What Is Acetyl Tetrapeptide-107 Amide?
Acetyl Tetrapeptide-107 Amide is a lab crafted peptide made by taking a chain of four amino acids, known as Tetrapeptide-107, and adding an acetyl group at one end while converting the other end into an amide. This small chemical tweak helps protect the peptide from breaking down too quickly on the skin and improves its ability to blend into cosmetic formulas. The ingredient does not come from plants or animals; it is produced through controlled fermentation or solid-phase peptide synthesis in a pharmaceutical-style facility, followed by purification and acetylation steps to meet cosmetic grade standards.
Peptides started gaining attention in skin care in the early 2000s when researchers discovered that short chains of amino acids could signal skin cells to behave in a more youthful way. Since then brands have been racing to develop new variations with better stability and targeted benefits. Acetyl Tetrapeptide-107 Amide is one of these newer generation peptides, valued for its supportive role in maintaining skin smoothness and comfort.
You will typically find this ingredient in leave-on products where prolonged contact maximizes its effect. Common formats include lightweight serums, hydrating lotions, anti-aging creams, eye treatments and sheet masks. It is often paired with humectants like glycerin or hyaluronic acid and antioxidants to create a well rounded formula that addresses dryness and early signs of aging.
Acetyl Tetrapeptide-107 Amide’s Cosmetic Benefits/Uses
In topical products Acetyl Tetrapeptide-107 Amide is prized for one main function.
Skin conditioning: The peptide helps keep the skin feeling soft, supple and comfortably hydrated. By reinforcing the skin’s natural barrier it can reduce the look of rough patches and improve overall texture, which is why formulators include it in products aimed at smoothing and revitalizing dull or tired complexions.
Who Can Use Acetyl Tetrapeptide-107 Amide
Because it is a lightweight, non greasy peptide, Acetyl Tetrapeptide-107 Amide suits nearly every skin type including dry, normal, combination, oily and sensitive. It does not clog pores so even acne prone skin can usually tolerate it without extra breakouts. No specific skin type needs to avoid it unless a personal allergy to peptides has been confirmed.
The ingredient is made in a lab with no animal derived raw materials or animal testing requirements, making it acceptable for both vegetarians and vegans.
Current research shows no direct risks for women who are pregnant or breastfeeding when this peptide is used as intended in topical products. Still, safety data in these groups is limited, so this information is not medical advice and anyone who is expecting or nursing should check with a qualified healthcare provider before introducing new skincare.
Acetyl Tetrapeptide-107 Amide does not increase photosensitivity. Daily sunscreen is always wise for overall skin health, but there is no special need to avoid sun exposure because of this ingredient.
The peptide plays well with common actives like niacinamide, hyaluronic acid, vitamin C and gentle exfoliating acids, so it can slot easily into most routines without special timing rules.
Potential Side Effects/Adverse Reactions
Side effects from topical Acetyl Tetrapeptide-107 Amide vary from person to person. The points below outline potential reactions yet most users experience none of them when using a well formulated product.
- Temporary redness or warmth at the application site
- Itching or mild stinging, especially on very sensitive skin
- Small bumps or hives that signal an allergic response
- Rare contact dermatitis marked by dryness, flaking or swelling
- Pimples if the overall formula is too heavy for an oily complexion
If any of these effects appear and do not settle quickly one should stop use and seek advice from a pharmacist or healthcare professional.
Comedogenic Rating
Rating: 0 (non-comedogenic)
Acetyl Tetrapeptide-107 Amide is a small water-soluble peptide that does not contain heavy oils, waxes or fatty acids that typically block pores. Its molecular structure is too large to settle inside follicles, so it is not expected to trigger comedone formation even in oily or acne-prone skin. This makes it a safe pick for people who struggle with breakouts.
The only caveat is that the final product formula matters. If the peptide sits in a rich cream loaded with occlusive butters the overall product could still feel heavy, but that would be due to the base ingredients, not the peptide itself.
Summary
Acetyl Tetrapeptide-107 Amide is a lab made four-amino-acid peptide that conditions skin by supporting a healthy moisture barrier and smoothing rough texture. The acetyl end group and amide tail help protect the peptide from breaking down, allowing it to stay active on the skin surface and deliver its softening effect.
While not a headline act like retinol or vitamin C, the ingredient is quietly gaining traction in modern serums and creams focused on comfort and barrier care. Brands appreciate that it is vegan friendly, gentle and easy to pair with other actives.
Current data shows a very low risk of irritation or pore clogging, so most users can apply it without worry. As with any new skincare ingredient it is wise to do a quick patch test first to rule out individual sensitivity and enjoy its benefits with confidence.