Adamantanyl Trihydroxybenzamide: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
Share:
Inside this article:

All information on this page is verified using The Personal Care Products Council's (PCPC) INCI database. Our ingredient analyses are based exclusively on PCPC's technical data to ensure accuracy and reliability.

What Is Adamantanyl Trihydroxybenzamide?

Adamantanyl Trihydroxybenzamide is a lab-created molecule that combines an adamantane backbone, valued for its stability, with a trihydroxybenzamide group known for its ability to interact with free radicals. Chemists first explored the compound in the early 2000s while searching for new antioxidants that could tolerate heat and light better than naturally sourced options. After safety testing it began appearing in skin care formulas within the last decade.

The ingredient is synthesized through a multi-step process that bonds an adamantane derivative to a trihydroxybenzoic acid, followed by amidation. This controlled manufacturing method produces a high-purity powder that dissolves easily in cosmetic emulsions.

You will most often find Adamantanyl Trihydroxybenzamide in serums, anti-aging creams, brightening spot treatments, sheet masks and daily moisturizers aimed at protecting skin from environmental stress.

Adamantanyl Trihydroxybenzamide’s Cosmetic Benefits/Uses

In topical products Adamantanyl Trihydroxybenzamide offers several helpful actions

  • Antioxidant: Scavenges free radicals generated by UV light and pollution which helps slow the look of premature aging and keeps formulas from oxidizing in the bottle
  • Bleaching: Gradually reduces the appearance of dark spots and uneven tone by interrupting excess melanin production giving skin a brighter more uniform look
  • Skin Protecting: Forms a light shield on the surface that supports the skin barrier and lessens irritation from external aggressors

Who Can Use Adamantanyl Trihydroxybenzamide

Most skin types can enjoy this ingredient. Its lightweight feel suits oily and combination skin while its barrier support is welcome on dry and mature skin. Sensitive skin usually tolerates it because it is non-acidic and free of common irritants, though anyone with a history of fragrance or preservative allergies should read full product labels in case other additives cause trouble.

Adamantanyl Trihydroxybenzamide is produced entirely in the lab from mineral and petrochemical feedstocks so it contains no animal-derived components. That makes it suitable for vegans and vegetarians when used in formulas that also avoid animal testing.

Current data shows no known issues for women who are pregnant or breastfeeding when the ingredient is used on intact skin. Absorption through the skin appears minimal and no hormonal activity has been reported. Still this is not medical advice and anyone expecting or nursing should ask a doctor before adding new products just to be safe.

The molecule itself does not make skin more sensitive to sunlight and can be used day or night. Because it helps defend against free radicals it actually pairs well with sunscreen for daytime protection. There are no other major lifestyle restrictions linked to its use.

Potential Side Effects/Adverse Reactions

Side effects from topical Adamantanyl Trihydroxybenzamide can vary from person to person. The points below list potential reactions yet they are uncommon when the ingredient is formulated and used correctly.

  • Mild redness or warmth shortly after application
  • Temporary dryness or tightness if layered with strong exfoliating acids
  • Light stinging in very sensitive or broken skin
  • Allergic contact dermatitis in people sensitive to the molecule or other formula components
  • Uneven light patches if overused on darker skin tones due to its gradual bleaching effect

If any of these reactions appear stop using the product and seek advice from a healthcare professional.

Comedogenic Rating

Rating: 1/5

Adamantanyl Trihydroxybenzamide is a lightweight crystalline powder that dissolves fully without leaving an oily residue so it has little tendency to block pores. It is not derived from heavy plant oils or waxes and its molecular size is small enough to rinse cleanly, which keeps the risk of comedone formation low.

This low score means it is generally suitable for people prone to acne or frequent breakouts. Still the overall formula matters; if the ingredient sits in a rich butter or silicone heavy base the product as a whole could be more pore clogging.

Summary

Adamantanyl Trihydroxybenzamide works as an antioxidant, a gentle bleaching agent and a skin protector. It donates electrons to neutralize free radicals, interrupts extra melanin production to fade dark spots over time and forms a light surface film that supports the barrier against pollutants and irritants.

The ingredient is gaining traction but is still considered a specialty addition found mostly in mid to high end serums and moisturizers rather than mainstream drugstore lines. As testing continues and formulators look for stable lab made antioxidants its presence is expected to grow.

Current research shows a strong safety profile with low irritation potential and minimal skin absorption, making it a low risk choice for most users. Even so skin can react unpredictably so it is wise to patch test any new product that lists Adamantanyl Trihydroxybenzamide before applying it to your whole face.

Was this article helpful?
More from Glooshi:
ADVERTISEMENT
Get all our top headlines in beauty.
Delivered right to your inbox each week. Zero spam, all goodness, opt-out at anytime.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Get the latest beauty news, top product recommendations & brand-exclusive discount codes direct to your inbox.
Send good feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Send bad feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Search