What Is Acetyl Sh-Tripeptide-4 Amide?
Acetyl Sh-Tripeptide-4 Amide is a lab made peptide, a very short chain of three amino acids that has been capped at one end with an acetyl group and converted to an amide at the other. These small tweaks help protect the peptide from breaking down too quickly once it is mixed into creams or serums. The original tripeptide was first studied for its ability to signal skin cells to behave more like they did in younger skin. When researchers noticed its stability problems they developed this acetylated amide version and it soon appeared in commercial skin care around the early 2010s.
The material is produced by solid-phase peptide synthesis, the standard method for building precise amino acid chains. Each amino acid is added step by step on a resin bead, then the finished peptide is released, acetylated, converted to an amide and purified. Because the process is controlled from start to finish the final ingredient is highly consistent and free from animal by-products.
You will most often see Acetyl Sh-Tripeptide-4 Amide in anti-aging serums, firming moisturizers, sheet masks and targeted eye or neck treatments. Brands like it because it works well at low concentrations, mixes smoothly with water based formulas and pairs nicely with hydrators, antioxidants and mild exfoliants.
Acetyl Sh-Tripeptide-4 Amide’s Cosmetic Benefits/Uses
In skin care formulas Acetyl Sh-Tripeptide-4 Amide acts as a skin conditioning ingredient. By supporting the skin’s natural repair signals it can help the surface feel smoother, look firmer and maintain better hydration. Over time consistent use may soften the appearance of fine lines and give the complexion a healthier bounce.
Who Can Use Acetyl Sh-Tripeptide-4 Amide
This peptide suits most skin types including normal, dry, combination and oily because it is lightweight, water soluble and non greasy. Sensitive skin generally tolerates it well since it has no exfoliating acids or fragrances of its own, though people with a history of peptide allergies should be cautious.
The ingredient is created entirely through synthetic chemistry with no animal sourced starting materials so it is considered suitable for both vegetarians and vegans.
Current data shows no specific risks for women who are pregnant or breastfeeding when Acetyl Sh-Tripeptide-4 Amide is applied topically at the low levels found in cosmetics. This is not medical advice and anyone who is expecting or nursing should discuss any skincare product with a qualified healthcare professional before use just to be safe.
Acetyl Sh-Tripeptide-4 Amide does not make skin more sensitive to sunlight so it is not classed as a photosensitizer. Normal daytime sun protection habits are still recommended.
The peptide pairs well with common actives like niacinamide, hyaluronic acid, vitamin C and gentle retinoids which means it can slot into most routines without conflict.
Potential Side Effects/Adverse Reactions
Side effects and reactions to the topical application of Acetyl Sh-Tripeptide-4 Amide can vary from person to person. The list below covers potential issues but most users will not experience them when using well formulated products at recommended levels.
- Mild redness or warmth shortly after application
- Transient stinging on very compromised or freshly exfoliated skin
- Localized itching or tightness in individuals with highly reactive skin
- Rare allergic contact dermatitis presenting as persistent rash or swelling
- Eye irritation if the product accidentally gets into the eyes
If any uncomfortable reaction occurs discontinue use immediately and seek advice from a healthcare professional if symptoms do not improve.
Comedogenic Rating
Rating: 0/5. Acetyl Sh-Tripeptide-4 Amide is a tiny, water-soluble peptide that leaves no oily or occlusive residue on the skin. It does not clog pores or encourage excess sebum, so it earns the lowest possible score on the comedogenic scale. This makes it a comfortable choice for people who are prone to acne or breakouts.
The ingredient is typically used at very low levels, is easily rinsed away during cleansing and is compatible with lightweight, non-greasy formula bases. No data suggest it feeds acne-causing bacteria or interferes with normal pore function.
Summary
Acetyl Sh-Tripeptide-4 Amide is mainly a skin conditioning agent that helps skin look smoother, feel firmer and stay better hydrated by supporting the skin’s natural repair signals. Its small size allows it to work at low doses without heaviness, which is why brands often slip it into anti-aging serums, eye creams and sheet masks.
The peptide is moderately popular in modern skin care, sitting behind headline actives like retinol and niacinamide but showing up more each year as formulators seek gentle firming ingredients that pair well with other actives.
Current research and usage reports point to a very good safety profile with minimal irritation risk at cosmetic levels, yet every skin is unique. Whenever you try a new product that contains Acetyl Sh-Tripeptide-4 Amide it is wise to perform a small patch test first to confirm your personal tolerance.