Cyanomethylphenyl Menthane Carboxamide: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 24, 2025
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All information on this page is verified using The Personal Care Products Council's (PCPC) INCI database. Our ingredient analyses are based exclusively on PCPC's technical data to ensure accuracy and reliability.

What Is Cyanomethylphenyl Menthane Carboxamide?

Cyanomethylphenyl Menthane Carboxamide is a lab made compound belonging to the carboxamide family of ingredients. Its chemical structure is based on a cyclohexane ring that carries both a menthane group and a cyanomethyl phenyl group, giving it stability and a mild mint like profile. Because it is synthetic, manufacturers can control purity and quality from batch to batch.

The ingredient was first explored in the late 1990s when formulators searched for new cooling agents that could refresh the mouth without the strong bite of traditional menthol. Over time it moved from flavor research into the cosmetic world, especially in products aimed at oral freshness.

Production starts with menthane derived from peppermint oil. Chemists modify the menthane backbone by adding a carboxamide link then attach a cyanomethyl phenyl side chain. Careful temperature control and purification steps remove unwanted byproducts, leaving a white crystalline powder that dissolves easily in cosmetic bases.

You will most often find Cyanomethylphenyl Menthane Carboxamide in toothpaste, mouth rinse, breath sprays and flavored dental gels. Some lip care balms and sugar free chewing gums designed to freshen breath also use it, though its main home remains oral care lines.

Cyanomethylphenyl Menthane Carboxamide’s Cosmetic Benefits/Uses

This ingredient is prized for how it supports products meant to clean and freshen the mouth.

Oral care: Cyanomethylphenyl Menthane Carboxamide delivers a long lasting cooling sensation that masks unpleasant tastes and leaves the mouth feeling fresh. Because it is less intense than menthol it reduces the risk of stinging or irritation, making toothpaste or mouthwash more comfortable for people with sensitive gums. Its stable structure also means the cooling effect stays consistent throughout the shelf life of the product, helping formulators rely on its performance without needing high levels that could cause dryness.

Who Can Use Cyanomethylphenyl Menthane Carboxamide

Because the ingredient is mainly used inside the mouth and not on facial skin it is considered suitable for every skin type including dry, oily and sensitive. Its cooling action is gentler than menthol so users prone to stinging or redness usually tolerate it well.

Cyanomethylphenyl Menthane Carboxamide is made entirely from synthetic building blocks and contains no material sourced from animals. That makes it appropriate for both vegans and vegetarians.

No data suggest that the molecule is absorbed into the bloodstream in any meaningful amount when used in toothpaste or mouthwash. Still, anyone who is pregnant or breastfeeding should check with a doctor before adding new personal care products just to be safe since this is not medical advice.

The ingredient does not heighten photosensitivity and there are no special sun care precautions associated with it. It is also free of common allergens like gluten or soy so cross reactions with those sensitivities are unlikely.

Potential Side Effects/Adverse Reactions

  • Mild tingling or cooling that feels uncomfortable for a few minutes
  • Transient oral irritation in people with very sensitive gums
  • Allergic contact dermatitis on the lips or skin around the mouth
  • Excess salivation or temporary change in taste perception
  • Rare headache or lightheadedness if a large amount is swallowed

If any negative effect occurs stop using the product and seek advice from a healthcare professional.

Comedogenic Rating

Rating: 0 / 5

Cyanomethylphenyl Menthane Carboxamide is a lightweight crystalline powder that is neither oily nor waxy and is used at very low levels in rinse off oral care formulas. It does not sit on facial skin or form a film that could block pores, so the chance of it causing blackheads or breakouts is practically zero.

This makes it perfectly fine for people who struggle with acne or frequent blemishes.

Because most products containing it are spit out or rinsed away, skin exposure is minimal which further reduces any pore clogging risk.

Summary

Cyanomethylphenyl Menthane Carboxamide is a lab made cooling agent that freshens the mouth, masks bad tastes and gives toothpastes and mouthwashes a gentle mint like feel without the bite of straight menthol. Its stable structure keeps the chill effect consistent throughout a product’s shelf life and its synthetic origin allows tight control over purity.

While not a household name, it is gaining steady traction in premium oral care lines that want a smooth long lasting cool sensation. You will see it pop up in some lip balms and breath sprays but it remains a niche player compared with classic menthol.

Current data show it to be very safe when used as directed with only rare reports of mild irritation or taste changes. As with any new personal care ingredient it is smart to patch test a small area before full use just to be cautious.

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