What Is Barley Sh-Polypeptide-17?
Barley Sh-Polypeptide-17 is a lab designed version of a natural human protein called Interleukin-1 Alpha, grown inside barley plants instead of animal or bacterial cells. Scientists insert a copy of the human gene into the barley genome or use a short-term expression method, then the plants act as tiny factories that build the single chain protein from the usual 20 amino acids. The finished molecule can include up to 272 amino acids along with helpful stabilizing features like disulfide bonds or light sugar groups. After harvesting, the protein is purified, filtered and dried into a fine cosmetic-grade powder.
This plant based approach surfaced in the early 2000s when brands started looking for sustainable, hypoallergenic sources of high-performance peptides. Barley offers a clean growth environment and avoids animal-derived material, making the ingredient appealing for modern beauty lines focused on safety and sustainability.
You will spot Barley Sh-Polypeptide-17 in lightweight serums, anti aging creams, sheet masks, soothing lotions, leave-in hair conditioners, restorative hair masks and scalp tonics where it is valued for both skin and hair care actions.
Barley Sh-Polypeptide-17’s Cosmetic Benefits/Uses
This bioengineered peptide brings a dual set of perks that improve the feel and look of skin and hair.
- Hair Conditioning: Forms a flexible film along the hair shaft that helps lock in moisture, smooths cuticles and reduces static so strands look shinier and feel softer
- Skin Conditioning: Supports the skin barrier by binding water to the surface, giving a plumper appearance and soothing dryness or tightness without a greasy finish
Who Can Use Barley Sh-Polypeptide-17
Most skin types tolerate this barley-grown peptide well. It is lightweight and water soluble, so oily and combination skin enjoy its non-greasy feel while dry or mature skin appreciate the extra moisture binding. Sensitive skin users usually do fine too because the molecule is purified and free of fragrance, though anyone with a known barley or grain allergy should proceed with caution.
The ingredient is produced in plants and contains no animal-derived material, making it suitable for vegetarians and vegans who prefer cruelty-free formulas.
No data suggest that Barley Sh-Polypeptide-17 poses a specific risk to pregnant or breastfeeding women when used in cosmetics. Still, this is not medical advice and anyone who is expecting or nursing should review new products with a qualified healthcare provider.
The peptide does not absorb UV light and is not known to trigger photosensitivity, so it can be used day or night without raising sunburn risk.
Potential Side Effects/Adverse Reactions
Responses to topical Barley Sh-Polypeptide-17 vary from person to person. The effects listed below are uncommon and most users will not experience them when the ingredient is formulated correctly.
- Mild skin irritation such as redness or tingling
- Allergic contact dermatitis in individuals sensitive to barley proteins
- Temporary itching or flaking on the scalp when used in hair products
- Eye stinging if the product accidentally gets into the eyes
If any of these reactions appear discontinue use and consult a healthcare professional.
Comedogenic Rating
Rating: 0 (non-comedogenic)
Barley Sh-Polypeptide-17 is a large, water-soluble peptide that sits on the surface of skin rather than sinking into pores or mixing with sebum. It contains no oils, waxes or fatty acids that commonly promote clogging, so it does not create the kind of environment where blackheads or pimples typically form.
Suitable for acne-prone or breakout-prone skin types.
Because the protein is usually incorporated at low percentages and rinses away easily, it poses virtually no risk of pore blockage even when layered with other products.
Summary
Barley Sh-Polypeptide-17 is a plant-derived copy of the human Interleukin-1 Alpha protein that conditions hair by forming a flexible moisture-locking film and conditions skin by binding water to the surface for a smoother, plumper feel. Its clean, water-soluble profile lets it deliver these benefits without heaviness.
While not as famous as hyaluronic acid or collagen peptides, this barley-grown protein is steadily popping up in niche serums, soothing creams and hair masks aimed at eco-conscious shoppers who want vegan biotech actives.
Current research and in-market use indicate it is very safe, showing low irritation potential and no comedogenicity, but as with any new cosmetic ingredient it is wise to perform a quick patch test when trying a fresh product to make sure your skin agrees with it.