acetyl Sh-Pentapeptide-35 is a lab crafted peptide created by reacting sh-Pentapeptide-35 with acetic acid, which adds stability and improves its ability to blend into skincare formulas. Peptides are short chains of amino acids and this particular pentapeptide contains five. By adding an acetyl group, chemists give the molecule better skin affinity, allowing it to do its job without breaking down too quickly once applied.
Peptide technology rose to popularity in the early 2000s when brands began using small, bio-mimicking chains to signal skin to behave more youthfully. Acetyl Sh-Pentapeptide-35 emerged during this wave as manufacturers sought targeted molecules that could condition skin without irritation. It is produced through controlled fermentation or solid-phase synthesis of the base pentapeptide, followed by an acetylation step that takes place in a sterile reactor. After purification, the finished ingredient is dried into a powder ready for cosmetic use.
You will typically find Acetyl Sh-Pentapeptide-35 in leave-on products where prolonged contact boosts its performance: anti-aging serums, lightweight moisturizers, sheet masks, eye creams and concentrated ampoules. Brands favor it in water-based formulas because it dissolves easily, making it suitable for both oil-free and richer emulsions.
Acetyl Sh-Pentapeptide-35’s Cosmetic Benefits/Uses
Acetyl Sh-Pentapeptide-35 mainly serves one key purpose in skincare products, yet that role can translate into multiple visible perks for the user.
Skin conditioning: As a skin-conditioning agent this peptide helps skin feel softer, smoother and more hydrated. By supporting the skin’s natural barrier it can reduce tightness and improve overall texture, which is why it often appears in formulas aimed at firming and revitalizing dull or mature complexions.
Who Can Use Acetyl Sh-Pentapeptide-35
This ingredient is well tolerated by most skin types including normal, dry, oily and combination since it is water soluble and lightweight. Sensitive skin often handles it better than some stronger actives because the peptide is designed to condition rather than exfoliate or stimulate. There is no evidence that it exacerbates acne so blemish-prone users can generally use it without concern.
Acetyl Sh-Pentapeptide-35 is made through laboratory synthesis with no animal-derived components, making it suitable for vegans and vegetarians.
No research suggests the peptide poses a specific risk during pregnancy or while breastfeeding. Nonetheless this is not medical advice; anyone who is pregnant or nursing should check with a qualified healthcare professional before adding new skincare products.
The ingredient does not make skin more sensitive to sunlight so it is classified as non-photosensitizing. Daily sunscreen is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to topical Acetyl Sh-Pentapeptide-35 differ from person to person. The effects listed below are only potential outcomes and most users experience none of them when the ingredient is included at customary cosmetic levels.
- Mild redness or warmth: Temporary flushing can occur, particularly on very reactive skin
- Itching or tingling: Some users report a brief pins-and-needles sensation after application
- Localized irritation: Dry patches or a stinging feeling may show up if the product is layered with strong acids or retinoids
- Allergic contact dermatitis: Rare but possible in individuals with a specific sensitivity to peptides or preservatives in the formula
If any discomfort, rash or swelling appears discontinue use and seek advice from a healthcare professional.
Comedogenic Rating
Rating: 0 / 5
Acetyl Sh-Pentapeptide-35 is a small, water-soluble peptide with no oily or waxy components so it does not clog pores or leave residue that could trap dead skin cells. It quickly absorbs into the upper layers of skin and is typically used at low concentrations, further reducing any pore-blocking risk. Because of these qualities the ingredient is considered suitable for people who are prone to acne or breakouts.
No data suggest that this peptide influences sebum production or bacterial growth, both of which can worsen congestion. Comedogenicity also depends on the full formula, so pairing the peptide with heavy butters or certain silicones may still lead to problems for very reactive users.
Summary
Acetyl Sh-Pentapeptide-35 is a lab-engineered pentapeptide that conditions skin by signaling it to maintain a healthy barrier, draw in moisture and feel smoother to the touch. Its acetyl group boosts stability and allows the molecule to meld seamlessly into water-based serums, creams and masks. While not the most famous peptide on the market, it has carved out a quiet niche among formulators who want a gentle, vegan friendly option for softening and revitalizing skin without irritation.
Current safety data show low risk of adverse reactions, with most users experiencing no side effects at normal cosmetic levels. As with any new skincare ingredient it is wise to perform a simple patch test before full-face use, especially if you have a history of sensitivities.