Bis-Hema Polyneopentyl Glycol Adipate/Ipdi Copolymer: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
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All information on this page is verified using publicly available nomenclature standards and reference materials from The Personal Care Products Council (PCPC) and the European Commission's CosIng database. Our analyses are based on technical data from these sources to ensure accuracy and reliability.

What Is Bis-Hema Polyneopentyl Glycol Adipate/Ipdi Copolymer?

Bis-Hema Polyneopentyl Glycol Adipate/Ipdi Copolymer is a synthetic polymer created by combining hexanedioic acid (also called adipic acid) with neopentyl glycol, isophorone diisocyanate and 2-hydroxyethyl methacrylate. The result is a long-chain molecule that forms a flexible yet durable film when it dries on the skin or nail surface. Chemists first explored this kind of copolymer in the late twentieth century while searching for lightweight, non-yellowing binders for coatings and nail products. It is produced through a step-growth polymerization process in which the acid and glycol react to form an adipate backbone, followed by incorporation of the diisocyanate to create urethane links. Finally, the methacrylate end groups are added to let the polymer cure quickly under light or air exposure. You will most often find this ingredient in gel nail polishes, long-wear nail lacquers, peel-off face masks, transfer-resistant makeup bases and certain waterproof brow or lash products.

Bis-Hema Polyneopentyl Glycol Adipate/Ipdi Copolymer’s Cosmetic Benefits/Uses

This ingredient serves mainly as a binder in cosmetic formulas. By forming an even film that locks pigments, shimmer or active ingredients in place it helps products adhere better to skin or nails, resist flaking and last longer through daily wear and washing.

Who Can Use Bis-Hema Polyneopentyl Glycol Adipate/Ipdi Copolymer

This polymer is generally suitable for all skin types because it forms a lightweight film that does not add extra oil or noticeable residue. Oily and acne-prone users often appreciate its non-greasy feel while dry or mature skin tolerates it well since it does not draw water out of the surface. Only those with a known sensitivity to acrylates or urethane compounds may need to be cautious because the cured film could still trigger rare contact irritation.

The ingredient is fully synthetic and contains no animal-derived substances, so it fits vegan and vegetarian lifestyles.

No research indicates that the cured polymer poses special risks to people who are pregnant or breastfeeding. This is not medical advice and anyone expecting or nursing should show their healthcare provider the full product ingredient list to confirm suitability.

Bis-Hema Polyneopentyl Glycol Adipate/Ipdi Copolymer is not known to cause photosensitivity, so it does not make skin more prone to sunburn. It also does not interfere with common active ingredients like vitamin C or retinoids, making it easy to layer with most routines.

Potential Side Effects/Adverse Reactions

Reactions to topical use of Bis-Hema Polyneopentyl Glycol Adipate/Ipdi Copolymer vary from person to person. The issues listed below are potential outcomes and are unlikely to affect the average user when the ingredient is properly formulated and fully cured in a finished product.

  • Mild skin irritation such as redness or itching, most commonly in people with pre-existing sensitivity to acrylates
  • Contact dermatitis after repeated exposure for individuals with a documented allergy to methacrylate or urethane compounds
  • Nail plate dryness or increased brittleness if the polymer film is removed aggressively from gel manicures
  • Eye discomfort or watering if particles from filing cured gel nails become airborne and reach the eyes

If any of these reactions occur stop using the product immediately and consult a healthcare professional for guidance.

Comedogenic Rating

Rating: 0 (non-comedogenic)

This ingredient is a large, high-molecular-weight polymer that forms an inert film on the surface of skin or nails rather than sinking into pores. It contains no oils or waxes that could trap sebum so it is extremely unlikely to clog pores. Because it is primarily used in nail products or makeup bases that dry down completely, contact with acne-prone areas tends to be minimal.

Suitable for those who are prone to breakouts.

The cured film may act as an occlusive layer in thick applications such as peel-off masks, but removal of the mask lifts the film away in one piece which further limits any pore blockage risk.

Summary

Bis-Hema Polyneopentyl Glycol Adipate/Ipdi Copolymer is a synthetic binder that improves adhesion, flexibility and wear time in products like gel nail polishes, long-wear makeup and peel-off masks. It accomplishes this by creating a lightweight yet durable polymer film that locks pigments and active ingredients in place while resisting water and everyday friction.

Although not a household name, it is quietly popular within professional nail formulas and some transfer-resistant cosmetics because it stays clear, does not yellow and cures quickly under light or air. Safety data show low irritation potential for most users and its non-comedogenic nature makes it friendly to acne-prone skin. As with any new cosmetic it is wise to patch test a small area first to rule out personal sensitivity.

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