Barley Sh-Polypeptide-25: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Barley Sh-Polypeptide-25?

Barley Sh-Polypeptide-25 is a lab designed chain of amino acids grown inside transgenic barley. Scientists insert a precise gene into the plant so the barley produces a human-identical peptide throughout its grains. After harvest the peptide is separated, filtered and spray dried, creating a pure powdered ingredient that is free from animal remnants and easy to blend into skin care formulas.

Interest in plant-based peptides rose as brands searched for gentler sustainable actives for aging and dehydrated skin. Early studies showed this barley peptide could leave skin feeling smoother and more elastic, so formulators began using it in premium moisturizers and anti-aging serums around the late 2010s. You will now find it in hydrating masks, eye creams, leave-on treatments and after-sun lotions aimed at boosting softness and comfort.

Barley Sh-Polypeptide-25’s Cosmetic Benefits/Uses

Its single official role in cosmetics is skin conditioning, a broad term that covers several helpful effects for the user.

As a skin conditioning agent Barley Sh-Polypeptide-25 attracts and holds moisture on the skin’s surface, giving an immediate feeling of softness and flexibility. By supporting the outer barrier it can smooth rough patches so creams spread more evenly and the skin feels less tight after washing. With consistent use this added hydration helps the complexion look fresher and healthier.

Who Can Use Barley Sh-Polypeptide-25

Because it is meant to boost hydration without leaving a greasy film Barley Sh-Polypeptide-25 suits most skin types, from dry and mature to combination and even oily skin that still needs lightweight moisture. Sensitive skin generally tolerates the peptide well since it does not rely on acids or strong resurfacing agents. There are no known reasons for very dry or very oily skin to avoid it, though individuals with a history of barley or grain allergies should be cautious and look for any warning from the brand about trace proteins.

The ingredient is produced entirely inside a plant so it contains no animal material, which makes it appropriate for both vegetarians and vegans. It also fits into many clean and sustainable formulations because the barley can be grown in controlled fields rather than sourced from animals or harsh chemical processes.

No research flags Barley Sh-Polypeptide-25 as unsafe for pregnant or breastfeeding women when used on the skin. Still this is not medical advice and anyone who is expecting or nursing should show the full product label to a qualified healthcare provider if they have questions.

The peptide does not increase sun sensitivity, so it can be used in morning or night routines without making skin more prone to burning. Standard daytime sunscreen habits still apply because healthy skin needs daily UV protection no matter which actives are being used.

Potential Side Effects/Adverse Reactions

Responses to any cosmetic ingredient vary from person to person. The effects listed below are possible but uncommon when Barley Sh-Polypeptide-25 is correctly formulated and applied.

  • Mild redness or warmth
  • Itching or stinging on sensitive skin
  • Localized swelling in people with barley or grain allergies
  • Contact dermatitis linked to other ingredients in the same formula rather than the peptide itself
  • Rare cross reaction in users with severe gluten intolerance, though the peptide is typically purified of gluten proteins

If any discomfort or visible irritation occurs stop using the product and consult a healthcare professional if symptoms persist or worsen.

Comedogenic Rating

Rating: 0 / 5

Barley Sh-Polypeptide-25 is a water-soluble peptide powder that contains no oils, waxes or heavy emollients that could clog pores. Once blended into a formula it dissolves completely and sits on the skin as a lightweight humectant layer rather than an occlusive film. For that reason it is considered non-comedogenic and is generally suitable for acne-prone or breakout-prone skin.

Because its molecular weight is high compared with typical pore-blocking agents it is unlikely to penetrate into follicles where comedones form. Most finished products also use the peptide at low percentages, further reducing any risk of congestion.

Summary

Barley Sh-Polypeptide-25 is a lab grown plant peptide that conditions skin by drawing in moisture, reinforcing the surface barrier and leaving a smoother feel. These benefits come from its humectant nature and ability to sit neatly on the outer layers where it supports hydration and suppleness.

Although not yet a household name the ingredient is gaining traction in premium moisturizers, eye creams and after-sun treatments as brands look for vegan sustainable actives that are gentle yet effective.

Current data shows the peptide is safe for topical use with low risk of irritation or pore clogging. As with any new skincare ingredient it is smart to perform a small patch test when trying a product that contains it especially for those with very sensitive or allergy-prone skin.

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