Carboxymethyl Dextran: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 24, 2025
Share:
Inside this article:

All information on this page is verified using The Personal Care Products Council's (PCPC) INCI database. Our ingredient analyses are based exclusively on PCPC's technical data to ensure accuracy and reliability.

What Is Carboxymethyl Dextran?

Carboxymethyl Dextran is a plant-based sugar polymer that has been lightly modified to improve its use in skin care. It starts with dextran, a long chain of glucose units that is naturally made by certain non-harmful bacteria during the fermentation of sugar. Chemists react this dextran with chloroacetic acid, swapping some of the natural hydroxyl groups for carboxymethyl groups. The result is a water-soluble powder that swells and thickens when mixed with water.

The first commercial forms of dextran appeared in the 1940s as blood plasma substitutes. Once its safety and gentle nature were clear labs began tweaking the molecule and by the late 1960s carboxymethyl dextran found its way into personal care labs as a plant-derived thickener. Today manufacturers produce it in closed stainless-steel reactors where purified dextran is mixed with the carboxymethyl agent under controlled heat and pH then filtered and spray-dried to a fine white powder.

You will most often see carboxymethyl dextran in leave-on formulas such as serums anti-aging creams eye gels sheet masks and even some color cosmetics that need a smooth flexible film. It is also common in rinse-off products like hydrating cleansers and soothing wash-off masks because it helps create a rich cushiony texture.

Carboxymethyl Dextran’s Cosmetic Benefits/Uses

This ingredient earns its place in a formula by doing several helpful jobs at once

  • Bulking – Adds substance to a formula so lightweight actives are easier to weigh blend and dose giving the finished product a consistent feel from batch to batch
  • Film Forming – Creates a thin breathable layer on the skin that locks in moisture smooths fine lines and boosts the staying power of makeup
  • Gel Forming – Swells in water to create a soft gel that holds water next to the skin offering an instant plumping effect and a pleasant cushioned glide
  • Viscosity Controlling – Allows chemists to dial in the exact thickness they want whether that is a light fluid serum or a richer cream improving spreadability and user experience

Who Can Use Carboxymethyl Dextran

Thanks to its gentle plant derived nature Carboxymethyl Dextran suits most skin types including dry, normal, oily and sensitive. It adds hydration without clogging pores and its flexible film helps reduce moisture loss so even easily irritated or compromised skin can usually tolerate it well. There are no known reasons for eczema prone or acne prone users to avoid it.

The ingredient comes from fermented plant sugars and no animal inputs are used during manufacture so it meets vegan and vegetarian standards.

Current data shows no reproductive or developmental concerns from topical use which means products containing it are generally considered safe for those who are pregnant or breastfeeding. This is not medical advice and anyone who is expecting or nursing should still run their skincare routine past a health care professional just to be safe.

Carboxymethyl Dextran does not make skin more sensitive to sunlight and it will not interfere with sunscreen performance. It also plays nicely with common actives like retinoids, vitamin C and exfoliating acids because it is chemically neutral and does not alter pH in finished formulas.

Potential Side Effects/Adverse Reactions

Responses to any cosmetic ingredient can vary from person to person. The points below list potential issues but they are uncommon when Carboxymethyl Dextran is used at typical skincare levels

  • Mild redness or itching in extremely sensitive individuals
  • Transient stinging if applied to freshly exfoliated or broken skin
  • Rare allergic contact dermatitis in those with a specific dextran sensitivity
  • Ingredient build up leading to a tight feeling when layered with multiple film formers

If any discomfort swelling or persistent irritation occurs discontinue use and seek guidance from a qualified medical professional

Comedogenic Rating

Rating: 0

Carboxymethyl Dextran is a large water soluble sugar polymer that sits on the surface in a breathable film and easily rinses away. It has no oils or waxy residues that can plug pores which is why formulators classify it as non comedogenic. Its molecular weight keeps it from penetrating the follicle so it does not build up inside pores.

Because of this rating it is generally suitable for skin that is prone to acne or breakouts.

One note for heavy makeup users: stacking several film formers in the same routine can still lead to a tight feeling or layered residue so thorough cleansing at the end of the day is advised.

Summary

Carboxymethyl Dextran is a plant derived thickener that bulks up formulas, forms a flexible moisture trapping film, gels water for a plush skin feel and lets chemists fine tune viscosity. It performs these jobs by swelling in water and linking into a lightweight network that holds actives in place on the skin surface.

You will spot this ingredient in a fair number of modern serums, eye gels and sheet masks though it is not as famous as hyaluronic acid or xanthan gum. Brands choose it when they want a smooth non sticky finish and reliable texture control.

Safety data shows it is very gentle with low risk of irritation or pore clogging. As with any new product a quick patch test is wise to confirm individual tolerance before full face use.

Was this article helpful?
More from Glooshi:
ADVERTISEMENT
Get all our top headlines in beauty.
Delivered right to your inbox each week. Zero spam, all goodness, opt-out at anytime.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Get the latest beauty news, top product recommendations & brand-exclusive discount codes direct to your inbox.
Send good feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Send bad feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Search