What Is Cyclotetrapeptide-24 Aminocyclohexane Carboxylate?
Cyclotetrapeptide-24 Aminocyclohexane Carboxylate is a lab-designed peptide made of four amino acids arranged in a ring that is capped with an aminocyclohexane carboxylate group. This ring structure helps the molecule stay stable on the skin and do its job effectively. The ingredient was first explored in advanced skincare research focused on mimicking the skin’s own repair signals. Over time formulators noticed that its antioxidant ability could support smoother brighter-looking skin, leading to its adoption in premium cosmetic lines during the early 2010s.
The peptide is produced through solid-phase peptide synthesis, a step-by-step process that links protected amino acids in a precise order. After the chain is built it is chemically “cyclized” to form a closed ring, then purified to cosmetic grade. Because everything happens in a controlled lab setting the final ingredient is both consistent and free from animal-derived impurities.
You will most often see Cyclotetrapeptide-24 Aminocyclohexane Carboxylate in anti-aging serums, firming creams, sheet masks and targeted treatments that promise improved skin tone or texture. Brands add it to moisturizers and eye creams as well, pairing it with hydrators and soothing agents for a rounded formula.
Cyclotetrapeptide-24 Aminocyclohexane Carboxylate’s Cosmetic Benefits/Uses
Formulators choose this peptide for its ability to protect and support the skin at a cellular level.
As an antioxidant Cyclotetrapeptide-24 Aminocyclohexane Carboxylate helps neutralize free radicals generated by UV light and pollution, which can contribute to fine lines dullness and loss of firmness. By reducing this daily oxidative stress the peptide helps maintain a healthier-looking complexion and can boost the overall stability of the product itself, preserving color and scent for a longer shelf life.
Who Can Use Cyclotetrapeptide-24 Aminocyclohexane Carboxylate
This peptide is generally well tolerated by all major skin types including dry oily combination and sensitive because it has a small molecular size and a neutral pH that does not disturb the skin barrier. Extremely reactive or allergy-prone skin may still prefer to introduce the ingredient slowly to confirm comfort.
Cyclotetrapeptide-24 Aminocyclohexane Carboxylate is made entirely in a lab with no animal-derived starting materials, so it is suitable for vegans and vegetarians.
No specific warnings exist for pregnant or breastfeeding women, and the ingredient is not known to penetrate deeply or interfere with hormones. That said this is not medical advice and anyone who is pregnant or nursing should check with a healthcare professional before adding new skincare products.
The peptide does not cause photosensitivity, so it can be used morning or night. Standard daytime sun protection is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Side effects from topical Cyclotetrapeptide-24 Aminocyclohexane Carboxylate vary from person to person. The points below list potential reactions that could occur even though most users experience none of them when the ingredient is formulated and used correctly.
- Mild redness or warmth at the application site
- Temporary itching or tingling
- Dry patches if the formula lacks adequate hydrators
- Rare allergic contact dermatitis leading to swelling or hives
- Eye irritation if the product is accidentally rubbed into the eye area
If any of these effects develop stop using the product and consult a healthcare professional if symptoms persist or worsen.
Comedogenic Rating
Rating: 0/5. Cyclotetrapeptide-24 Aminocyclohexane Carboxylate is a small water soluble peptide that does not leave an oily or occlusive residue on the skin, so it lacks the ability to clog pores. In finished products it is usually present at low concentrations within lightweight serums or emulsions, further reducing any risk of congestion. This makes the ingredient suitable for people who are prone to acne or frequent breakouts. Because the peptide is not a fatty alcohol, oil, butter or wax, its comedogenic potential remains minimal even when combined with richer textures.
Summary
Cyclotetrapeptide-24 Aminocyclohexane Carboxylate acts mainly as an antioxidant, scavenging free radicals produced by UV exposure and pollution. Its cyclic structure keeps the molecule stable on the skin so it can keep working while also helping protect the overall formula from oxidation. By lowering oxidative stress the peptide supports a smoother brighter complexion and can complement other age support ingredients such as hydrators or barrier lipids.
Although effective the peptide is still a niche addition found mostly in higher end serums eye creams and masks rather than in mass market skincare. As awareness of short chain peptides grows more brands may decide to include it for its protective benefits and pleasant texture profile.
Current safety data and user feedback show the ingredient is well tolerated across skin types with very low risk of sensitization or pore blockage. Even so it is always smart to do a quick patch test whenever you start using a new product to confirm personal compatibility.