Aminobenzoyl Tripeptide-39 Hydroxamic Acid: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Aminobenzoyl Tripeptide-39 Hydroxamic Acid?

Aminobenzoyl Tripeptide-39 Hydroxamic Acid is a lab-crafted ingredient made by combining a short chain of three amino acids, known as Tripeptide-39, with aminobenzoic acid and hydroxamic acid. The result is a small, stable molecule that can blend well into modern skin care formulas. Peptides have been popular in cosmetics since the early 2000s for their skin-friendly profile, and chemists soon began pairing them with other compounds to improve performance. This particular pairing, finalized within the last decade, was designed to give the peptide extra staying power on the skin and to help protect it from everyday stress factors like pollution and surface dehydration.

The production process starts with the synthetic creation of Tripeptide-39 in a controlled environment. The peptide is then reacted with aminobenzoic acid, which offers a protective element, and hydroxamic acid, known for its ability to bind metal ions and keep formulas stable. The finished ingredient is purified and tested for safety before it makes its way into cosmetic labs.

You will usually spot Aminobenzoyl Tripeptide-39 Hydroxamic Acid in leave-on products where long-lasting skin protection is desired, such as lightweight daily moisturizers, anti-aging serums, smoothing primers and overnight masks. It can also appear in targeted eye treatments and pollution defense creams, where formulators want a gentle yet effective shield for delicate areas.

Aminobenzoyl Tripeptide-39 Hydroxamic Acid’s Cosmetic Benefits/Uses

This ingredient is valued for one primary role in skin care products.

As a skin protecting agent, Aminobenzoyl Tripeptide-39 Hydroxamic Acid forms a breathable layer on the surface that helps defend against environmental stressors like dust, smoke and free radicals. By reinforcing the skin’s natural barrier it supports better moisture retention, keeps the complexion looking smooth and can reduce the appearance of dullness caused by day-to-day exposure.

Who Can Use Aminobenzoyl Tripeptide-39 Hydroxamic Acid

This peptide blend is generally friendly to most skin types including normal, dry, oily and combination. Its light, film-forming nature helps lock in moisture without adding grease so even acne-prone users tend to tolerate it well. Those with very sensitive or reactive skin should still approach new formulas carefully, as the added acids in the molecule could be a bit stimulating.

The ingredient is made entirely in a lab without any animal-derived components, making it suitable for both vegans and vegetarians.

Current safety data shows no specific risks for women who are pregnant or breastfeeding when the ingredient is used topically in standard cosmetic concentrations. That said this is not medical advice and anyone who is expecting or nursing should run their full routine past a healthcare professional to be safe.

Aminobenzoyl Tripeptide-39 Hydroxamic Acid is not known to cause photosensitivity so it can be used day or night. Regular sunscreen use is still important for overall skin health.

Potential Side Effects/Adverse Reactions

Responses to topical Aminobenzoyl Tripeptide-39 Hydroxamic Acid differ from person to person. The points below list potential effects that are unlikely for most users when the ingredient is formulated and used correctly.

  • Mild redness or warmth shortly after application
  • Temporary stinging on very dry or freshly exfoliated skin
  • Rare cases of contact dermatitis for individuals allergic to peptide or acid components
  • Increased dryness if layered with strong exfoliating acids or high-strength retinoids

If you notice persistent irritation stop using the product and consult a healthcare professional.

Comedogenic Rating

Rating: 1 out of 5

Aminobenzoyl Tripeptide-39 Hydroxamic Acid is water based and designed to sit as an ultra-thin breathable film rather than a heavy layer of oil, so it is very unlikely to block pores. Its peptide core and acid attachments are low in lipid content, which keeps the rating near the bottom of the scale.

This makes the ingredient generally suitable for people who break out easily.

Formula context matters: if the finished product adds rich butters or waxes the overall comedogenic feel may rise even though the peptide itself stays low.

Summary

Aminobenzoyl Tripeptide-39 Hydroxamic Acid is mainly used as a skin protecting agent. It forms a light film that helps shield skin from pollution, surface dehydration and everyday aggressors, supporting a smoother healthier looking barrier.

The ingredient is still a niche pick compared to legacy peptides, though it is gaining quiet interest among formulators who want fresh protective tech without adding heaviness.

Current research and real-world use show it to be safe for most skin types with low risk of irritation or clogging. As with any new skin care addition it is smart to patch test a product first to ensure personal comfort.

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