Cocodimonium Hydroxypropyl Hydrolyzed Hair Keratin: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 24, 2025
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All information on this page is verified using publicly available nomenclature standards and reference materials from The Personal Care Products Council (PCPC) and the European Commission's CosIng database. Our analyses are based on technical data from these sources to ensure accuracy and reliability.

What Is Cocodimonium Hydroxypropyl Hydrolyzed Hair Keratin?

Cocodimonium Hydroxypropyl Hydrolyzed Hair Keratin is a water-soluble form of keratin protein that has been chemically modified into a quaternary ammonium chloride. The starting material is usually keratin sourced from wool or human hair collected during salon cutting. This raw keratin is broken down into smaller fragments through a process called hydrolysis so it can dissolve in water and penetrate hair and skin more easily. The hydrolyzed protein is then reacted with propylene oxide to add hydroxypropyl groups that improve flexibility and moisture attraction. Finally the material is quaternized with a coconut-derived fatty amine, giving it a positive charge that helps it bind to negatively charged hair and skin surfaces.

Keratin has been studied for cosmetic use since the 1950s, but early forms rinsed away quickly. Quaternized versions like Cocodimonium Hydroxypropyl Hydrolyzed Hair Keratin gained popularity in the late 1990s because they stick to hair fibers far better, providing longer-lasting conditioning. Today formulators favor this ingredient for its balance of strength building, softness and antistatic control.

You will most often find Cocodimonium Hydroxypropyl Hydrolyzed Hair Keratin in rinse-off and leave-in hair conditioners, repair masks, anti frizz sprays, color protection treatments, styling creams, skin lotions and hand creams that aim to boost softness and smoothness.

Cocodimonium Hydroxypropyl Hydrolyzed Hair Keratin’s Cosmetic Benefits/Uses

This multifunctional protein derivative supports both hair care and skin care formulas in several ways:

  • Antistatic: Its positive charge neutralizes the negative charges that build up on hair strands during brushing and drying which helps reduce flyaways and static cling for a sleeker finish
  • Hair conditioning: The small keratin peptides deposit onto damaged areas of the cuticle, filling in rough spots, improving strength, adding shine and making hair feel softer and easier to detangle
  • Skin conditioning: On skin it forms a light breathable film that helps hold moisture, leaving the surface feeling smooth and supple without greasiness

Who Can Use Cocodimonium Hydroxypropyl Hydrolyzed Hair Keratin

This ingredient is generally well tolerated by all skin and hair types. Its lightweight film forming action suits dry skin that needs extra moisture, yet it is non greasy enough for combination or oily skin. Most sensitive users can also use it comfortably because it has a mild conditioning profile, though anyone with a known allergy to wool or animal proteins should be cautious.

Cocodimonium Hydroxypropyl Hydrolyzed Hair Keratin is produced from animal keratin sourced from wool or salon collected human hair, so it is not considered vegan friendly. Some vegetarians may accept human hair derived keratin while others may prefer to avoid any animal sourced material altogether. Shoppers looking for plant based alternatives should verify the supply chain or choose a botanical protein instead.

Current safety data shows no evidence that topical use poses a risk to people who are pregnant or breastfeeding. The large protein fragments stay on the skin and hair surface rather than entering the bloodstream. That said this information is not medical advice and pregnant or nursing individuals should discuss any new cosmetic product with their healthcare provider just to be sure.

Cocodimonium Hydroxypropyl Hydrolyzed Hair Keratin does not increase photosensitivity so it will not make skin more prone to sunburn. It also plays well with the vast majority of other cosmetic ingredients and does not interfere with common actives like retinol or vitamin C.

Potential Side Effects/Adverse Reactions

Side effects from topical Cocodimonium Hydroxypropyl Hydrolyzed Hair Keratin vary from person to person. The following list covers potential reactions yet most users will not experience them when the ingredient is formulated correctly.

  • Allergic contact dermatitis resulting in redness, itching and rash
  • Mild stinging or irritation on very sensitive scalps or skin
  • Eye irritation if the product accidentally gets into the eyes
  • Product buildup that can leave hair feeling heavy or greasy when used in excess

If you notice any uncomfortable reaction discontinue use immediately and consult a medical professional for guidance.

Comedogenic Rating

Rating: 0–1 (very low)

Cocodimonium Hydroxypropyl Hydrolyzed Hair Keratin is a water-soluble protein derivative with no oily or waxy residues that could clog pores. It rinses away easily from skin and hair, so it rarely lingers long enough to block follicles. Because of this the ingredient is considered suitable for people who are prone to acne or breakouts.

Since most formulas use it at modest levels for slip and conditioning, there is little chance of it stacking up in pores unless the product itself is overly heavy or not thoroughly removed. Users who layer multiple rich products should be aware that buildup from other components, not the keratin derivative, could still trigger congestion.

Summary

Cocodimonium Hydroxypropyl Hydrolyzed Hair Keratin is a quaternized hydrolyzed keratin that conditions hair, tames static and leaves a light moisture film on skin. Its positive charge helps it cling to damaged hair cuticles and skin surfaces, while the small protein fragments fill in rough spots for added smoothness and strength.

Although not as famous as silicones or classic plant oils, this ingredient has carved out a steady niche in modern conditioners, masks and leave-ins because it offers noticeable softness without weight. Skin care brands also tap it for non-greasy hydration.

Current research and decades of cosmetic use show it to be low risk for most users. Serious reactions are rare, but as with any new product it is wise to run a small patch test first to confirm personal compatibility.

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