Cocodimonium Hydroxypropyl Hydrolyzed Collagen: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 24, 2025
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All information on this page is verified using The Personal Care Products Council's (PCPC) INCI database. Our ingredient analyses are based exclusively on PCPC's technical data to ensure accuracy and reliability.

What Is Cocodimonium Hydroxypropyl Hydrolyzed Collagen?

Cocodimonium Hydroxypropyl Hydrolyzed Collagen is a modified form of collagen, the structural protein best known for giving skin and hair their strength and elasticity. In this case the collagen has been broken down into smaller peptides (hydrolyzed) then further reacted with coconut-derived fatty chains and quaternized to create a water-soluble chloride salt. This combination of protein fragments and positively charged lipids lets the ingredient cling to negatively charged surfaces like damaged hair or rough skin.

The ingredient emerged in the late 20th century when formulators began searching for milder, more sustainable conditioning agents than traditional animal-based tallow derivatives. By linking hydrolyzed collagen to coconut-based amines they created a molecule that offered the feel of protein with the smooth glide of a conditioner. Today it is produced by first hydrolyzing collagen, usually from fish or bovine sources, into small peptides. These peptides are then reacted with epichlorohydrin and a coconut fatty amine before quaternization, yielding the final cationic polymer that disperses easily in water-based formulations.

You will typically find Cocodimonium Hydroxypropyl Hydrolyzed Collagen in rinse-off and leave-on hair conditioners, shampoos, hair masks, styling creams, facial moisturizers, anti-aging serums, sheet masks and lightweight body lotions where a silky finish is desired.

Cocodimonium Hydroxypropyl Hydrolyzed Collagen’s Cosmetic Benefits/Uses

This multi-tasking ingredient brings several helpful properties to both hair and skin care formulas

  • Antistatic: The positive charge neutralizes static electricity on hair strands, cutting down on flyaways and helping styles stay smooth even in dry or low-humidity environments
  • Hair Conditioning: The small collagen peptides form a thin, flexible film on the hair shaft, boosting softness, slip and shine while the coconut-derived tail adds extra lubrication for easier detangling
  • Skin Conditioning: On skin the protein fragments bind water and lightly tighten the surface, giving a temporarily smoother feel and a soft, hydrated finish without heaviness

Who Can Use Cocodimonium Hydroxypropyl Hydrolyzed Collagen

Cocodimonium Hydroxypropyl Hydrolyzed Collagen is generally gentle enough for all skin types including dry, oily, sensitive and mature skin because its film-forming action is lightweight and non-greasy. Those with very reactive skin should still introduce any new product slowly in case fragrance or other formula components cause issues.

The collagen used to create this ingredient is typically sourced from fish or bovine by-products, which makes it unsuitable for vegans or strict vegetarians. Anyone following a plant-based lifestyle may wish to look for formulas that use vegetable proteins or lab-grown “collagen alternatives” instead.

No specific concerns have been raised for pregnant or breastfeeding women when Cocodimonium Hydroxypropyl Hydrolyzed Collagen is applied topically in cosmetic amounts. This is not medical advice and expecting or nursing mothers should check with their healthcare provider before adding any new personal care product, just to be safe.

The ingredient does not make skin more sensitive to sunlight, so it is not considered photosensitizing. It also plays well with most other common actives such as niacinamide, peptides and silicones, making it easy to slot into an existing routine.

Potential Side Effects/Adverse Reactions

Reactions to topical Cocodimonium Hydroxypropyl Hydrolyzed Collagen can differ from one person to another. The points below list potential side effects that have been reported, but they are uncommon and most users will not experience them when using a well-formulated product.

  • Mild skin redness or itching
  • Contact dermatitis in individuals allergic to animal proteins or quaternary ammonium compounds
  • Eye stinging or watering if the product accidentally gets into the eyes
  • Hair limpness or buildup when overused in leave-in conditioners

If any irritation or other negative reaction occurs stop using the product and consult a healthcare professional or dermatologist.

Comedogenic Rating

Rating: 1 / 5 (low)

Cocodimonium Hydroxypropyl Hydrolyzed Collagen is water soluble and forms a lightweight film that rinses off easily. Although it contains a coconut-derived fatty tail, the molecule is positively charged and stays mostly on the surface, so it is far less likely to block pores than straight oils or butters. Most dermatology references place quaternized proteins in the low to very low clogging range.

Because of this low rating the ingredient is generally considered suitable for people who are prone to acne or breakouts.

Keep in mind a formula’s overall comedogenicity depends on every ingredient present, so a product with this collagen derivative could still cause congestion if it also contains heavier occlusives.

Summary

Cocodimonium Hydroxypropyl Hydrolyzed Collagen works as an antistatic agent, hair conditioner and skin conditioner. The positive charge lets it magnetically attach to damaged hair cuticles and rough skin, while the small collagen peptides create a flexible moisture-holding film that smooths, softens and adds a hint of shine.

It enjoys moderate popularity, showing up most often in mid-range and salon hair care lines plus a handful of moisturizing serums and masks. It is not as ubiquitous as silicone conditioners or plain hydrolyzed proteins, but formulators like it when they want a protein-rich feel without heaviness.

Topically it is viewed as very safe with a low risk of irritation or pore clogging for most users. As with any new cosmetic ingredient it is smart to do a quick patch test when trying a fresh product that contains it just to be on the safe side.

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