Bis-Gluconamidoethylaminopropyl Dimethicone: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
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All information on this page is verified using The Personal Care Products Council's (PCPC) INCI database. Our ingredient analyses are based exclusively on PCPC's technical data to ensure accuracy and reliability.

What Is Bis-Gluconamidoethylaminopropyl Dimethicone?

Bis-Gluconamidoethylaminopropyl Dimethicone is a specialty silicone created by bonding traditional dimethicone with sugar-derived gluconamide groups and small amounts of amino groups. The silicone backbone gives it the silky feel and spreadability associated with dimethicone while the sugar pieces help it cling to wet or damaged hair. Manufacturers produce it by first forming aminopropyl dimethicone, then reacting it with gluconic acid or its salts in a controlled process that attaches the gluconamide units along the chain.

Sugar-modified silicones like this one began to show up in hair care during the late 1990s when formulators looked for ways to deliver the smooth feel of dimethicone without the heavy buildup that earlier silicones sometimes caused. The added sugar groups improve water dispersibility, making the ingredient easier to wash out while still giving lasting conditioning.

Today Bis-Gluconamidoethylaminopropyl Dimethicone is most often used in rinse-out and leave-in conditioners, hair masks, color-protecting shampoos, smoothing serums, heat-protectant sprays and anti-frizz creams.

Bis-Gluconamidoethylaminopropyl Dimethicone’s Cosmetic Benefits/Uses

This ingredient is prized for one main job in personal care formulas.

Hair conditioning: It forms a lightweight, flexible film that smoothes the cuticle, adds shine and helps detangle, which in turn reduces breakage during brushing. The sugar-modified structure lets it condition without leaving a greasy feel, and it rinses more cleanly than older silicone oils. It also offers a bit of thermal protection, helping hair withstand heat styling tools.

Who Can Use Bis-Gluconamidoethylaminopropyl Dimethicone

This ingredient is gentle enough for all scalp and hair types including oily, dry, combination and sensitive. Because it is lightweight and rinses cleanly it rarely weighs down strands, though people with extremely fine or low-density hair might prefer a lower concentration to keep volume.

Bis-Gluconamidoethylaminopropyl Dimethicone is made from silicone, sugar and nitrogen-containing compounds produced in the lab, so it contains no animal derived materials. That makes it suitable for vegans and vegetarians as long as the finished product and the brand’s policies also align with cruelty-free standards.

Current safety data show no special risks for women who are pregnant or breastfeeding. The molecule is large, sits on the hair surface and is unlikely to enter the bloodstream. Still, this is not medical advice and anyone who is expecting or nursing should show any new hair or scalp product to a qualified health professional before using it.

The ingredient does not cause photosensitivity and can be used in daytime or nighttime routines without increasing the chance of sunburn. It is also color-safe and compatible with chemically treated or heat-styled hair.

Potential Side Effects/Adverse Reactions

Responses to topical Bis-Gluconamidoethylaminopropyl Dimethicone differ from person to person. The points below describe potential issues yet most users will not notice any problems when the ingredient is included at normal cosmetic levels.

  • Mild scalp or skin irritation such as itching or redness in very sensitive individuals
  • Allergic contact dermatitis in users already allergic to silicones or gluconate derivatives
  • Product buildup that leaves hair looking limp or dull if the formula is overused or not rinsed out properly
  • Possible interference with the penetration of certain leave-on actives because the ingredient forms a protective film

If any of these effects occur stop using the product and consult a healthcare professional or dermatologist.

Comedogenic Rating

Rating: 1 out of 5

Bis-Gluconamidoethylaminopropyl Dimethicone is a large, water-dispersible silicone that tends to sit on the hair shaft rather than penetrating skin follicles. Its size and partial water solubility mean it is unlikely to block pores, so it earns a very low score. Most formulas that include it are rinse-off or designed for hair ends, further reducing contact time with facial skin.

Because of its low pore-clogging potential it is generally suitable for people who are prone to acne or breakouts.

Only leave-on products applied directly to facial skin could pose a minor risk, and even then the chance of congestion is low compared with heavier straight silicones or greasy plant oils.

Summary

Bis-Gluconamidoethylaminopropyl Dimethicone is a sugar-modified silicone used mainly for hair conditioning. It forms a light, flexible film that smooths cuticles, boosts shine, aids detangling and offers mild heat protection while rinsing away more easily than traditional silicones, so hair feels conditioned without heavy buildup.

Although not a household name, it appears in a fair number of mid- to high-end conditioners, masks and serums where brands want silicone performance with a cleaner finish. Its popularity is steady rather than overwhelming, partly because it costs more than standard dimethicone.

Current safety data show a very low risk of irritation, sensitization or systemic absorption, making it safe for daily cosmetic use. As with any new hair or skin product, it is wise to patch test first to catch any unexpected sensitivities.

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