What Is Caffeoyl Sh-Heptapeptide-13?
Caffeoyl Sh-Heptapeptide-13 is a lab-crafted molecule that joins a short chain of seven amino acids with a caffeoyl group derived from coffee plant compounds. This hybrid structure blends the skin-friendly nature of peptides with the antioxidant kick of plant polyphenols. The idea of pairing peptides with antioxidants gained traction in the early 2000s as formulators searched for multitasking ingredients that could protect skin while supporting its natural repair processes. By reacting caffeoyl chloride with Sh-Decapeptide-13, chemists shorten the original peptide to a heptapeptide and attach the caffeoyl group, resulting in a stable, water-soluble powder that dissolves easily into creams and serums.
The ingredient is synthesized in controlled laboratory settings, where peptide chains are first built step by step, then purified. The caffeoyl component is added in a final coupling reaction, and the finished material goes through filtration and drying before it is ready for cosmetic use.
Thanks to its dual nature, Caffeoyl Sh-Heptapeptide-13 shows up in lightweight anti-aging serums, daily moisturizers, sheet masks, eye creams and after-sun gels. Brands often highlight it as a next-generation antioxidant peptide that helps maintain a fresh, resilient complexion.
Caffeoyl Sh-Heptapeptide-13’s Cosmetic Benefits/Uses
In formulas, this ingredient focuses on protection and upkeep of skin health.
- Antioxidant: Helps neutralize free radicals created by pollution and UV exposure, which may slow the look of premature aging and keep skin tone more even.
- Skin protecting: Supports the skin barrier by calming environmental stress, reducing the chance of dryness or dullness and leaving the complexion feeling comfortable.
Who Can Use Caffeoyl Sh-Heptapeptide-13
This antioxidant peptide is considered gentle and lightweight so it generally suits most skin types including dry, oily, combination and mature skin. Its water-soluble nature means it does not leave an occlusive film, making it comfortable even for breakout-prone or sensitive complexions. No specific skin type is discouraged from using it, though anyone with a history of allergy to peptides or coffee-derived compounds should stay cautious.
The molecule is produced in a laboratory using synthetic amino acids and a plant-derived caffeoyl group. Because no animal-origin materials are required during standard manufacturing, it is usually classified as vegan and vegetarian friendly. Still, strict vegans may wish to confirm that the brand’s supply chain avoids animal testing and uses plant or synthetic sources for every processing aid.
There is no evidence that Caffeoyl Sh-Heptapeptide-13 poses a risk to women who are pregnant or breastfeeding when applied topically in cosmetic concentrations. This is not medical advice and anyone expecting or nursing should run new skincare products past a qualified healthcare provider to be on the safe side.
The ingredient is an antioxidant so it does not increase photosensitivity. Daily sunscreen is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to topical Caffeoyl Sh-Heptapeptide-13 can vary from person to person. The effects listed below are possible yet unlikely for most users when the ingredient is correctly formulated and used as directed.
- Mild redness or stinging immediately after application
- Itchiness in individuals sensitive to peptides or coffee-derived compounds
- Contact dermatitis in rare cases of allergy
- Eye irritation if the product accidentally gets into the eyes
If any of these reactions occur discontinue use and seek medical advice if symptoms persist or worsen.
Comedogenic Rating
Rating: 0 / 5. Caffeoyl Sh-Heptapeptide-13 is a small, water-soluble peptide with no oily or waxy residues, so it does not clog pores or sit on the skin surface. Its antioxidant caffeoyl group is also lightweight and non-film-forming.
Because it scores a zero, the ingredient is generally suitable for people who are prone to acne or breakouts.
Formulas that combine this peptide with heavier emollients could still feel rich, so always check the overall product texture if you are very pore-clogging sensitive.
Summary
Caffeoyl Sh-Heptapeptide-13 serves mainly as an antioxidant and skin-protecting agent. The caffeoyl part donates electrons to neutralize free radicals while the heptapeptide segment signals skin to bolster its natural barrier, helping maintain firmness and hydration.
It is a niche but growing ingredient, often highlighted in mid- to high-end serums and eye creams for its dual action without adding heaviness.
Current data show it is safe for topical use with a low risk of irritation or pore blockage. As with any new skincare addition, perform a quick patch test to ensure personal compatibility before full-face application.