What Is Dechloro Ethylcloprostenolamide?
Dechloro Ethylcloprostenolamide is a lab-created molecule belonging to the prostaglandin family, a group of fat-derived compounds that naturally occur in the body. Chemically it is known as 7-[3,5-Dihydroxy-2-(3-Hydroxy-4-Phenoxy-But-1-Enyl)-Cyclopentyl-5Z-Heptenoic Acid Ethylamide, a name that reflects its multi-ring structure and several hydroxyl groups that help it interact with hair fibers. Scientists first explored analogs of prostaglandins in the early 2000s while researching ways to support fuller eyelashes and brows. Removing chlorine atoms and attaching an ethylamide side chain produced a stable compound suited for cosmetic use, which led formulators to adopt it for over-the-counter hair products.
The ingredient is synthesized through a controlled multi-step process that starts with cyclopentane derivatives. These building blocks undergo selective hydroxylation, chain elongation, and phenoxy substitution before the final ethylamide group is added. Each stage is carried out in closed reactors followed by purification to ensure cosmetic-grade purity.
Because Dechloro Ethylcloprostenolamide targets hair appearance and feel, it is most often found in leave-on brow and lash serums, scalp tonics, specialty conditioners, and targeted hair-density boosters. You will rarely see it in basic shampoos or rinse-off products, as longer contact time enhances its performance.
Dechloro Ethylcloprostenolamide’s Cosmetic Benefits/Uses
This ingredient is prized for its ability to improve how hair looks and behaves on a daily basis.
Dechloro Ethylcloprostenolamide functions as a hair conditioning agent, meaning it helps soften strands, reduce breakage, and give hair a fuller healthier appearance. In brow or lash formulations it can make hairs appear thicker and more lustrous while enhancing flexibility so they resist snapping during brushing or makeup removal. On the scalp it supports a smoother cuticle surface, which translates to better light reflection and a natural shine.
Who Can Use Dechloro Ethylcloprostenolamide
This ingredient is generally considered suitable for all skin types, including oily, dry, combination and balanced skin. People with very sensitive or reactive skin should proceed cautiously because prostaglandin analogs can occasionally trigger irritation in those with a compromised skin barrier.
Dechloro Ethylcloprostenolamide is produced through a fully synthetic process, so it is not sourced from animals. Most formulations that feature it can be labeled vegan and vegetarian friendly as long as the finished product avoids animal-derived additives and the brand adheres to cruelty-free testing policies.
Limited data exist on topical use during pregnancy or while nursing. Although systemic absorption is expected to be low, prostaglandin analogs are pharmacologically active so anyone who is pregnant or breastfeeding should seek personalized guidance from a healthcare professional before adding products with this ingredient. This content is for informational purposes only and is not medical advice.
The molecule does not increase photosensitivity, so it will not make skin or scalp more vulnerable to sun damage. Normal sun protection habits still apply when using any cosmetic product.
Potential Side Effects/Adverse Reactions
Responses to topical Dechloro Ethylcloprostenolamide vary by individual. The following list covers potential side effects that have been reported with prostaglandin-based ingredients, yet most users who apply a well-formulated product will not experience them.
- Localized redness or mild stinging
- Itching of the application site
- Dryness or flaking of the eyelid or scalp
- Darkening of the skin where the product is applied
- Increased pigmentation of the iris when used near the eyes
- Unwanted hair growth on areas that come into repeated contact with residue
- Allergic contact dermatitis
If you notice any of the above reactions stop using the product and consult a qualified healthcare professional.
Comedogenic Rating
Rating: 1/5
Dechloro Ethylcloprostenolamide is used in very small concentrations, has a lightweight molecular structure and is typically delivered in water-based or silicone-light formulas rather than heavy oils, all of which keep its pore-clogging potential low. It is therefore unlikely to block follicles or worsen existing blemishes.
Suitability: generally fine for acne-prone or breakout-prone users.
Because most lash and brow serums are applied to a limited area rather than the full face, real-world exposure for acneic skin is minimal, which further reduces any risk of congestion.
Summary
Dechloro Ethylcloprostenolamide is a lab-made prostaglandin analogue that works primarily as a hair conditioning agent, helping lashes, brows and scalp hair look thicker, softer and shinier by smoothing the cuticle and improving flexibility. It does this through its affinity for the hair shaft, where its hydroxyl groups attract moisture and its lipid-friendly backbone forms a light protective film.
The ingredient sits in a niche corner of the beauty market, appearing mostly in specialty lash and brow enhancers rather than mainstream shampoos or conditioners. While not a household name, it has a loyal following among users seeking fuller-looking lashes without prescription products.
Topically it is considered low risk when used as directed, though prostaglandin analogues can trigger irritation or pigment changes in a small percentage of users. As with any new cosmetic it is wise to do a patch test on a discreet area before regular use, especially if you have sensitive skin or a history of reactions.