What Is Capsaicinyl Succinoyl Tripeptide-35?
Capsaicinyl Succinoyl Tripeptide-35 is a lab crafted peptide joined to a tiny portion of capsaicin, the active component that gives chili peppers their heat. By linking a mild form of capsaicin to a short chain of three amino acids, chemists create a molecule that stays gentle on skin yet carries useful protective properties. The addition of succinic acid helps stabilize the structure so it blends well with creams and serums.
The ingredient emerged in the early 2010s when formulators searched for new ways to calm environmental stress on skin without causing irritation. Advances in peptide synthesis allowed the capsaicin fragment to be precisely attached, keeping the final material non-sting and suitable for daily use.
Production starts with fermenting plant-derived sugars to make succinic acid, then synthesizing the tripeptide through standard peptide coupling. A purified, low-heat capsaicin derivative is hooked onto the peptide, followed by filtration and drying to yield a fine powder ready for cosmetic labs.
You will typically spot Capsaicinyl Succinoyl Tripeptide-35 in lightweight anti-aging serums, protective day creams, overnight masks, post-sun soothing gels and high-performance moisturizers where brands want an extra boost of antioxidant support.
Capsaicinyl Succinoyl Tripeptide-35’s Cosmetic Benefits/Uses
This multitasking peptide brings two key advantages to skin care formulas
- Antioxidant – helps neutralize free radicals created by pollution or UV exposure which can otherwise speed up visible aging. Regular use supports a brighter, fresher looking complexion
- Skin protecting – forms a lightweight shield that reinforces the skin barrier, reducing moisture loss and lowering the chance of irritation from daily environmental aggressors
Who Can Use Capsaicinyl Succinoyl Tripeptide-35
This peptide is generally well tolerated by all major skin types including dry, normal, combination and oily skin. Its soothing design means even sensitive complexions usually accept it without fuss, though anyone with a known allergy to chili peppers or capsaicin derivatives should avoid it as a precaution.
The raw materials come from plant fermentation and lab synthesis so the finished ingredient is free from animal by-products, making it suitable for vegans and vegetarians.
No specific warnings exist for pregnant or breastfeeding women, yet safety data in these groups is limited. This text is not medical advice. Expectant or nursing mothers should show the full ingredient list of any product to their doctor before use.
Capsaicinyl Succinoyl Tripeptide-35 does not increase photosensitivity. Daily sunscreen is still a good idea for overall skin health, but you do not need extra sun precautions solely because of this ingredient. It also plays nicely with most common actives like niacinamide, hyaluronic acid and gentle retinoids.
Potential Side Effects/Adverse Reactions
Responses to topical Capsaicinyl Succinoyl Tripeptide-35 differ from person to person. The points below outline potential effects that may occur, but most users will not experience them when products are formulated and used correctly.
- Mild warmth or tingling
- Temporary redness that fades within minutes
- Stinging if applied on broken or freshly exfoliated skin
- Allergic reaction in individuals sensitive to capsaicin or pepper extracts
- Eye irritation if the product is rubbed into the eye area
If any unwanted reaction develops stop using the product and consult a healthcare professional or dermatologist for guidance.
Comedogenic Rating
Rating: 0. Capsaicinyl Succinoyl Tripeptide-35 is a small, water-soluble peptide that leaves no oily residue, contains no pore-clogging waxes or butters and is generally used at very low concentrations, so it does not block follicles. This makes it suitable for people who are prone to acne or breakouts. When blended into richer creams the overall formula, not the peptide itself, will determine clogging potential, so always check the complete ingredient list.
Summary
Capsaicinyl Succinoyl Tripeptide-35 works as an antioxidant and skin-protecting agent. The capsaicin fragment helps mop up free radicals while the tripeptide portion signals skin to reinforce its barrier, together helping skin stay calm, hydrated and resilient. It is still a niche ingredient found mainly in higher-end serums and creams, so you may not see it in every drugstore aisle yet its popularity is gradually growing as brands look for gentle multifunctional actives.
Current data shows it is safe for most users with only mild, short-lived warmth reported in a small number of cases. As with any new skincare ingredient it is smart to patch test first so you can spot rare sensitivities before applying over a larger area.