What Is Barley Oligopeptide-160 Sh-Polypeptide-112?
Barley Oligopeptide-160 Sh-Polypeptide-112 is a plant-made fusion peptide created when scientists give barley the genetic instructions to produce two short human-inspired proteins, Oligopeptide-160 and Sh-Polypeptide-112, as a single 150-amino-acid chain. The barley plant weaves these amino acids together just like it does its own proteins, sometimes adding natural touches such as disulfide bonds or sugar groups. The result is a vegan, renewable source of a peptide that would be expensive to make by other means.
The idea of using barley as a mini factory comes from the early 2000s when researchers looked for gentle yet effective ways to make human-like peptides for cosmetics. Barley is safe, easy to grow and keeps production costs down while meeting clean beauty goals. After harvesting, the peptide is extracted from the grain, purified and dried into a fine powder that blends smoothly into water-based formulas.
Today you will most often see Barley Oligopeptide-160 Sh-Polypeptide-112 in leave-in hair serums, scalp tonics, anti-aging face creams, sheet masks, lightweight lotions and targeted eye or neck treatments where brands want a plant-derived peptide boost.
Barley Oligopeptide-160 Sh-Polypeptide-112’s Cosmetic Benefits/Uses
This multifunctional peptide adds value to both skin and hair products.
- Hair Conditioning: Helps smooth the hair shaft, reduces static and improves combability so strands feel softer and look shinier.
- Skin Conditioning: Supports a hydrated, supple feel, can make rough or tired skin appear smoother and may give formulas a light firming effect.
Who Can Use Barley Oligopeptide-160 Sh-Polypeptide-112
This peptide is gentle enough for most skin types including dry, oily, combination and sensitive skin. Because it is lightweight and non occlusive it suits acne prone skin as well, though people with a known grain or barley allergy should avoid it to prevent a possible reaction.
Since the peptide is grown inside barley and contains no animal sourced material it aligns with vegan and vegetarian values. Its plant origin also appeals to anyone looking for more sustainable cosmetic options.
No data suggests that topical use affects pregnancy or breastfeeding. Still, this is not medical advice and expectant or nursing women should discuss any new skincare product with their healthcare provider to be safe.
The ingredient does not increase photosensitivity so it can be used morning or night without raising the risk of sunburn. Regular daytime sun protection is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to Barley Oligopeptide-160 Sh-Polypeptide-112 vary from person to person. The effects listed below are possible but uncommon when the ingredient is formulated and used correctly.
- Mild redness or stinging in very sensitive skin
- Itching or hives in individuals allergic to barley or other grains
- Contact dermatitis if paired with aggressive actives such as strong acids or retinoids
- Eye irritation if the product accidentally gets into the eyes
If any irritation or unexpected reaction occurs discontinue use and consult a qualified healthcare professional.
Comedogenic Rating
Rating: 0
Barley Oligopeptide-160 Sh-Polypeptide-112 is a large, water-soluble peptide that does not create an oily film or linger inside pores, so it poses virtually no risk of clogging them. It is typically delivered in lightweight, water-based formulas rather than heavy oils or waxes that can trap debris.
Suitable for acne-prone and breakout-prone skin.
No added fragrances or fatty carriers are required for this peptide to work, which further lowers any comedogenic potential.
Summary
Barley Oligopeptide-160 Sh-Polypeptide-112 conditions skin and hair by forming a thin, breathable layer of amino acids that smooths texture, pulls in water and improves softness. On hair it helps reduce static and frizz while adding light shine. On skin it supports a plump, supple feel and can give a mild firming look.
While still a niche ingredient, its vegan barley origin and gentle performance are gaining attention in clean beauty lines and premium hair serums.
Overall safety is high with only rare issues linked to barley allergies or very sensitive skin. As with any new cosmetic, patch testing is wise before full use.