Dechloro Cyclopropylmethylcloprostenolamide: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Dechloro Cyclopropylmethylcloprostenolamide?

Dechloro Cyclopropylmethylcloprostenolamide is a lab-made molecule belonging to the prostaglandin family, a group of fatty compounds that can offer protective effects for skin. Chemists removed chlorine from an earlier prostaglandin structure and added a small cyclopropylmethyl group, giving the ingredient greater stability and a friendlier safety profile for topical use. The full chemical name, 5-Heptenamide N-(cyclopropylmethyl)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-phenoxy-1-buten-1-yl]cyclopentyl]- (5Z), hints at several hydroxyl groups that help it blend well with water-based or mixed formulations while the fatty backbone lets it anchor into creams and serums.

This ingredient first appeared in specialty lash and brow products where its antioxidant nature helped preserve delicate hairs. As formulators noticed its skin-friendly profile they began testing it in anti-aging creams and overnight masks. Today it is produced through a multi-step organic synthesis that starts with plant-derived fatty acids. These acids are converted into the cyclopentyl core, functional groups are added in controlled steps, then the final amide bond is formed and the product is purified to cosmetic grade.

You will most often see Dechloro Cyclopropylmethylcloprostenolamide in lightweight serums, revitalizing eye creams, rich night moisturizers and sheet masks aimed at tired or environmentally stressed skin. Because it tackles oxidative stress it is also blended into leave-on treatments that promise a smoother brighter look.

Dechloro Cyclopropylmethylcloprostenolamide’s Cosmetic Benefits/Uses

In skincare formulas this ingredient serves one key purpose that delivers noticeable results for the user.

Antioxidant activity helps neutralize free radicals created by UV light, pollution and daily stress. By limiting this damage the ingredient supports a more even tone and can slow the look of fine lines caused by oxidative stress. It also helps keep the overall formula stable so the product stays effective for longer on your shelf.

Who Can Use Dechloro Cyclopropylmethylcloprostenolamide

Thanks to its lightweight texture and low irritation profile Dechloro Cyclopropylmethylcloprostenolamide suits most skin types. Normal, dry and combination skin tend to enjoy its subtle moisturizing feel while oily or acne-prone users appreciate that it is non-pore-clogging. Even sensitive skin generally tolerates it since it lacks strong acids or fragrances that can trigger flare-ups.

The molecule is produced entirely through synthetic steps that start with plant-derived fatty acids and contain no animal by-products, making it appropriate for vegans and vegetarians.

Because the ingredient is a prostaglandin analogue, pregnant or breastfeeding women should exercise extra caution. Absorption from topical use is believed to be very low yet clinical data remain limited. This is not medical advice, so anyone who is expecting or nursing should ask a healthcare professional before adding products with Dechloro Cyclopropylmethylcloprostenolamide to their routine.

The ingredient does not make skin more sensitive to sunlight and actually helps protect against UV-generated free radicals. Standard daytime protection with a broad-spectrum sunscreen is still recommended for overall skin health.

Potential Side Effects/Adverse Reactions

Reactions to topical Dechloro Cyclopropylmethylcloprostenolamide differ from person to person. The effects listed below are possible yet uncommon when the ingredient is formulated and used correctly.

  • Mild redness or warmth at the application site
  • Temporary itching or tingling
  • Rare allergic contact dermatitis presenting as a rash
  • Slight darkening or thickening of fine hairs where the product is applied, more noticeable on brows and lash lines
  • Increased sensitivity if layered with strong exfoliating acids or retinoids

If you notice any unexpected discomfort or changes while using a product containing this ingredient stop application and seek advice from a qualified healthcare professional.

Comedogenic Rating

Rating: 1 (very low likelihood of clogging pores)

Dechloro Cyclopropylmethylcloprostenolamide is a small prostaglandin-type molecule that delivers antioxidant help without relying on heavy oils or waxes. It sits light on the skin, absorbs quickly and does not leave an occlusive film, which keeps the risk of trapped sebum minimal. A rating of 1 means most users, even those prone to congestion, should not notice blocked pores.

Because the ingredient is usually present at low percentages and is paired with light emulsifiers it remains a safe pick for acne-prone or breakout-prone skin.

No evidence suggests that it worsens blackheads or whiteheads, but a formula’s overall composition still matters, so pair it with non-comedogenic bases for best results.

Summary

Dechloro Cyclopropylmethylcloprostenolamide is an antioxidant ingredient that helps mop up free radicals created by UV exposure and pollution. By neutralizing these unstable molecules it supports a smoother more even complexion and protects other actives in a formula from breaking down.

Outside niche lash and brow enhancers its use in mainstream skincare remains modest, though it is slowly appearing in modern serums and overnight masks that chase gentle yet effective antioxidant support.

Current data show a low irritation profile and very low comedogenicity, making it safe for most skin types. Still, everyone’s skin responds differently, so perform a small patch test when trying any new product containing this ingredient to confirm personal tolerance.

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