What Is Acetyl Sh-Tetrapeptide-1?
Acetyl Sh-Tetrapeptide-1 is a lab crafted peptide created by attaching a small acetyl group to Sh-Tetrapeptide-1, a chain of four amino acids. This acetyl step helps the peptide stay stable and better interact with skin. The raw materials are produced through controlled fermentation or solid phase synthesis, then purified, acetylated and blended into a water-based solution that cosmetic chemists can easily add to formulas.
The peptide first caught the beauty industry’s eye in the early 2000s when researchers were exploring gentler options to support the skin barrier. Because short peptides can signal skin cells to behave in a healthier way, brands began adding Acetyl Sh-Tetrapeptide-1 to products aimed at boosting comfort and resilience. You will most often see it in lightweight serums, calming moisturizers, after-sun gels, sheet masks, eye treatments and anti-aging lotions where a soothing touch is desired.
Acetyl Sh-Tetrapeptide-1’s Cosmetic Benefits/Uses
This ingredient serves one main purpose in skin care formulas.
Skin conditioning: Acetyl Sh-Tetrapeptide-1 helps the skin feel softer smoother and more supple. By supporting the natural barrier it can reduce the look of redness and dryness making the complexion appear calm and well hydrated.
Who Can Use Acetyl Sh-Tetrapeptide-1
Thanks to its gentle nature this peptide is generally suitable for all skin types including sensitive oily dry combination and mature skin. It supports the skin barrier without clogging pores or leaving a heavy feel so even acne prone users tend to tolerate it well. There are no known skin types that must avoid it unless an individual has a specific allergy to the ingredient.
Acetyl Sh-Tetrapeptide-1 is created in a laboratory from fermented or synthetically produced amino acids so no animal derived materials are involved. That makes it appropriate for both vegetarians and vegans.
Current data shows no evidence that topical use poses a risk during pregnancy or while breastfeeding. However this is not medical advice and anyone who is pregnant or nursing should consult a healthcare professional before adding new skincare products to their routine.
The peptide does not increase photosensitivity therefore it can be used morning or night. Standard daytime sun protection is still advised for overall skin health.
Potential Side Effects/Adverse Reactions
Side effects and reactions to the topical application of Acetyl Sh-Tetrapeptide-1 can vary from person to person. The list below covers potential issues yet these outcomes are uncommon when the ingredient is properly formulated.
- Mild redness or warmth shortly after application
- Temporary stinging or tingling on very sensitive skin
- Itchiness or dryness if layered with overly strong actives
- Rare allergic contact dermatitis in individuals sensitive to peptides or preservatives in the final product
If any uncomfortable reaction occurs discontinue use and seek guidance from a healthcare professional.
Comedogenic Rating
Rating: 0/5. Acetyl Sh-Tetrapeptide-1 is a tiny water-soluble molecule that does not contain oils or waxes, so it cannot physically block pores on its own. Available studies and formulators’ reports show no link between this peptide and increased breakouts. It is therefore suitable for acne-prone or congestion-prone skin. As always the finished product’s overall recipe matters; if the peptide is blended into a rich oily base the other ingredients―not the peptide itself―could contribute to clogged pores.
Summary
Acetyl Sh-Tetrapeptide-1 is a lab designed four-amino-acid peptide capped with an acetyl group that keeps it stable and efficient. Its main role is skin conditioning: it signals skin cells to strengthen the moisture barrier which helps the surface stay soft, calm and better hydrated. The ingredient quietly appears in serums, moisturizers, after-sun gels and eye creams but it is still a niche choice rather than a blockbuster star.
Current data ranks it as a low-risk, non-comedogenic addition to skincare with only rare reports of irritation or allergy. While most users enjoy smooth sailing, it is wise to patch test any new product containing Acetyl Sh-Tetrapeptide-1 to confirm personal compatibility.