Aminopropyl Calcium/Magnesium Polysilsesquioxane Chloride: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
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All information on this page is verified using The Personal Care Products Council's (PCPC) INCI database. Our ingredient analyses are based exclusively on PCPC's technical data to ensure accuracy and reliability.

What Is Aminopropyl Calcium/Magnesium Polysilsesquioxane Chloride?

Aminopropyl Calcium/Magnesium Polysilsesquioxane Chloride is a silicone-based ingredient created from 3-aminopropyltriethoxysilane that has been hydrolyzed and condensed, then reacted with calcium chloride and magnesium chloride. The result is a network of silica units linked to calcium and magnesium ions, forming a lightweight film-forming material that attracts water. Although silicones have been part of skin care since the 1950s, this specific compound is newer and was developed to deliver the familiar smooth feel of silicones while adding moisture-binding minerals. Manufacturing involves controlled water-driven reactions that link the silane molecules, followed by purification and spray drying to create a stable powder that disperses easily in water-based or water-in-oil formulas.

Formulators add Aminopropyl Calcium/Magnesium Polysilsesquioxane Chloride to leave-on skincare such as moisturizers, anti-aging serums, sheet masks and soothing lotions. Its film-forming and water-holding traits also make it useful in primers and hydrating face mists where a light silky finish is desired.

Aminopropyl Calcium/Magnesium Polysilsesquioxane Chloride’s Cosmetic Benefits/Uses

This ingredient supports skin hydration and overall feel through two main roles:

  • Humectant: It pulls moisture from the air and from deeper skin layers toward the surface, helping skin stay plump and comfortable throughout the day.
  • Skin conditioning: By forming a soft breathable film, it smooths rough patches, reduces the appearance of fine lines and leaves a silky touch without heaviness or grease.

Who Can Use Aminopropyl Calcium/Magnesium Polysilsesquioxane Chloride

This ingredient is considered gentle and is generally suited to all skin types including dry, normal, combination and oily skin. Its lightweight film and humectant action can be especially helpful for dehydrated skin, while the non greasy finish means it will not weigh down oilier complexions. Sensitive skin usually tolerates it well because silicones and mineral salts tend to be inert, though individuals with a history of silicone sensitivity should approach with caution.

Aminopropyl Calcium/Magnesium Polysilsesquioxane Chloride is synthetic and contains no animal derived material so it is compatible with vegan and vegetarian lifestyles.

No data suggest that the ingredient poses a specific risk to women who are pregnant or breastfeeding. Current cosmetic safety assessments rate it as safe for general use in rinse off and leave on products. That said this is not medical advice and anyone who is pregnant or nursing should show the full ingredient list of any product to a healthcare provider before use to be extra sure it aligns with personal circumstances.

The compound is not known to cause photosensitivity so it will not make skin more prone to sunburn. Regular daytime sunscreen is still advised for overall skin health. The ingredient is also fragrance free and does not interact with common actives such as retinoids or vitamin C, allowing it to slot easily into most routines.

Potential Side Effects/Adverse Reactions

Responses to topical Aminopropyl Calcium/Magnesium Polysilsesquioxane Chloride differ from person to person. The effects listed below are only potential outcomes and are unlikely for most users when the ingredient is formulated and used correctly.

  • Mild stinging or burning a brief tingling sensation can occur on very compromised or freshly exfoliated skin
  • Redness or irritation rare and typically linked to individual sensitivity to silicones or amines
  • Contact dermatitis an allergic reaction presenting as itchiness rash or swelling though reported cases are scarce
  • Eye irritation if the product accidentally migrates into the eyes it may cause watering or discomfort
  • Clogged pores heavy layering with occlusive products on top could theoretically trap debris leading to comedones in acne prone users

If any persistent irritation or other adverse reaction is noticed discontinue use immediately and consult a healthcare professional.

Comedogenic Rating

Rating: 1 (very low likelihood of clogging pores)

Aminopropyl Calcium/Magnesium Polysilsesquioxane Chloride is a lightweight silicone-based polymer that forms a breathable film rather than an occlusive seal. Its large molecular structure sits on the surface and is too big to collect inside pores, which keeps the risk of blackheads and whiteheads minimal. Mineral ions of calcium and magnesium further reduce stickiness so the ingredient does not trap excess oil or debris. For most people, including those prone to acne or breakouts, this compound should pose little concern in well-balanced formulations. Only when layered under very heavy creams could it potentially contribute to congestion.

Summary

Aminopropyl Calcium/Magnesium Polysilsesquioxane Chloride works as a humectant and skin-conditioning agent by drawing water to the skin and laying down a silky, flexible film that smooths texture and softens the look of fine lines. Its hybrid structure combines classic silicone slip with moisture-binding calcium and magnesium, giving products a pleasant feel without greasiness.

While not as famous as dimethicone or glycerin, this ingredient is quietly gaining traction in modern moisturizers, serums and primers because formulators appreciate its feather-light finish and mineral boost.

Current safety reviews show it to be non-sensitizing, non-phototoxic and appropriate for all skin types when used as directed. As with any new skincare product, a short patch test is wise to confirm personal tolerance before full-face application.

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