Bacillus/Mesembryanthemum Crystallinum Extract Ferment Lysate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
Share:
Inside this article:

All information on this page is verified using publicly available nomenclature standards and reference materials from The Personal Care Products Council (PCPC) and the European Commission's CosIng database. Our analyses are based on technical data from these sources to ensure accuracy and reliability.

What Is Bacillus/Mesembryanthemum Crystallinum Extract Ferment Lysate?

Bacillus/Mesembryanthemum Crystallinum Extract Ferment Lysate is a skin-loving ingredient obtained when an extract of Mesembryanthemum crystallinum, also known as the ice plant, is fermented with a strain of the friendly bacterium Bacillus. The ice plant is rich in minerals, amino acids and protective sugars that help it survive harsh, dry climates. During fermentation the Bacillus breaks down the plant material into smaller peptides, polysaccharides and micronutrients that can be more readily absorbed by skin. Once fermentation is complete the mixture is lysed, or gently broken apart, to release these beneficial fragments, then filtered into a clear liquid suitable for cosmetic use.

Fermentation technology has been used in skincare for decades because it can enhance the bioavailability of natural extracts. As consumer interest in gentle yet effective botanicals grew, formulators began exploring fermented ice plant for its hydrating and soothing properties, leading to its appearance in modern beauty products.

The lysate is made by harvesting pesticide-free ice plant, producing a water-based extract, inoculating it with Bacillus, allowing controlled fermentation, then heating or using enzymes to rupture the bacterial cells. The result is a stable, odor-neutral liquid that blends easily into water-based formulations.

You will typically find Bacillus/Mesembryanthemum Crystallinum Extract Ferment Lysate in moisturizers, hydrating serums, anti-aging creams, sheet masks, soothing after-sun gels and leave-on treatments that aim to boost softness and resilience.

Bacillus/Mesembryanthemum Crystallinum Extract Ferment Lysate’s Cosmetic Benefits/Uses

This ingredient is classed as a skin-conditioning agent, meaning it helps keep the skin looking and feeling its best. By delivering lightweight peptides, sugars and minerals it supports the skin’s natural moisture balance, leaves the surface feeling smoother and can enhance suppleness over time.

Who Can Use Bacillus/Mesembryanthemum Crystallinum Extract Ferment Lysate

This ferment lysate is gentle and water-light so it tends to suit all major skin types including dry, normal, combination and oily. Its soothing profile makes it a good option for sensitive or redness-prone skin as well. There are no known qualities that would make it unsuitable for acneic or mature skin.

The ingredient is derived from a plant extract and a food-grade bacterial ferment, with no animal-derived processing aids, which makes it appropriate for vegans and vegetarians.

Based on current safety data there is no specific warning against use during pregnancy or while breastfeeding. That said this information is educational only and anyone who is pregnant or nursing should check with a healthcare professional before introducing new skincare products.

The lysate does not contain photosensitising molecules so it is not known to increase sun sensitivity. It also plays well with most common skincare actives and preservatives used in leave-on formulas.

Potential Side Effects/Adverse Reactions

Individual responses to Bacillus/Mesembryanthemum Crystallinum Extract Ferment Lysate can vary. The points below outline potential but unlikely reactions when the ingredient is applied topically in a properly formulated product.

  • Mild stinging or warmth especially on very compromised or freshly exfoliated skin
  • Transient redness that usually subsides within minutes as the skin adjusts
  • Allergic contact dermatitis in the rare event a person is sensitive to plant peptides or fermentation by-products
  • Follicular irritation if used in a formula that also contains high levels of strong acids or alcohol

If irritation or any unexpected reaction occurs discontinue use and consult a healthcare professional

Comedogenic Rating

Rating: 1 (very low clogging potential)

Bacillus/Mesembryanthemum Crystallinum Extract Ferment Lysate is a water based ferment with no heavy oils or waxes, so it does not linger inside pores or create an occlusive film that can trap debris. Its peptides and sugars dissolve fully in water leaving minimal residue after absorption which keeps the chance of pore blockage extremely low.

Because of this the lysate is generally suitable for skin that is prone to acne or breakouts. Only in rare cases where a finished product pairs it with comedogenic emollients could issues arise.

As with any ingredient, the overall formula and an individual’s unique skin chemistry are the real deciding factors in whether breakouts occur.

Summary

Bacillus/Mesembryanthemum Crystallinum Extract Ferment Lysate is first and foremost a skin conditioning agent. Through fermentation it delivers small, easily absorbed peptides, minerals and natural sugars that help reinforce the skin barrier, boost hydration and leave the surface feeling smooth and resilient.

While not yet a household name, the lysate has been gaining quiet popularity among formulators who favor gentle fermented botanicals for clean beauty and sensitive skin lines.

Current data shows it to be safe for all skin types with a very low risk of irritation or pore clogging. Even so, everyone’s skin is different so it is wise to patch test any new product containing this ingredient before applying it more broadly.

Was this article helpful?
More from Glooshi:
ADVERTISEMENT
Get all our top headlines in beauty.
Delivered right to your inbox each week. Zero spam, all goodness, opt-out at anytime.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Get the latest beauty news, top product recommendations & brand-exclusive discount codes direct to your inbox.
Send good feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Send bad feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Search