What Is Aminolevulinoyl Sh-Pentapeptide-19?
Aminolevulinoyl Sh-Pentapeptide-19 is a lab-designed molecule created by linking aminolevulinic acid, a naturally occurring amino acid derivative, to a five-unit peptide sequence. The result is a small, water-loving compound that blends the skin-friendly traits of a peptide with the free-radical fighting power of aminolevulinic acid.
The idea of joining these two parts came from research into light-activated skin treatments in the early 2000s. Scientists noticed that aminolevulinic acid could protect cells from oxidative stress, while short peptides were already popular for supporting skin repair. By combining them, chemists produced a single ingredient that offered both benefits without the need for light activation, making it suitable for everyday cosmetics.
Manufacturing starts with fermenting plant-sourced sugars to obtain aminolevulinic acid. In a separate step, the five-amino-acid peptide is synthesized through solid-phase peptide chemistry. The two are then joined in a controlled reaction, purified, and spray-dried into a fine powder ready for formulation.
Brands add Aminolevulinoyl Sh-Pentapeptide-19 to serums, anti-aging creams, sheet masks, lightweight moisturizers, scalp tonics, and leave-in hair treatments where it can target early signs of skin fatigue and support stronger, shinier hair.
Aminolevulinoyl Sh-Pentapeptide-19’s Cosmetic Benefits/Uses
Below are the main ways this multitasker can improve a beauty formula
- Antioxidant – helps neutralize free radicals generated by UV exposure and pollution which can otherwise lead to dullness and early wrinkles
- Hair conditioning – forms a thin film along the hair shaft that boosts smoothness and light reflection so strands look softer and healthier
- Skin protecting – supports the skin barrier by reinforcing surface proteins and reducing the impact of daily stressors such as temperature changes or harsh cleansers
Who Can Use Aminolevulinoyl Sh-Pentapeptide-19
This peptide suits most skin types, including oily, dry, combination and mature skin, thanks to its lightweight water-soluble nature. Sensitive skin usually tolerates it well although anyone prone to peptide allergies or struggling with a compromised barrier should introduce it slowly to avoid possible irritation.
The compound is synthesized in a lab without animal-derived materials so it is considered suitable for vegans and vegetarians.
There is no evidence that topical Aminolevulinoyl Sh-Pentapeptide-19 poses specific risks for pregnant or breastfeeding women, yet safety data are limited. This content is not medical advice and expectant or nursing mothers should bring any new skincare product to their doctor’s attention before use to be safe.
The molecule is not known to trigger photosensitivity and can be worn during the day under sunscreen. It also plays well with common actives such as niacinamide, hyaluronic acid and most plant oils, making it easy to slot into an existing routine.
Potential Side Effects/Adverse Reactions
Responses to topical Aminolevulinoyl Sh-Pentapeptide-19 differ from person to person. The effects listed below are only potential issues and, when the ingredient has been formulated correctly, most users will not encounter them.
- Transient redness or warmth – a brief flush that generally settles within minutes of application
- Mild itching or tingling – usually linked to very dry or compromised skin barriers
- Allergic contact dermatitis – rare but possible in individuals with a known peptide sensitivity
- Eye irritation – stinging or watering if the product accidentally gets into the eyes
- Interaction with highly acidic formulas – extreme pH levels can degrade the peptide and increase the likelihood of irritation
If you experience any persistent or severe reaction stop using the product immediately and consult a healthcare professional.
Comedogenic Rating
Rating: 0 out of 5
Aminolevulinoyl Sh-Pentapeptide-19 is a small, water-soluble peptide with no greasy carriers or pore-clogging oils. It sits on the skin surface, delivers its antioxidant action then rinses or absorbs away without leaving residue that could block follicles. For this reason it earns a solid zero on the comedogenic scale.
Because it is non-comedogenic the ingredient is generally considered suitable for people prone to acne or frequent breakouts.
Formulators typically include it at low percentages, further lowering any risk of buildup that might otherwise contribute to congestion.
Summary
Aminolevulinoyl Sh-Pentapeptide-19 works as an antioxidant that neutralizes everyday environmental stress, a skin protector that reinforces surface proteins and a hair conditioner that smooths cuticles for added shine. It accomplishes these tasks by combining the free-radical scavenging power of aminolevulinic acid with the barrier-supporting qualities of a five-unit peptide.
You will not find it on every beauty shelf yet. The molecule is still a niche active mainly used by innovation-focused brands looking to offer lightweight peptide benefits without the cost of longer chains.
Safety data so far show a low irritation profile, no comedogenicity and compatibility with most common actives. As with any new cosmetic ingredient it is wise to patch test first to be sure your skin tolerates the formula.