Diaminohexyl Trihydroxybenzamide Hcl: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Diaminohexyl Trihydroxybenzamide Hcl?

Diaminohexyl Trihydroxybenzamide HCl is a lab-made antioxidant that comes from a trihydroxybenzamide base joined to a six-carbon diamino chain, then finished as a hydrochloride salt for stability and easy mixing with water. It does not occur in nature; chemists create it through a controlled reaction that joins trihydroxybenzoic acid with hexamethylenediamine, followed by purification and neutralization with hydrochloric acid. The ingredient first appeared in skin care research aimed at shielding skin from pollution-related stress, and formulators soon adopted it for its strong protective power at low use levels. Today you will spot it in lightweight serums, anti-aging creams, sheet masks, after-sun lotions and targeted treatments that promise to keep skin looking fresh and even toned.

Diaminohexyl Trihydroxybenzamide Hcl’s Cosmetic Benefits/Uses

This ingredient serves one key role: it acts as an antioxidant. In a formula it hunts down free radicals produced by sunlight, smoke and daily grime before they can break down skin lipids and collagen. By stopping this chain reaction it helps keep skin feeling firm and healthy while also guarding the product itself from color change or scent shift, which helps extend shelf life and maintain performance from the first pump to the last.

Who Can Use Diaminohexyl Trihydroxybenzamide Hcl

Thanks to its light molecular weight and water solubility this antioxidant plays nicely with nearly every skin type. Oily and combination complexions appreciate that it sinks in fast without leaving residue while dry or mature skin enjoys the extra free-radical defense layered under richer creams. Sensitive skin generally tolerates it because it lacks fragrance oils and known sensitizers though anyone with a history of reacting to amide or amine compounds should stay alert for redness or itching.

The ingredient is fully synthetic so no animal-derived substances are involved in its creation or purification making it suitable for vegans and vegetarians. The hydrochloride salt is produced through standard mineral acid neutralization rather than using animal proteins as catalysts.

Current research shows no hormonal activity or penetration deep enough to raise concern for pregnant or breastfeeding women when used at the tiny percentages found in cosmetics. That said this is not medical advice and anyone who is expecting or nursing should run the product past a healthcare professional just to be safe.

Diaminohexyl Trihydroxybenzamide HCl does not increase skin’s sensitivity to sunlight so there is no added risk of sunburn. Of course daily sunscreen is still a smart habit whenever you use any antioxidant to get the most protection from UV damage.

Potential Side Effects/Adverse Reactions

Reactions to topical Diaminohexyl Trihydroxybenzamide HCl differ from one person to another. The points below outline possible but uncommon side effects assuming the product has been made and stored correctly most users will not notice any of these issues.

  • Transient stinging or warmth right after application this usually fades within a few minutes as the pH levels out on the skin
  • Mild redness or flushing in very sensitive skin often linked to overuse or pairing with other strong actives
  • Dry patches if the formula lacks sufficient humectants or emollients to balance the antioxidant
  • Contact dermatitis an allergic-type response that may include itching bumps or swelling

If you experience any of these symptoms stop using the product immediately and consult a dermatologist or healthcare provider for guidance.

Comedogenic Rating

Rating: 0 / 5

Diaminohexyl Trihydroxybenzamide HCl is water soluble, used at very low levels and lacks heavy oils or waxes that can block pores. Its small size lets it rinse away easily during cleansing so it does not linger inside follicles. Because it is an antioxidant rather than an emollient or thickening agent it has virtually no tendency to trap sebum or dead skin cells.

Suitable for acne-prone or breakout-prone skin.

No notable interactions with typical acne treatments such as benzoyl peroxide or salicylic acid have been reported so it can be layered in most routines without raising clogging risk.

Summary

Diaminohexyl Trihydroxybenzamide HCl is a lab crafted antioxidant that neutralises free radicals created by UV light pollution and daily stress. By stopping those unstable molecules it helps preserve collagen lipids and overall skin tone while also protecting the formula from spoilage.

Although effective it is still a niche ingredient seen mainly in forward thinking serums masks and anti aging creams rather than mass market moisturisers. Formulators value its stability in water based systems but consumer awareness is modest compared with big names like vitamin C.

Current research places it in the low risk category for irritation or systemic effects when used as directed. As with any new skincare step a brief patch test on clean skin helps confirm personal tolerance before full face use.

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