Cetyloxypropyl Glyceryl Methoxypropyl Myristamide: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 24, 2025
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All information on this page is verified using The Personal Care Products Council's (PCPC) INCI database. Our ingredient analyses are based exclusively on PCPC's technical data to ensure accuracy and reliability.

What Is Cetyloxypropyl Glyceryl Methoxypropyl Myristamide?

Cetyloxypropyl Glyceryl Methoxypropyl Myristamide is a lab made fatty amide created by linking parts of fatty acids like myristic acid with glycerin and cetyl alcohol. The result is a creamy oily substance that blends well with both water and oil phases in a formula. It was first explored in the early 2000s when chemists were looking for softer feeling replacements for plain plant oils. By tweaking the natural building blocks they produced a more stable ingredient that holds up better in jars and tubes.

Today the compound is produced through a controlled reaction that starts with vegetable based fatty acids. These are combined with glycerin and methoxypropyl groups in several heating and mixing steps, then purified to remove any leftover raw materials. The finished material is a pale waxy liquid that melts at skin temperature and spreads easily.

You will most often spot Cetyloxypropyl Glyceryl Methoxypropyl Myristamide in moisturizers, night creams, anti aging serums, rinse off masks and soothing balms. It is prized for the soft cushiony after feel it gives and its ability to lock in water without leaving a heavy film.

Cetyloxypropyl Glyceryl Methoxypropyl Myristamide’s Cosmetic Benefits/Uses

This ingredient earns its place on an ingredient list because it delivers a few key skin feel perks.

  • Skin Conditioning: It forms a light breathable layer that helps keep water inside the skin so it feels smooth and supple through the day
  • Emollient: Its silky texture fills in tiny gaps between skin cells making rough areas feel softer while adding immediate slip to creams and lotions

Who Can Use Cetyloxypropyl Glyceryl Methoxypropyl Myristamide

This silky emollient is generally well tolerated by all skin types. Dry and mature skin tend to benefit most from the extra cushion and moisture retention it provides while oily or combination skin usually appreciate its light feel that does not leave a greasy finish. Extremely acne-prone users should still keep an eye on how their skin responds since any rich lipid can sometimes feel too occlusive for them.

The ingredient is synthesized from plant-derived fatty acids so it is suitable for vegans and vegetarians. No animal by-products or animal testing are required for its production.

Current safety data show no issues for pregnant or breastfeeding women when the ingredient is used topically at the small amounts found in cosmetics. This is not medical advice and anyone who is pregnant or nursing should double-check any skincare routine with a qualified healthcare professional.

Cetyloxypropyl Glyceryl Methoxypropyl Myristamide does not heighten sensitivity to sunlight and can be used both day and night without special precautions.

Potential Side Effects/Adverse Reactions

Individual responses to skincare ingredients vary. The points below describe uncommon yet possible reactions. When the ingredient is properly formulated most users will not experience any of these issues.

  • Mild redness or itching in people sensitive to fatty alcohols or amides
  • Temporary clogged pores in very oil-rich or acne-prone skin
  • Stinging if applied to broken or freshly exfoliated skin
  • Eye irritation if the product migrates into the eye area

If any discomfort or visible irritation occurs stop using the product and consult a skincare professional or doctor for guidance.

Comedogenic Rating

Rating: 2 out of 5. Cetyloxypropyl Glyceryl Methoxypropyl Myristamide is a large branched lipid that spreads thinly on the skin so it does not readily settle into pores the way heavier straight chain oils can. Formulas typically use it at low levels, further reducing the chance of congestion. Still, its fatty backbone gives it a mild occlusive nature, which is why the score is not a perfect zero. Most acne-prone users find it acceptable, though exceptionally reactive or very oily skin might prefer to avoid daily use. As with any emollient, the overall pore-clogging risk depends on the complete formula and how often it is applied.

Summary

Cetyloxypropyl Glyceryl Methoxypropyl Myristamide is a lab crafted emollient that conditions skin by forming a light breathable film and by slipping into microscopic gaps between surface cells. These actions soften rough patches, improve moisture retention and give creams, lotions and serums a velvety after feel.

It is a niche ingredient rather than a headline act, showing up mainly in mid to high end moisturizers where a cushiony texture is desired. Its popularity is growing as formulators look for elegant plant-derived alternatives to heavier oils.

Current safety data show it to be low risk for irritation, non sensitizing and vegan friendly. As with any new skincare ingredient it is wise to patch test a product on a small area first to confirm personal compatibility before full-face use.

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