What Is Caffeine Carboxyloyl Tripeptide-37?
Caffeine Carboxyloyl Tripeptide-37 is a lab crafted molecule that joins a caffeine-derived acid with a short chain of three amino acids known as Tripeptide-37. The resulting hybrid keeps the energizing elements of caffeine while adding the skin friendly profile of a peptide. This ingredient first appeared in specialty skin care labs in the early 2010s as chemists searched for milder peptide options that could pair well with popular actives like caffeine. The reaction process involves converting caffeine into a carboxylic acid form, then bonding it to the tripeptide using controlled pH and temperature steps that lock the two parts together without harsh solvents. You will usually spot Caffeine Carboxyloyl Tripeptide-37 in lightweight serums, eye creams, sheet masks, gel moisturizers and targeted anti aging treatments that promise smoother, more refreshed looking skin.
Caffeine Carboxyloyl Tripeptide-37’s Cosmetic Benefits/Uses
Formulators reach for this ingredient largely for its skin conditioning talent, which can translate to a healthier feel and appearance on the surface of the skin. By supporting the skin’s natural moisture barrier and promoting a soft touch finish, it helps products deliver a comfortable, well hydrated result without heaviness.
Who Can Use Caffeine Carboxyloyl Tripeptide-37
This peptide-caffeine hybrid sits comfortably in formulas made for dry, oily, combination and sensitive skin. It is lightweight, non occlusive and generally non comedogenic, so it does not clog pores or leave a greasy film. People with very reactive or allergy prone skin can still try it because it lacks common irritants like fragrance, alcohol or essential oils. No particular skin type needs to avoid it, although anyone who knows they are sensitive to caffeine in topical form may wish to proceed with extra caution.
Caffeine Carboxyloyl Tripeptide-37 is produced in a lab without animal derived materials, so it is suitable for both vegans and vegetarians.
Current safety data shows no specific risks for pregnant or breastfeeding individuals when the ingredient is applied to skin. That said this is not medical advice, and anyone who is pregnant or nursing should check with their healthcare provider before adding new skincare products, just to stay on the safe side.
The ingredient does not increase photosensitivity, so routine sun exposure precautions remain unchanged. There are no known issues with using it alongside other common actives such as niacinamide, hyaluronic acid or vitamin C.
Potential Side Effects/Adverse Reactions
Side effects and reactions to topical Caffeine Carboxyloyl Tripeptide-37 vary from person to person. The points below list potential outcomes that are possible yet unlikely when the product is well formulated and used as directed.
- Mild redness or flushing
- Temporary tingling or warmth on application
- Itching or mild irritation in sensitive individuals
- Rare allergic contact dermatitis presenting as rash or swelling
- Exacerbation of existing rosacea in those who are highly reactive to caffeine
If any negative effect occurs stop using the product immediately and seek advice from a qualified healthcare professional.
Comedogenic Rating
Rating: 1 / 5 – Caffeine Carboxyloyl Tripeptide-37 is a small, water-soluble molecule that does not leave an oily residue or form a heavy film on the skin. It is typically delivered in lightweight serums and gels that rinse or absorb cleanly, so there is little chance of it trapping dead cells or excess sebum inside pores. This makes it a low-risk option for people who are prone to blackheads or breakouts.
Suitable for acne-prone skin in most cases.
Formulators sometimes pair this peptide with richer emollients; if a breakout occurs it is more likely due to the overall formula rather than the peptide itself.
Summary
Caffeine Carboxyloyl Tripeptide-37 conditions skin by blending the soothing, moisture-supporting qualities of a peptide with the energizing feel of caffeine. It helps maintain barrier comfort, gives a soft after-touch and pairs well with common actives without causing instability.
While not yet a household name, it has carved out a niche in modern eye creams, sheet masks and lightweight anti-aging serums because it offers peptide benefits without heaviness.
Current research and consumer use point to a high safety profile with minimal irritation risk. As with any new skincare ingredient it is smart to patch test first to confirm personal compatibility.