Ascorbyl Tetraisopalmitate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Ascorbyl Tetraisopalmitate?

Ascorbyl Tetraisopalmitate is a fat-soluble form of vitamin C created by joining L-ascorbic acid with four isopalmitic acid groups. This pairing lets the molecule dissolve in oils, making it more stable and easier for skin to accept than regular water-based vitamin C. First explored in the late 1980s as chemists looked for a gentler vitamin C for skin care, it gained traction when brands sought high-performance antioxidants that would not break down quickly. To make it, manufacturers blend purified ascorbic acid with isopalmitic acid under controlled heat and vacuum, then refine the product into an oil-like liquid. You will spot it in serums, facial oils, anti-aging creams, brightening masks, sunscreens and lip treatments where lasting antioxidant power and a smooth skin feel are desired.

Ascorbyl Tetraisopalmitate’s Cosmetic Benefits/Uses

This ingredient offers two key functions that improve both the product and the skin experience.

  • Antioxidant: Helps neutralize free radicals caused by sun and pollution, which supports a brighter, more even skin tone and can soften the look of fine lines
  • Emollient: Adds a light, silky feel to formulas, helping them spread easily while reducing dryness and rough patches

Who Can Use Ascorbyl Tetraisopalmitate

This form of vitamin C is generally well tolerated by most skin types including dry, normal, combination and even many sensitive skins because its oil loving structure lowers the chance of the stinging sometimes linked to water based vitamin C powders. Very oily or acne prone skin may prefer lighter formulations as rich oils in the final product could feel heavy or clogging.

The ingredient itself is synthesized from vitamin C and plant derived isopalmitic acid so it is suitable for vegans and vegetarians when sourced from manufacturers that avoid animal by-products. As always, check the full ingredient list of the finished product for animal derived additives such as beeswax or lanolin to be certain.

Current research does not show any direct risk linked to topical use during pregnancy or while breastfeeding. That said this is not medical advice and anyone who is pregnant or nursing should review all skincare choices with a qualified healthcare provider first to stay on the safe side.

Ascorbyl Tetraisopalmitate does not increase photosensitivity. In fact it can help limit sun induced free radical damage though a broad spectrum sunscreen is still essential during daylight hours.

Potential Side Effects/Adverse Reactions

Responses to topical Ascorbyl Tetraisopalmitate differ from person to person. The points below outline possible but uncommon effects when the ingredient is used in a correctly formulated cosmetic product.

  • Mild redness or warmth shortly after application
  • Transient stinging on very sensitive or compromised skin
  • Breakouts if the surrounding formula is too rich for oily or acne prone complexions
  • Allergic reaction marked by itching swelling or rash in rare cases
  • Interaction with highly acidic exfoliants or benzoyl peroxide which could lower the ingredient’s stability and benefits

If any discomfort or visible irritation develops discontinue use and seek advice from a medical professional or dermatologist.

Comedogenic Rating

Rating: 2 out of 5. Although Ascorbyl Tetraisopalmitate is derived from isopalmitic acid, the esterified structure makes it less likely to clog pores than straight fatty acids. Most users do not report an increase in blackheads or whiteheads when the ingredient is used at typical skincare levels of 1-10 percent. However its oily nature means it still carries a small risk for congestion in individuals who are highly prone to breakouts, especially if the overall formula is rich in additional occlusive oils or waxes. In short this ingredient is usually fine for acne-prone skin but lightweight products are preferred.

Remember that the comedogenic potential of a finished product depends on the whole recipe, so the presence of heavy butters, silicones or waxes can raise the chance of clogged pores even if Ascorbyl Tetraisopalmitate itself is relatively low risk.

Summary

Ascorbyl Tetraisopalmitate acts as both an antioxidant and an emollient. Its fat-soluble form lets it slip through the skin’s lipid barrier where it neutralizes free radicals, supports a brighter more even tone and helps soften the look of fine lines. At the same time its silky texture adds slip and reduces dryness, improving the feel of creams, serums and oils.

While not as famous as classic L-ascorbic acid, interest in this derivative has grown steadily because it pairs vitamin C benefits with better stability and gentleness. You will often see it in mid- to high-end formulas aimed at brightening or anti-aging.

Overall safety is high with only occasional mild redness or stinging in very sensitive users. As with any new skincare ingredient a simple patch test is wise before full-face use just to be certain your skin agrees with it.

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