Citrobacter/Soy Protein Ferment: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 24, 2025
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All information on this page is verified using The Personal Care Products Council's (PCPC) INCI database. Our ingredient analyses are based exclusively on PCPC's technical data to ensure accuracy and reliability.

What Is Citrobacter/Soy Protein Ferment?

Citrobacter/Soy Protein Ferment is an active made by letting the friendly microbe Citrobacter feed on soy protein in a controlled setting. During this process the bacteria break down large soy molecules into smaller fragments called peptides and amino acids. These lightweight pieces are easier for skin to absorb and help boost the product’s feel and performance. The idea of using fermented plant proteins in beauty care grew popular in the past two decades, following research that showed fermentation can unlock extra skin benefits from everyday foods. To create the ingredient, purified soy protein is mixed with water, nutrients and a starter culture of Citrobacter. The mixture sits in warm tanks until the desired level of breakdown is reached, then it is filtered, pasteurized and dried into a stable liquid or powder. You will most often see Citrobacter/Soy Protein Ferment in hydrating serums, anti-aging creams, sheet masks, soothing lotions and leave-on treatments where a gentle conditioning boost is welcome.

Citrobacter/Soy Protein Ferment’s Cosmetic Benefits/Uses

Its main role in skin care is skin conditioning. By supplying skin-friendly peptides and amino acids, it helps keep the surface smooth, soft and comfortably hydrated. Products that include this ferment often claim a more supple feel, improved texture and better moisture retention with regular use.

Who Can Use Citrobacter/Soy Protein Ferment

This ferment suits most skin types, from dry to oily and even sensitive, because its peptides and amino acids are lightweight and non-greasy. People with very reactive or soy-allergic skin should proceed with caution since the source material is soy protein, though the fermentation step usually makes it less likely to trigger issues.

The ingredient is plant derived and created through microbial fermentation, so it is considered vegan and vegetarian friendly with no animal by-products involved.

No specific warnings exist for pregnant or breastfeeding women when it is used topically at the small levels found in cosmetics. That said this is not medical advice and anyone who is expecting or nursing should clear any new skincare product with a healthcare professional first.

Citrobacter/Soy Protein Ferment is not known to cause photosensitivity, so it can be used in day or night routines without raising the skin’s sensitivity to sunlight.

Potential Side Effects/Adverse Reactions

Responses to topical Citrobacter/Soy Protein Ferment differ from person to person. The effects listed below are only potential outcomes and are unlikely for the average user when the ingredient is formulated correctly.

  • Allergic reaction – rare itching, redness or hives in individuals sensitive to soy or fermentation by-products
  • Minor irritation – a temporary stinging or warm feeling, most often in very sensitive skin when first applied
  • Contact dermatitis – exceptionally uncommon rash or swelling if one is specifically allergic to a preservative or other formula component rather than the ferment itself

If irritation or any adverse effect appears stop using the product and consult a dermatologist or healthcare provider.

Comedogenic Rating

Rating: 1/5 – Citrobacter/Soy Protein Ferment is made up mostly of water-soluble peptides and amino acids that do not sit heavily on skin or block pores. The fermentation process further reduces the size of the molecules, lowering the chance they will build up inside follicles. For these reasons it earns a very low comedogenic score.

Suitable for acne-prone skin, as its lightweight nature is unlikely to trigger breakouts.

Formula texture and accompanying ingredients matter more than the ferment itself, so always look at the full ingredient list when judging pore-clogging potential.

Summary

Citrobacter/Soy Protein Ferment is used mainly for skin conditioning, helping skin feel softer, smoother and better hydrated. It does this by delivering small peptides and amino acids produced during controlled fermentation, which skin can easily absorb and use to support its barrier.

The ingredient remains something of a niche find compared with big names like hyaluronic acid or niacinamide, yet formulators value it for adding a gentle, plant-based boost to serums, creams and masks.

Topical use is generally considered safe, with very low risk of irritation or pore blockage when used at cosmetic levels. As with any new skincare product, patch testing first is a smart extra step.

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