Aminopropyl Magnesium Polysilsesquioxane Chloride: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
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All information on this page is verified using The Personal Care Products Council's (PCPC) INCI database. Our ingredient analyses are based exclusively on PCPC's technical data to ensure accuracy and reliability.

What Is Aminopropyl Magnesium Polysilsesquioxane Chloride?

Aminopropyl Magnesium Polysilsesquioxane Chloride is a silicone based resin that carries an aminopropyl group and a touch of magnesium chloride. In simple terms it is a network of silicon and oxygen atoms arranged in cage like structures that hold onto water and help keep unwanted microbes in check. The ingredient was first explored in the early 2000s when formulators searched for lighter feeling silicones that could also offer skin care benefits. By reacting 3-aminopropyltriethoxysilane with water, chemists trigger hydrolysis and condensation that build the three-dimensional polysilsesquioxane framework. Adding magnesium chloride during the process stabilizes the structure and gives it extra antimicrobial power.

You will most often see Aminopropyl Magnesium Polysilsesquioxane Chloride in leave-on products that aim to hydrate and smooth the skin. Common examples include lightweight moisturizers, gel creams, anti-aging serums, sheet masks, acne friendly lotions and after-shave balms. It is prized for delivering a silky touch without the heavy or greasy feel some traditional silicones can leave behind.

Aminopropyl Magnesium Polysilsesquioxane Chloride’s Cosmetic Benefits/Uses

This multitasking ingredient supports formulas in several ways

  • Antimicrobial – helps curb the growth of odor-causing or spoilage microbes, which can extend product shelf life and keep skin feeling fresh
  • Humectant – attracts and binds water to the skin surface, boosting hydration and helping maintain a soft supple feel throughout the day
  • Skin Conditioning – forms a breathable film that smooths rough patches, adds slip and enhances the overall sensory experience of a cream or serum

Who Can Use Aminopropyl Magnesium Polysilsesquioxane Chloride

Thanks to its lightweight silicone backbone and water binding ability this ingredient suits most skin types, including oily, combination and normal. Dry or dehydrated skin can also benefit from the extra humectant support without feeling greasy. Sensitive skin generally tolerates it well because it is non reactive and sits on the surface rather than penetrating deeply. There are no known reasons for extremely oily or compromised barrier skin to avoid it although, as with any new ingredient, user experience can vary.

Because Aminopropyl Magnesium Polysilsesquioxane Chloride is produced entirely from synthetic sources and contains no animal derived matter it is suitable for both vegans and vegetarians. No animal testing is required for its manufacture under most current cosmetic regulations.

Available safety data do not indicate any reproductive or developmental concerns so products containing this ingredient are considered safe for use during pregnancy and while breastfeeding. This is not medical advice and pregnant or nursing individuals should still review all skincare choices with their healthcare provider.

The molecule is not known to cause photosensitivity so it will not make skin more prone to sunburn. Standard daytime sun protection is still recommended for overall skin health.

Potential Side Effects/Adverse Reactions

Responses to topical Aminopropyl Magnesium Polysilsesquioxane Chloride can differ from person to person. The effects listed below are potential possibilities and are unlikely to occur for most users when the ingredient is properly formulated.

  • Mild skin irritation – a small number of users may notice temporary redness or itching, usually due to individual sensitivity
  • Stinging on compromised skin – recently exfoliated or damaged skin might feel a brief sting when the resin touches open areas
  • Contact dermatitis – rare allergic reactions have been reported with aminopropyl siloxanes leading to rash or swelling
  • Eye irritation – if a product accidentally gets into the eyes it can cause watering or discomfort until rinsed out

If any persistent burning, rash or swelling develops discontinue use and consult a healthcare professional

Comedogenic Rating

Rating: 1/5

Aminopropyl Magnesium Polysilsesquioxane Chloride forms a breathable film and sits on the surface rather than sinking into pores. Its cage like silicone structure is large and inert so it does not mingle with sebum or harden inside follicles. A trace amount of magnesium chloride does not boost pore clogging potential. All of this places it near the bottom of the scale.

Suitable for acne-prone and breakout-prone skin.

As with any film former, very heavy layering with occlusive products might trap oils underneath, which could indirectly aggravate congestion in rare cases.

Summary

Aminopropyl Magnesium Polysilsesquioxane Chloride acts as an antimicrobial, humectant and skin conditioning agent. It binds water to keep skin hydrated, lays down a smooth silky veil that softens texture and discourages the growth of unwanted microbes, helping formulas stay fresh while reducing surface bacteria that can trigger odor.

It is not the most famous silicone derivative on the shelf but formulators who want a lighter feel with extra skin care perks are steadily adding it to gel creams, serums and after-shaves.

Available safety data show a low risk profile with only occasional mild irritation reported. Still, everyone’s skin is different so it is smart to perform a quick patch test before fully incorporating any new product containing this ingredient.

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