What Is Biotinoyl Tripeptide-35?
Biotinoyl Tripeptide-35 is a lab-crafted molecule that links biotin, a vitamin best known for supporting healthy hair and nails, with a short chain of three amino acids called a tripeptide. By fusing the vitamin to the peptide, chemists created a small, water-soluble ingredient that can travel easily through the surface layers of skin and hair. The idea first appeared in the early 2000s when researchers looked for new ways to deliver biotin topically without the heaviness of oils. Today it is produced through a controlled reaction: the tripeptide is synthesized by solid-phase peptide chemistry, purified, then coupled with activated biotin to form a stable bond. The finished ingredient is found in lightweight serums, scalp tonics, leave-on conditioners, lash and brow enhancers, anti-aging face masks, soothing moisturizers and targeted treatments designed to balance oily skin.
Biotinoyl Tripeptide-35’s Cosmetic Benefits/Uses
This multitasker brings several helpful actions to personal care formulas:
- Anti-Sebum – helps moderate excess oil on the scalp and face so hair looks fresher for longer and skin appears less shiny
- Antimicrobial – keeps microbial growth in check which supports a cleaner product and may calm blemish-prone areas
- Antioxidant – fights off environmental free radicals that can dull hair color and lead to early signs of skin aging
- Hair Conditioning – improves the feel and strength of strands making them softer and less prone to breakage while also supporting fuller-looking lashes and brows
Who Can Use Biotinoyl Tripeptide-35
Because it is water based and lightweight, Biotinoyl Tripeptide-35 works well for nearly all skin types including oily, combination, normal and dry. Sensitive skin can usually tolerate it too since it is non-fragrant and used at low concentrations, though people with a history of peptide allergies should stay alert for any irritation.
The ingredient is made synthetically from biotin and laboratory produced amino acids, so there are no animal-derived raw materials. This makes it a suitable choice for both vegans and vegetarians as long as the finished product also avoids animal testing.
No specific warnings are attached to topical use during pregnancy or breastfeeding, and the small size of the molecule means it is unlikely to penetrate deeply enough to enter the bloodstream. That said this is not medical advice and anyone who is pregnant or nursing should ask their doctor before starting a new cosmetic product just to be safe.
Biotinoyl Tripeptide-35 is not known to increase sun sensitivity. Daily sunscreen is still recommended for overall skin health but there is no extra photo-protective step required when using this peptide.
Potential Side Effects/Adverse Reactions
Reactions to topical Biotinoyl Tripeptide-35 differ from person to person. The points below list potential side effects yet these outcomes are uncommon when the ingredient is included correctly in a well-formulated product.
- Mild redness or tingling – usually short lived on sensitive or freshly exfoliated skin
- Dry patches – can appear if the formula contains strong astringents alongside the peptide
- Contact allergy – very rare but possible for individuals already allergic to biotin or certain peptides
- Eye irritation – may occur if a lash or brow serum is applied too close to the waterline
If any discomfort or unexpected reaction shows up stop using the product and seek guidance from a healthcare professional.
Comedogenic Rating
Rating: 0 / 5 (non-comedogenic)
Biotinoyl Tripeptide-35 is a small, water-soluble peptide-vitamin complex that does not leave an oily or waxy film on skin. It rinses cleanly, does not build up inside pores and shows no affinity for sebum, so it earns the lowest possible score on the comedogenic scale. This makes it a safe pick for people who struggle with clogged pores or breakouts.
Because it is usually added at low levels to lightweight serums, sprays or gels, the peptide itself is unlikely to cause acne. Any pore issues linked to a finished product are more likely tied to heavier emollients or silicones in the overall formula rather than to Biotinoyl Tripeptide-35.
Summary
Biotinoyl Tripeptide-35 combines biotin with a trio of amino acids to deliver four key perks: it tempers excess oil, keeps microbes in check, defends against free radicals and leaves hair fibers stronger and smoother. The molecule’s tiny size allows it to slip through the surface layer of skin or hair, where it can bind lightly to keratin and provide targeted support without weighing anything down.
While not as famous as collagen peptides or niacinamide, this ingredient has carved out a steady niche in lash serums, scalp tonics and lightweight moisturizers aimed at oily or combination skin. Its clean safety record, vegan origin and zero comedogenicity keep it in good standing with formulators and consumers alike.
Topical use is considered very safe with only rare reports of mild irritation yet everyone’s skin is different so it is smart to patch test a new product for a couple of days before slathering it on fully.