Ceteth-45: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 24, 2025
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All information on this page is verified using The Personal Care Products Council's (PCPC) INCI database. Our ingredient analyses are based exclusively on PCPC's technical data to ensure accuracy and reliability.

What Is Ceteth-45?

Ceteth-45 is a synthetic compound made by attaching about forty five units of ethylene oxide to cetyl alcohol, a fatty alcohol usually sourced from coconut or palm oil. This process, known as ethoxylation, turns the waxy cetyl alcohol into a water-loving substance that can mix oil and water with ease. Chemists first explored this type of technology in the mid-20th century when the beauty industry was looking for safer, gentler alternatives to harsh soaps. Over time Ceteth-45 earned a place in skin and hair formulas because it helped products rinse away dirt without stripping the skin’s natural moisture.

Manufacturing starts with purified cetyl alcohol. The alcohol is reacted with ethylene oxide gas under controlled heat and pressure until the desired average of forty five oxyethylene units attaches to each alcohol molecule. The finished ingredient appears as a soft solid or thick paste that melts into liquids when warmed.

Thanks to its cleansing and emulsifying talents you will often find Ceteth-45 in facial cleansers, micellar waters, exfoliating masks, makeup removers, body washes, shampoo, conditioner and even shave creams. In these products it helps oils, impurities and leftover makeup lift away while keeping the formula stable and smooth.

Ceteth-45’s Cosmetic Benefits/Uses

Ceteth-45 brings one key benefit to personal care products

Cleansing: The ingredient acts like a gentle detergent, loosening the bond between oil-based grime and the skin or hair surface so they can be rinsed away with water. This helps a cleanser leave you feeling fresh yet comfortable, avoiding the tight or squeaky sensation harsh soaps can cause.

Who Can Use Ceteth-45

Ceteth-45 is generally well tolerated by most skin types. Its mild cleansing action suits oily, combination and normal skin, and because it is less stripping than traditional soaps many people with dry or sensitive skin can also use it comfortably. Those with very compromised or eczema-prone skin should monitor for any extra dryness since any surfactant can remove some surface lipids.

The ingredient itself can be produced from plant or animal sources. Most modern suppliers use coconut or palm-derived cetyl alcohol, which makes Ceteth-45 suitable for vegans and vegetarians. Anyone following a strict plant-only lifestyle may still wish to confirm the feedstock with the manufacturer.

No specific warnings exist for pregnant or breastfeeding women. Current safety data show no reproductive or developmental risks when Ceteth-45 is used on the skin. Still, this information is not medical advice, and anyone who is expecting or nursing should ask a healthcare professional before starting a new product.

Ceteth-45 does not increase photosensitivity, so it will not make skin more prone to sunburn. It is also compatible with common actives like retinol or vitamin C and does not interfere with their performance.

Potential Side Effects/Adverse Reactions

Responses to topical Ceteth-45 differ from person to person. The effects listed below are possible but uncommon when the ingredient is used correctly in finished products.

  • Skin irritation – redness, stinging or a mild burning sensation, most often in people with very sensitive or damaged skin
  • Contact allergy – rare cases of allergic contact dermatitis marked by itching, rash or swelling after repeated exposure
  • Excess dryness – feeling of tightness if the cleanser is left on too long or used too frequently
  • Eye irritation – temporary tearing or discomfort if the product splashes into the eyes
  • Breakouts – occasional clogged pores if residue is not rinsed off completely, especially on acne-prone skin

If any of these reactions occur stop using the product and consult a healthcare professional for guidance.

Comedogenic Rating

Rating: 1/5. Ceteth-45 is a large, water-soluble surfactant that rinses off easily, so it rarely lingers on the skin long enough to clog pores. It lacks the heavy, oily texture common to more comedogenic ingredients, which keeps the risk of blocked follicles low.

Because of this low score, most people prone to acne or breakouts can use products containing Ceteth-45 without major concern.

As with any cleanser, thorough rinsing helps prevent residue that could mix with other occlusive ingredients and raise the chance of congestion.

Summary

Ceteth-45’s main job is to cleanse and emulsify. By pairing a fatty cetyl tail with a chain of ethylene oxide units, the molecule grabs onto oil and dirt with its lipophilic end while its hydrophilic side pulls those impurities into water so they wash away smoothly.

It is a quiet workhorse rather than a headline ingredient. You will see it scattered through face washes, shampoos and makeup removers where formulators need gentle but effective cleansing without a greasy afterfeel.

Safety profiles show it is generally well tolerated with a low risk of irritation or pore clogging. Still, skin can react unpredictably, so it is smart to patch test any new product containing Ceteth-45 before full use.

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