C12-14 Alkyl Diaminoethylglycine Hcl: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 24, 2025
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All information on this page is verified using publicly available nomenclature standards and reference materials from The Personal Care Products Council (PCPC) and the European Commission's CosIng database. Our analyses are based on technical data from these sources to ensure accuracy and reliability.

What Is C12-14 Alkyl Diaminoethylglycine Hcl?

C12-14 Alkyl Diaminoethylglycine Hcl is a specialty amino-acid–based ingredient derived from medium-chain fatty alcohols of coconut or palm oil that have 12 to 14 carbon atoms. Chemically it is the hydrochloride salt of 2-(2-(C12-14-alkyl)aminoethyl)aminoethylaminoacetic acid. Turning the raw fatty alcohols into this mild surfactant involves several steps: the fatty chains are first converted to amines, which are then reacted with glycine, followed by neutralization with hydrochloric acid to create a stable, water-soluble powder or liquid. The material was developed in the late 1990s as formulators looked for gentler, plant-based alternatives to traditional sulfates. Its balanced charge and amino-acid backbone make it less irritating and more biodegradable than many earlier cleansers, so it quickly found a place in personal care labs. Today you will spot C12-14 Alkyl Diaminoethylglycine Hcl in facial cleansers, micellar waters, sulfate-free shampoos, body washes, hand soaps, shaving foams, makeup removers and even some lightweight moisturizers that double as rinse-off masks.

C12-14 Alkyl Diaminoethylglycine Hcl’s Cosmetic Benefits/Uses

Formulators choose this ingredient because it offers several helpful actions in one package

  • Cleansing: Its gentle surfactant structure lifts away excess oil, dirt and makeup while respecting the skin’s natural barrier, making products feel mild yet effective
  • Emulsifying: It helps oil and water blend smoothly, so creams stay stable, foams hold their texture and clear gels remain uniform over shelf life

Who Can Use C12-14 Alkyl Diaminoethylglycine Hcl

This mild surfactant is generally well tolerated by all skin types, including sensitive, oily, dry and combination skin. Because it cleans without stripping natural oils it tends to suit easily irritated or compromised skin particularly well. There are no known reasons for acne-prone or mature skin to avoid it.

Most suppliers obtain the fatty alcohols from coconut or palm sources so the raw material is plant based and free of animal ingredients, making it suitable for vegans and vegetarians. If strict vegan standards are important look for brands that certify the entire formula rather than the single ingredient.

Current research shows no specific risks for women who are pregnant or breastfeeding when the ingredient is used in rinse-off or leave-on cosmetics. Still, this is not medical advice and anyone who is pregnant or nursing should review the full product with a healthcare professional before adding it to a routine.

C12-14 Alkyl Diaminoethylglycine Hcl does not cause photosensitivity and will not make skin more prone to sunburn. It is also odorless so it is unlikely to clash with fragrance sensitives.

Potential Side Effects/Adverse Reactions

Reactions to topical C12-14 Alkyl Diaminoethylglycine Hcl vary from person to person. The points below list potential side effects that could occur, though they are uncommon when the ingredient is used correctly in finished products.

  • Mild skin irritation – very sensitive skin may feel temporary redness or stinging, usually if the product is left on too long or used in high concentration
  • Eye irritation – as with most cleansers contact with the eyes can cause watering or a slight burn that subsides after rinsing with water
  • Dryness or tightness – over-cleansing can remove too much surface oil leading to a dry feel, especially in low humidity climates
  • Allergic contact dermatitis – rare but possible for individuals allergic to the amino-acid derivative or other formula components

If any persistent burning, rash or swelling develops discontinue use and seek advice from a medical professional.

Comedogenic Rating

Rating: 0 / 5

C12-14 Alkyl Diaminoethylglycine Hcl is a fully water-soluble amino acid surfactant that rinses off completely and leaves no oily or waxy film behind, so it does not linger in pores or trap dead skin cells. It also has a relatively low molecular weight and is used at modest levels in finished products, further reducing any chance of clogging. For these reasons its comedogenic rating is considered zero.

Because it is non-pore-clogging, the ingredient is generally suitable for people who struggle with acne or frequent breakouts.

The only time it might indirectly contribute to blemishes is if a formula pairs it with heavier oils or butters that sit on the skin, so check the overall product if you are highly acne-prone.

Summary

C12-14 Alkyl Diaminoethylglycine Hcl is a plant-derived surfactant that mainly cleanses and emulsifies. Its amino acid backbone lifts away oil and debris while its balanced charge helps water and oil mix so formulas stay smooth and rinse easily. Thanks to this multitasking profile it pops up in gentle face washes, micellar waters, sulfate-free shampoos and even hybrid moisturizers, though it is still less common than big-name cleansers like cocamidopropyl betaine or sodium laureth sulfate.

Overall safety data are strong with low irritation potential and no evidence of comedogenicity or long-term health risks. As with any new cosmetic we suggest patch testing a small area before full use to make sure your skin gets along with the complete formula.

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