What Is Chlorella Vulgaris Methionyl Sh-Polypeptide-14 Hexapeptide-40?
Chlorella Vulgaris Methionyl Sh-Polypeptide-14 Hexapeptide-40 is a lab crafted fusion protein produced by the freshwater microalga Chlorella vulgaris after the alga is given a small piece of human DNA that tells it how to build a skin compatible peptide. The finished chain holds 127 amino acids that line up in the same order our bodies use, starting with methionine. During production the peptide can form natural disulfide bridges or pick up tiny carbohydrate groups, both of which help it fold and stay stable.
The idea of asking algae to manufacture human style proteins took off in the early 2000s when cosmetic formulators wanted gentler bioactive ingredients that could be made sustainably. Chlorella grows fast in closed tanks, needs only light, water and minerals, and keeps contaminants low. By the mid-2010s suppliers were offering purified recombinant peptides from Chlorella for use in premium skin and hair care.
To make the ingredient, scientists insert or transiently express the gene that codes for Sh-Polypeptide-14 and Hexapeptide-40 into Chlorella cells. The algae are fermented, then harvested and broken open. The peptide is separated with filtration and chromatography, tested for purity, gently dried or kept in a concentrated solution then shipped to cosmetic labs.
You will most often see Chlorella Vulgaris Methionyl Sh-Polypeptide-14 Hexapeptide-40 in anti aging serums, firming creams, sheet masks, eye gels, soothing moisturizers, leave-on scalp tonics, lightweight conditioners, antioxidant boosters and astringent toners where it lends both performance and stability benefits.
Chlorella Vulgaris Methionyl Sh-Polypeptide-14 Hexapeptide-40’s Cosmetic Benefits/Uses
This multitasking peptide supports a formula in several ways
- Antimicrobial: Helps keep unwanted bacteria and fungi from multiplying on the skin and within the product itself which can reduce breakouts and extend shelf life
- Antioxidant: Neutralises free radicals generated by UV light and pollution helping to protect proteins lipids and DNA in the skin from premature aging
- Astringent: Provides a mild skin tightening effect that can temporarily minimise the look of enlarged pores and give a smoother surface feel
- Emulsion Stabilising: Improves the uniform distribution of oil and water phases so creams and lotions stay smooth and do not separate over time
- Hair Conditioning: Deposits a light protective film on strands that can enhance softness reduce static and make hair easier to comb
- Skin Protecting: Forms a breathable barrier that shields against environmental stressors and helps maintain moisture balance
Who Can Use Chlorella Vulgaris Methionyl Sh-Polypeptide-14 Hexapeptide-40
This peptide is generally considered suitable for all skin types, including balanced, dry, oily, combination and sensitive skin. Its lightweight film forming action helps hold moisture without leaving a heavy or greasy feel, so even acne-prone or easily congested skin typically tolerates it well. There are no known qualities that would make it inherently unsuitable for any particular skin type
The ingredient is produced by microalgae using a recombinant process that does not involve animals, so it is appropriate for vegans and vegetarians
Current data suggest no specific risks for pregnant or breastfeeding women when the peptide is used topically in cosmetic concentrations. Still, this information is educational only, not medical advice. Anyone who is expecting or nursing should check with a qualified healthcare professional before adding new skincare products
Chlorella Vulgaris Methionyl Sh-Polypeptide-14 Hexapeptide-40 is not known to cause photosensitivity, so it does not make skin more reactive to sunlight. Standard daily sunscreen use is still recommended for overall skin health
The peptide has a neutral scent, is fragrance free by nature and is compatible with most other common skincare ingredients
Potential Side Effects/Adverse Reactions
Reactions to topical Chlorella Vulgaris Methionyl Sh-Polypeptide-14 Hexapeptide-40 vary from person to person. The points below outline potential side effects, though most users will not encounter them when the ingredient is formulated and used correctly
- Mild transient redness or warmth immediately after application
- Localized itching or tingling, especially on very reactive skin
- Dry or tight feeling if layered with multiple astringent products
- Rare cases of allergic contact dermatitis linked to individual peptide sensitivity
- Eye irritation if the product inadvertently gets into the eyes
- Interaction with highly acidic formulas that could destabilize the peptide and reduce its effectiveness
If any of these effects occur discontinue use and consult a healthcare professional or dermatologist for guidance
Comedogenic Rating
Rating: 0 (non-comedogenic)
Chlorella Vulgaris Methionyl Sh-Polypeptide-14 Hexapeptide-40 is a large water soluble peptide with no oily or waxy residues so it does not clog pores or trap sebum inside follicles. Its lightweight film forms a breathable layer that lets skin surface lipids escape normally which keeps pore blockage risk very low.
Suitable for acne-prone and breakout-prone skin.
As with any ingredient overall comedogenicity depends on the finished formula so the rating refers to the peptide itself not the full product.
Summary
This recombinant algae-derived peptide acts as an antimicrobial antioxidant astringent emulsion stabiliser hair conditioner and skin protectant. It does so by carrying a precise chain of 127 amino acids that can bind water, chelate metals, scavenge free radicals and form a thin cohesive film on skin or hair all while supporting formula stability.
Although still a niche ingredient compared to classic peptides it is gaining attention in premium serums and lightweight conditioners thanks to sustainable microalgae sourcing and its multitasking profile.
Current data show a strong safety record with low irritation potential and no comedogenicity. Even so anyone introducing a new product that contains this peptide should perform a simple patch test to confirm personal tolerance.