What Is Caffeoyl Hexapeptide-48?
Caffeoyl Hexapeptide-48 is a lab-created molecule formed by linking caffeic acid, a plant-derived antioxidant compound, with a chain of six amino acids known as Hexapeptide-48. This hybrid design blends the free-radical fighting power of caffeic acid with the skin-communicating abilities of a peptide. The concept emerged in the early 2010s when formulators began pairing botanical antioxidants with short peptides to boost skin resilience while keeping formulas gentle.
The ingredient is produced through a controlled reaction: first the hexapeptide is synthesized using standard peptide chemistry, then caffeic acid is attached to one end of the chain. The finished material is purified, dried and supplied as a fine powder that is easily dispersed in water-based or mixed-phase cosmetic systems.
Because it offers both antioxidant defense and peptide-driven skin support, Caffeoyl Hexapeptide-48 shows up in a range of leave-on products. You will most often find it in anti-aging serums, lightweight moisturizers, targeted eye creams, sheet masks and protective day creams aimed at urban stress or pollution exposure.
Caffeoyl Hexapeptide-48’s Cosmetic Benefits/Uses
Formulators choose this dual-action ingredient to give products an edge in defending and fortifying the skin
- Antioxidant: Helps neutralize free radicals generated by UV light or pollution which can otherwise speed up the look of aging, dullness and uneven tone. By reducing oxidative stress it supports a calmer brighter complexion
- Skin Protecting: Reinforces the skin’s barrier function so it can hold moisture better and stay resilient against daily environmental aggressors. This makes formulas feel more comforting and can reduce visible signs of irritation over time
Who Can Use Caffeoyl Hexapeptide-48
This ingredient is generally considered friendly for all skin types. Its lightweight water-soluble nature suits oily and combination skins, while the barrier-supporting peptide side appeals to dry or mature complexions. People with sensitive or reactive skin usually tolerate it well because it has a low irritation profile, although anyone with a known sensitivity to caffeic acid or phenolic compounds may wish to proceed cautiously.
Caffeoyl Hexapeptide-48 is produced through synthetic peptide chemistry with caffeic acid that can be sourced from plants, so it is typically suitable for vegans and vegetarians. As always formulation specifics and brand ethics should be checked if cruelty-free status is important to you.
No published data link this ingredient to problems during pregnancy or breastfeeding. That said safety testing on these groups is limited so this content is not medical advice and pregnant or nursing individuals should ask a healthcare professional before adding any new skincare product.
The molecule does not induce photosensitivity. Standard daytime protection with sunscreen is still recommended for overall skin health but there is no special sun-avoidance requirement tied to this ingredient.
Potential Side Effects/Adverse Reactions
Response to topical Caffeoyl Hexapeptide-48 can vary from person to person. The effects listed below are potential outcomes and are unlikely for most users when the ingredient is properly formulated and used as directed.
- Mild redness or warmth at the application site
- Temporary stinging or tingling, especially on compromised skin
- Itchiness or small bumps in individuals sensitive to caffeic acid derivatives
- Allergic contact dermatitis presenting as persistent rash or swelling
- Rare discoloration of very fair skin if combined with highly acidic products
If you experience any of these reactions stop using the product and consult a qualified healthcare provider.
Comedogenic Rating
Rating: 0-1 (very low)
Caffeoyl Hexapeptide-48 is a small water soluble molecule that is used at low percentages and does not create an occlusive film, so it is highly unlikely to block pores.
This makes it a good option for people who are prone to acne or frequent breakouts.
Its comedogenic profile can change if paired with heavy oils, waxes or butters, so always consider the whole formula rather than the single ingredient.
Summary
Caffeoyl Hexapeptide-48 pairs the antioxidant punch of caffeic acid with a six amino acid peptide giving it the ability to mop up free radicals then signal the skin to strengthen its barrier and retain moisture.
By cutting oxidative stress and boosting resilience it helps skin look calmer brighter and better hydrated over time.
While not as famous as vitamin C or niacinamide the ingredient is gaining traction in next generation serums eye creams and anti pollution moisturizers because it offers two benefits in one lightweight package.
Studies and user reports show a very low irritation rate, yet every complexion is different so patch testing a new product that features Caffeoyl Hexapeptide-48 is still the smartest approach.