Acetyl Tyrosinamide: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
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All information on this page is verified using The Personal Care Products Council's (PCPC) INCI database. Our ingredient analyses are based exclusively on PCPC's technical data to ensure accuracy and reliability.

What Is Acetyl Tyrosinamide?

Acetyl Tyrosinamide, sometimes written as N-Acetyl L-Tyrosinamide, is a lab-modified form of the naturally occurring amino acid tyrosine. By attaching an acetyl group to tyrosine scientists create a more stable and water-friendly molecule that sits comfortably in modern skin care formulas. The ingredient did not appear in cosmetics until the early 2000s when research on amino-acid-based moisturizers gained pace. Manufacturers produce it through a simple two-step reaction: first tyrosine is dissolved in a controlled solution then an acetylating agent is added, bonding the acetyl group to the amino acid. After purification and drying the resulting white powder is ready for use.

Because of its gentle nature and compatibility with other ingredients, Acetyl Tyrosinamide shows up in a variety of products. You will most often find it in daily moisturizers, hydrating serums, sheet masks, soothing after-sun lotions and premium anti-aging creams where it supports the skin’s natural softness.

Acetyl Tyrosinamide’s Cosmetic Benefits/Uses

This ingredient is valued for a single core role in formulas

Skin conditioning: Acetyl Tyrosinamide helps maintain a smooth, supple surface by attracting and holding water in the outer layer of skin. Its amino-acid backbone mimics elements already present in the skin’s natural moisturizing factors so it works in harmony with the complexion, boosting comfort and leaving a soft finish without heaviness.

Who Can Use Acetyl Tyrosinamide

Thanks to its gentle, water-binding nature Acetyl Tyrosinamide suits nearly every skin type. Dry skin benefits from the added moisture, oily or combination complexions appreciate its light non-greasy feel, and sensitive skin tolerates it well because it lacks common irritants. At present there is no evidence that it aggravates acne, rosacea or other reactive conditions.

The ingredient is typically synthesized from plant-derived or lab-grown tyrosine with no animal by-products, making it acceptable for both vegans and vegetarians. Always check the full product label in case other components do not share the same status.

Current safety data indicate no specific risks for pregnant or breastfeeding women when Acetyl Tyrosinamide is used at the low concentrations found in cosmetics. This is not medical advice and anyone who is pregnant or nursing should review all skincare choices with a qualified healthcare provider to be certain the product fits their individual circumstances.

Acetyl Tyrosinamide does not increase sensitivity to sunlight so daily use does not require special photo-protection beyond a regular broad-spectrum sunscreen. It also plays well with common actives such as niacinamide, glycerin and peptides, making it a flexible addition to most routines.

Potential Side Effects/Adverse Reactions

Reactions to topical Acetyl Tyrosinamide can vary from person to person. The points below outline potential side effects, yet they remain rare when the ingredient is formulated and used as intended.

  • Transient redness or warmth: a brief flush may appear on very sensitive skin directly after application
  • Mild stinging or tingling: usually subsides quickly as the product settles
  • Allergic contact dermatitis: an uncommon outcome involving persistent itching, rash or swelling that signals an individual allergy to the compound or another component in the formula
  • Formulation incompatibility: high amounts of strong acids or alcohols in the same product could heighten irritation potential for those with compromised skin barriers

If any of these effects occur stop using the product and seek guidance from a healthcare professional or dermatologist.

Comedogenic Rating

Rating: 0 out of 5

Acetyl Tyrosinamide is highly water soluble, used in very low amounts and has no oily or waxy residues that might block pores. Studies and anecdotal reports show no link between this molecule and the formation of comedones, which is why it earns the lowest possible score.

Because of this non-comedogenic profile the ingredient is considered safe for people who are prone to acne or frequent breakouts.

Products that feature Acetyl Tyrosinamide usually combine it with other lightweight humectants such as glycerin or hyaluronic acid, further reducing any pore-clogging risk.

Summary

Acetyl Tyrosinamide works as a skin-conditioning humectant that draws water into the outer skin layers and helps keep it there. Its amino acid backbone mirrors part of the skin’s own natural moisturizing factors so it blends seamlessly with the complexion to leave a soft smooth finish.

While not as famous as hyaluronic acid or niacinamide, this ingredient is quietly gaining traction in moisturizers, hydrating serums and soothing masks aimed at people who want lightweight yet effective hydration.

Current safety data show it to be low risk, non-sensitizing and vegan friendly. That said everyone’s skin is different so it is still wise to patch test any new product that contains Acetyl Tyrosinamide before applying it to larger areas.

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