Cetoleth-25: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 24, 2025
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All information on this page is verified using The Personal Care Products Council's (PCPC) INCI database. Our ingredient analyses are based exclusively on PCPC's technical data to ensure accuracy and reliability.

What Is Cetoleth-25?

Cetoleth-25 is a nonionic surfactant made by attaching, on average, twenty-five units of ethylene oxide to long-chain fatty alcohols that mainly contain 16 to 18 carbon atoms, many of which are naturally unsaturated. These fatty alcohols are usually sourced from plant oils such as coconut, palm or rapeseed, making the ingredient readily renewable. First introduced to personal care labs in the late 1970s as formulators searched for milder cleansing agents, Cetoleth-25 quickly gained popularity for its ability to mix oil and water without irritating skin. Production begins with the fatty alcohols, which are reacted with ethylene oxide under carefully controlled heat and pressure until the desired degree of ethoxylation is reached, resulting in a waxy, water-dispersible substance. You will most often spot Cetoleth-25 in facial cleansers, creamy body washes, shampoo, micellar waters, makeup removers and some rinse-off masks where it helps create a smooth, uniform texture while boosting the product’s ability to lift away grime.

Cetoleth-25’s Cosmetic Benefits/Uses

In skincare and haircare formulas Cetoleth-25 serves one primary role that offers several advantages.

Cleansing: As a mild surfactant it lowers the surface tension between oil and water so dirt, makeup and excess sebum can be suspended and washed away. This improves the overall cleansing power of a product while maintaining a soft, creamy feel and reducing the risk of dryness compared with harsher detergents.

Who Can Use Cetoleth-25

Cetoleth-25 is generally well tolerated by most skin types including normal, oily, combination and even many sensitive skins because of its mild cleansing action. Very dry or compromised skin may prefer formulas where Cetoleth-25 is paired with richer emollients to offset possible moisture loss.

The fatty alcohols used to make Cetoleth-25 are typically sourced from plant oils so products containing it are usually suitable for vegans and vegetarians unless other animal-derived ingredients are present in the same formula. Checking a brand’s full ingredient list or its cruelty-free statement can confirm this.

No research shows that topical Cetoleth-25 poses a special risk to pregnant or breastfeeding women. Still, this is not medical advice and anyone who is pregnant or nursing should ask a healthcare professional before adding new skincare to be safe.

Cetoleth-25 does not increase the skin’s sensitivity to sunlight so it is not considered photosensitising. It also plays well with most other common skincare ingredients making it a versatile choice in cleansers and makeup removers.

Potential Side Effects/Adverse Reactions

Responses to Cetoleth-25 can differ from person to person. The points below list potential side effects that are possible but not expected for the average user when the ingredient is used correctly in finished products.

  • Mild skin irritation such as temporary stinging or burning
  • Redness or tightness especially on very dry or compromised skin
  • Allergic contact dermatitis in individuals sensitive to ethoxylated compounds
  • Eye irritation if the cleanser accidentally gets into the eyes
  • Excessive dryness when used in high concentrations or with other strong surfactants

If any of these reactions occur discontinue use and consult a healthcare professional if symptoms persist or worsen.

Comedogenic Rating

Rating: 1/5

Cetoleth-25 is an ethoxylated fatty alcohol that is almost always used in rinse-off products like cleansers and shampoos. Its large, water-loving structure keeps it from lingering in pores and the short contact time during cleansing further limits any buildup. Because of this it has very low potential to clog pores, earning it a score of 1 rather than a perfect zero.

Suitable for acne-prone or breakout-prone skin in most cases

Worth noting: if a formula combines Cetoleth-25 with heavy oils or waxes the overall product may feel more occlusive which could raise the pore-clogging risk even though Cetoleth-25 itself remains low on the scale.

Summary

Cetoleth-25 is mainly valued as a mild cleansing agent that helps water mix with oil so dirt, makeup and excess sebum can be lifted off skin or hair. By binding to both oil and water it boosts the cleaning power of facial washes, body washes, micellar waters and shampoos while keeping the texture creamy and pleasant.

Although not as famous as sodium laureth sulfate or coco-glucoside, Cetoleth-25 still appears in a good number of gentle cleansers thanks to its balance of effectiveness and softness.

The ingredient has a strong safety record with low irritation and almost no pore-clogging risk when used as directed. As with any new skincare product it is smart to perform a quick patch test to make sure your individual skin agrees with the finished formula.

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