Bis-(Methoxy Peg-100 Polyepsilon Caprolactone) Sebacate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
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All information on this page is verified using publicly available nomenclature standards and reference materials from The Personal Care Products Council (PCPC) and the European Commission's CosIng database. Our analyses are based on technical data from these sources to ensure accuracy and reliability.

What Is Bis-(Methoxy Peg-100 Polyepsilon Caprolactone) Sebacate?

Bis-(Methoxy PEG-100 Polyepsilon Caprolactone) Sebacate is a lab made block copolymer created by linking together segments of methoxylated polyethylene glycol, epsilon caprolactone, and sebacic acid. This gives it a long flexible chain that mixes well with water and oils. The ingredient first appeared in specialty skincare during the early 2000s when formulators began looking for new ways to trap moisture on the skin without leaving a greasy feel. To make it, chemists start with plant based or petroleum derived raw materials, run them through controlled polymerization steps, then purify the finished polymer into a soft waxy solid or viscous liquid. Its balanced structure lets it dissolve smoothly into creams, lotions, serums, sheet masks, overnight masks, hydrating primers, after sun gels and other leave on products that aim to boost skin hydration and comfort.

Bis-(Methoxy Peg-100 Polyepsilon Caprolactone) Sebacate’s Cosmetic Benefits/Uses

The ingredient acts as a humectant, meaning it draws water from the environment and the deeper layers of skin toward the surface. By pulling in this moisture it helps keep the outer skin layers plump, smooth and more elastic which can reduce the look of fine lines and rough patches. A strong humectant like Bis-(Methoxy PEG-100 Polyepsilon Caprolactone) Sebacate also enhances the spreadability of a formula making creams feel silkier and less heavy while improving overall skin comfort throughout the day.

Who Can Use Bis-(Methoxy Peg-100 Polyepsilon Caprolactone) Sebacate

This humectant is generally well tolerated by all skin types including dry, normal, combination and oily skin because it hydrates without leaving a heavy or occlusive film. Sensitive skin usually handles the ingredient well too since it is non-fragrant and has a large molecular size that keeps it mostly on the skin’s surface. The only group that might need extra caution is those with a history of polymer or PEG sensitivities, as the backbone of the molecule contains polyethylene glycol segments that could, in very rare cases, trigger irritation.

Bis-(Methoxy PEG-100 Polyepsilon Caprolactone) Sebacate is synthesized from plant based or petrochemical raw materials and contains no animal derived components so it is suitable for both vegans and vegetarians.

Current safety data show no specific risks for pregnant or breastfeeding women when the ingredient is used in leave on cosmetics at typical concentrations. This is not medical advice and anyone who is pregnant or nursing should have their healthcare provider review any skincare products they intend to use.

The polymer does not make skin more sensitive to sunlight and does not interfere with sunscreen filters so it carries no known risk of photosensitivity.

Potential Side Effects/Adverse Reactions

Reactions to topical Bis-(Methoxy Peg-100 Polyepsilon Caprolactone) Sebacate vary from person to person. The effects listed below are only potential outcomes and are unlikely to occur for the vast majority of users when the ingredient is included at normal cosmetic levels.

  • Mild skin irritation such as slight redness or itching
  • Transient stinging on very compromised or freshly exfoliated skin
  • Rare allergic contact dermatitis in individuals sensitized to PEG based materials
  • Possible increased absorption of other active ingredients leading to unexpected potency of those actives

If any unexpected reaction occurs discontinue use and consult a healthcare professional.

Comedogenic Rating

Rating: 0 / 5

Bis-(Methoxy PEG-100 Polyepsilon Caprolactone) Sebacate has a very low tendency to clog pores because it is a lightweight water-loving polymer that stays on the surface of the skin, creates no oily film and is used at modest percentages. Its large molecular size keeps it from nesting inside pores where blockages start. Therefore it is considered suitable for acne-prone or breakout-prone skin. At typical use levels it will not add to the oil burden of the skin or encourage blackheads.

No data suggest that it interacts with sebum oxidization or bacterial growth, so no hidden pore-clogging concerns are expected.

Summary

Bis-(Methoxy PEG-100 Polyepsilon Caprolactone) Sebacate is mainly a humectant that pulls water toward the outer skin layers, leaving skin feeling plump, smooth and more elastic. Its block-copolymer structure lets it mingle with both water and oil phases so it boosts the silky glide of creams while remaining light and non-greasy.

The ingredient is still something of a niche player compared with classics like glycerin or hyaluronic acid, yet formulators appreciate its unique sensory profile and it is beginning to show up in newer hydration-focused serums, masks and primers.

Current safety reviews report very low irritation or allergenic potential and no comedogenicity, making it a low-risk choice for most users including sensitive, oily and combination skin. As with any new skincare ingredient perform a simple patch test when trying a fresh product just to be on the safe side.

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