Cocodimonium Hydroxypropyl Hydrolyzed Keratin: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 24, 2025
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All information on this page is verified using The Personal Care Products Council's (PCPC) INCI database. Our ingredient analyses are based exclusively on PCPC's technical data to ensure accuracy and reliability.

What Is Cocodimonium Hydroxypropyl Hydrolyzed Keratin?

Cocodimonium Hydroxypropyl Hydrolyzed Keratin is a keratin protein that has been broken down into smaller pieces then linked to a quaternized coconut-derived compound. The result is a water-soluble ingredient that carries a gentle positive charge, helping it cling to hair or skin surfaces. It began making its way into beauty formulas in the late 1990s when chemists looked for new ways to deliver the strength of keratin without the heavy feel of traditional proteins.

The process starts with keratin from sources like sheep wool which is hydrolyzed, meaning it is cut into tiny peptides. These peptides are reacted with a coconut fatty amine plus propylene oxide, creating the “hydroxypropyl” bridge that gives the ingredient its conditioning charge. The final step adds chloride to balance the charge and keep the material stable in water-based products.

You will most often spot Cocodimonium Hydroxypropyl Hydrolyzed Keratin in rinse-off and leave-in hair masks, shampoos, conditioners, color-protecting treatments, smoothing serums and styling creams. Some skin care brands also add it to moisturizing lotions and hand creams to support a soft feel.

Cocodimonium Hydroxypropyl Hydrolyzed Keratin’s Cosmetic Benefits/Uses

This multi-tasking ingredient improves both the look and feel of hair and skin.

  • Antistatic – Its positive charge counteracts static electricity so hair is less likely to fly away or cling to clothing
  • Hair Conditioning – The small keratin fragments latch onto damaged spots along the cuticle, smoothing rough edges, boosting shine and making strands easier to detangle
  • Skin Conditioning – On skin it forms a light film that helps hold moisture, leaving the surface soft and supple

Who Can Use Cocodimonium Hydroxypropyl Hydrolyzed Keratin

This lightweight keratin derivative is generally well tolerated by all skin and hair types, including oily, dry, combination and sensitive. Because it is water soluble and lightly conditioning it rarely leaves a greasy residue that could trouble acne-prone complexions. People with very fine or low-porosity hair may find that overuse can weigh strands down so lighter formulas or occasional use are recommended.

The ingredient is sourced from animal keratin, most commonly sheep wool, so it is not suitable for strict vegans. Vegetarians who are comfortable with wool-derived materials may still choose to use products containing it.

No studies suggest that Cocodimonium Hydroxypropyl Hydrolyzed Keratin poses a specific risk to women who are pregnant or breastfeeding. That said this is not medical advice and anyone who is expecting or nursing should show the ingredient list to a qualified healthcare provider before adding new products to their routine.

The molecule does not increase photosensitivity, so it will not make skin more prone to sunburn. It is also compatible with most common hair dyes, styling polymers and skincare actives, which makes it easy to slot into existing regimens.

Potential Side Effects/Adverse Reactions

Side effects from topical use of Cocodimonium Hydroxypropyl Hydrolyzed Keratin vary from person to person. The following issues are possible yet unlikely when the ingredient is used at typical levels in well-formulated products

  • Allergic contact dermatitis – rare cases of redness itching or rash due to sensitivity to keratin peptides or the quaternary ammonium group
  • Scalp or skin irritation – a tingling or burning sensation if the formula is left on too long or used on already compromised skin
  • Product buildup – heavy or frequent application can leave fine hair looking flat or coated
  • Eye irritation – stinging or watering if shampoo or mask accidentally gets into the eyes
  • Interaction with other cationic ingredients – layering multiple strongly charged conditioners may lead to a gummy feel on hair

If any discomfort or reaction occurs stop using the product immediately and seek advice from a healthcare professional

Comedogenic Rating

Rating: 1 / 5
Cocodimonium Hydroxypropyl Hydrolyzed Keratin is water soluble and does not contain heavy oils or waxes that commonly clog pores. Its small, positively charged protein pieces rinse away easily and tend to sit on the surface rather than seep into sebaceous follicles, so it earns a low score of 1. This makes it generally suitable for people who are prone to acne or breakouts. The only caveat is that formulas pairing it with richer butters or occlusive silicones could still trigger congestion for some users.

Summary

Cocodimonium Hydroxypropyl Hydrolyzed Keratin acts as an antistatic agent, hair conditioner and skin conditioner. Its hydrolyzed keratin fragments seek out damaged areas where their positive charge helps them bond, smoothing rough cuticles on hair and forming a light moisture-holding film on skin. The coconut-derived quaternary portion keeps the ingredient water friendly so it distributes evenly and rinses clean.

While not as mainstream as ingredients like argan oil or panthenol, it shows up frequently in mid to premium hair care lines and occasionally in skin lotions that aim for a silky afterfeel. Its safety record is strong with only rare reports of irritation or allergy.

Most people can use products containing Cocodimonium Hydroxypropyl Hydrolyzed Keratin without worry, yet it is always wise to patch test any new formula to make sure it agrees with your individual skin or scalp.

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