Dihydromyricetin: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Dihydromyricetin?

Dihydromyricetin is a plant derived compound that belongs to the flavonoid family, a group of natural antioxidants found in many fruits and leaves. It is often extracted from the bark and leaves of the Ampelopsis grossedentata plant, sometimes called vine tea, which grows in parts of Asia. Chemically it is made up of several hydroxyl groups attached to a benzopyran backbone, giving it water friendly properties and a mild yellow tint.

Traditional herbal drinks that included this plant date back centuries, yet its use in beauty products is fairly recent. When researchers noticed its ability to soothe and protect plant tissues they began testing it on skin, leading to its adoption by cosmetic chemists in the last two decades.

To create cosmetic grade dihydromyricetin manufacturers usually start with dried plant material, treat it with food grade solvents to pull out the active compound, then filter, concentrate and purify it through crystallization. The final powder is standardized so each batch offers the same level of activity.

You will most often see dihydromyricetin in lightweight serums, hydrating toners, sheet masks, after sun gels, anti aging creams and calming spot treatments. Its gentle nature makes it a good partner for both leave on and rinse off formulas where a non greasy finish is desired.

Dihydromyricetin’s Cosmetic Benefits/Uses

In skin care dihydromyricetin is valued mainly for one key job that supports a healthy looking complexion. As a skin conditioning agent it helps soften skin surface proteins, boost moisture retention and reduce the feeling of roughness. When added to a formula it can leave skin feeling smoother and more comfortable while lending a light protective veil that works well under makeup or sunscreen.

Who Can Use Dihydromyricetin

Dihydromyricetin is gentle enough for most skin types including dry, normal, combination and oily. Its water friendly structure means it hydrates without leaving a heavy film, making it a welcome choice for those prone to clogged pores or excess shine. Sensitive skin usually tolerates it well because it lacks common irritants like fragrances and strong acids. There are no known reasons for extremely dry or compromised barrier skin to avoid it although pairing it with a richer moisturizer may be needed for extra nourishment.

The ingredient comes from a plant source and the extraction process does not involve animal by-products so it is suitable for vegans and vegetarians. Products that feature it are often positioned as clean or botanical but checking the full ingredient list is still wise if you follow a strict lifestyle standard.

No specific warnings have been issued for pregnant or breastfeeding women regarding topical dihydromyricetin. Current research has not flagged hormone interference or systemic absorption at levels used in cosmetics. That said this is not medical advice and anyone who is expecting or nursing should discuss every skincare product with a healthcare professional to be safe.

Dihydromyricetin does not appear to increase photosensitivity. It actually shows mild antioxidant activity that may complement daytime sun protection though it is not a substitute for SPF. As with any new active paying attention to how your skin responds over the first few uses is a smart approach.

Potential Side Effects/Adverse Reactions

Responses to topical dihydromyricetin differ from person to person. The issues listed below are only potential side effects and most users will not encounter them if the product has been formulated and preserved correctly.

  • Mild redness or warmth right after application
  • Temporary stinging on abraded or freshly exfoliated skin
  • Rare allergic contact dermatitis for individuals sensitive to flavonoids
  • Interaction with high levels of alcohol in a formula leading to dryness

If you notice persistent irritation discontinue use and consult a dermatologist or healthcare provider for guidance.

Comedogenic Rating

Rating: 0

Dihydromyricetin is fully water soluble and contains no heavy oils or waxes that can lodge in pores so it is considered non comedogenic. It is used at low levels in light textures like serums and toners and rinses away easily during normal cleansing, keeping pore blockage risk minimal.

That makes it well suited to skin that is prone to acne or frequent breakouts.

Because it tends to be combined with other low clogging ingredients it rarely pushes up the overall comedogenic load of a finished product.

Summary

Dihydromyricetin is a plant derived flavonoid that conditions skin by softening surface proteins, drawing in moisture and forming a light soothing veil. These actions leave skin feeling smoother more supple and comfortably hydrated.

Although not as famous as hyaluronic acid or niacinamide its quiet effectiveness is earning it a place in modern formulas especially in Asia and among brands seeking gentle botanical actives.

Available research points to a strong safety profile with low chances of irritation or allergy. Even so it is smart to run a quick patch test whenever you introduce a new product containing this ingredient to confirm personal tolerance.

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