Bis-Hema Polycaprolactone Diol/Ipdi Copolymer: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
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All information on this page is verified using The Personal Care Products Council's (PCPC) INCI database. Our ingredient analyses are based exclusively on PCPC's technical data to ensure accuracy and reliability.

What Is Bis-Hema Polycaprolactone Diol/Ipdi Copolymer?

Bis-HEMA Polycaprolactone Diol/IPDI Copolymer is a lab-made polymer created by linking together three main building blocks: epsilon-caprolactone, diethylene glycol and isophorone diisocyanate. The caprolactone and diethylene glycol are first condensed to form a soft polyester chain, which is then reacted with isophorone diisocyanate to add strength and flexibility. Finally the ends of the chain are “capped” with HEMA (2-hydroxyethyl methacrylate) so the finished polymer can crosslink when exposed to light or heat. This chemistry gives the ingredient a balanced mix of toughness and flexibility that is ideal for nail formulas.

Polycaprolactone-based materials were originally explored in the 1970s for industrial coatings. As nail technicians looked for longer-lasting manicures in the 1990s, chemists adapted these coatings into cosmetic-grade polymers that cure quickly under UV or LED lamps. Bis-HEMA Polycaprolactone Diol/IPDI Copolymer emerged from that work and is now widely used in soak-off gels and hybrid lacquers.

You will most often see it listed on the ingredient label of gel polishes, nail strengtheners, builder gels and long-wear top coats. It may also appear in some nail treatment serums and base coats designed to add flexibility to brittle nails.

Bis-Hema Polycaprolactone Diol/Ipdi Copolymer’s Cosmetic Benefits/Uses

This ingredient serves a single, focused role in nail products.

• Nail conditioning: The polymer forms a thin yet durable film over the nail plate that helps lock in moisture, reduce surface peeling and protect the keratin layers from everyday wear. Its flexible backbone bends with the nail rather than cracking, so manicures last longer and natural nails feel less brittle after polish removal.

Who Can Use Bis-Hema Polycaprolactone Diol/Ipdi Copolymer

This nail conditioning polymer is gentle enough for all nail and skin types, including sensitive, dry, oily and combination. Because it stays on the nail plate rather than soaking deep into skin, it rarely causes problems for any specific group.

Bis-HEMA Polycaprolactone Diol/IPDI Copolymer is synthesized entirely from lab made raw materials and contains no animal-derived substances, so it is suitable for vegans and vegetarians.

Current research shows no link between the ingredient and harm to pregnant or breastfeeding women when used in normal nail products. Even so this is not medical advice and anyone who is pregnant or nursing should check with a healthcare professional before starting a new product.

The polymer does not increase photosensitivity and will not make skin or nails more prone to sunburn. It also plays well with other common nail ingredients like acrylics, plasticizers and colorants.

Potential Side Effects/Adverse Reactions

Reactions to topical Bis-Hema Polycaprolactone Diol/IPDI Copolymer can differ from person to person. The issues listed below are only potential side effects and most users will not run into them when the product is made and applied as directed.

  • Mild skin irritation around the nail folds if uncured gel touches the skin before lamp curing
  • Allergic contact dermatitis in individuals already sensitive to acrylate type ingredients
  • Nail plate thinning or peeling if products are over-filed or soaked off too frequently, though this is usually due to removal technique not the polymer itself
  • Temporary white spots on the nail surface caused by over-drying during acetone soak off

If any redness, itching or pain develops, stop using the product and consult a medical professional.

Comedogenic Rating

Rating: 0/5

Bis-HEMA Polycaprolactone Diol/IPDI Copolymer does not sink into facial pores or stay on skin; it sits on the hard nail surface and is removed with the polish. It contains no oily or waxy fractions that could clog pores, so it earns the lowest possible comedogenic rating.

That makes it perfectly fine for people prone to acne or breakouts.

Because it is cured under a lamp and then sealed, the finished film has almost no chance of transferring to the face, which further reduces any pore-clogging concern.

Summary

Bis-HEMA Polycaprolactone Diol/IPDI Copolymer is a lab-made nail conditioner that forms a strong yet flexible film to lock in moisture, cut peeling and help manicures last. It does this by crosslinking when exposed to UV or LED light, creating a tight net that bends with the nail instead of cracking.

The ingredient shows up most in gel polishes, builder gels and long-wear top coats, so it is well known in professional nail circles though the average shopper might not spot the name very often.

Safety data and decades of salon use point to a low risk profile when products are applied and removed correctly. Still, skin chemistry can vary, so it is wise to patch test any new nail formula that lists this polymer.

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