Dihydroquercetin Dithiolanepentyl Ether: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Dihydroquercetin Dithiolanepentyl Ether?

Dihydroquercetin Dithiolanepentyl Ether is a lab-crafted derivative of dihydroquercetin, a naturally occurring flavonoid most often sourced from larch wood, citrus peels and onions. Chemists attach a small five-carbon dithiolane ring and a pentyl chain to the original antioxidant molecule, turning it into an oil-soluble ether that stays stable in creams and lotions far longer than raw plant extracts. This stability was the main reason skin care researchers began experimenting with it in the early 2000s while searching for plant-based antioxidants that would resist heat, light and oxygen inside a cosmetic jar.

Manufacturing begins with purified dihydroquercetin obtained through water or ethanol extraction. The flavonoid then undergoes a controlled reaction with a dithiolanepentyl reagent in the presence of mild catalysts. The result is a pale yellow oily liquid that blends smoothly into both water-in-oil and oil-in-water emulsions without altering their texture or scent.

You are most likely to find Dihydroquercetin Dithiolanepentyl Ether in facial serums, anti-aging lotions, hydrating sheet masks, soothing after-sun gels, lip balms, hand creams and specialty treatments aimed at dull or stressed skin.

Dihydroquercetin Dithiolanepentyl Ether’s Cosmetic Benefits/Uses

This multi-tasking ingredient brings several helpful actions to a cosmetic formula

  • Antioxidant – helps neutralize free radicals created by UV light and pollution which may in turn reduce the look of premature lines and uneven tone
  • Humectant – draws water toward the upper layers of skin so the surface feels fresher and looks plumper throughout the day
  • Skin Conditioning – softens rough patches and enhances overall smoothness leaving skin feeling comfortable
  • Emollient – supplies a light oily feel that fills in microscopic gaps between skin cells giving a supple touch without heaviness

Who Can Use Dihydroquercetin Dithiolanepentyl Ether

This ingredient suits most skin types including oily, combination, dry and sensitive skins because it delivers lightweight moisture while calming surface stress. Its oil-soluble form lets it sink in without clogging pores so even acne-prone users usually do well with it. People with known sulfur allergies should proceed cautiously because the molecule contains a small sulfur ring that could trigger sensitivity in rare cases.

Dihydroquercetin Dithiolanepentyl Ether is synthesized from plant-derived flavonoids and contains no animal derivatives so it is appropriate for vegans and vegetarians.

There is no published evidence showing harm to pregnant or breastfeeding women when the ingredient is used at standard cosmetic levels. This is not medical advice and anyone who is pregnant or nursing should review all skincare choices with a qualified healthcare provider to be safe.

The compound does not absorb UV light and does not raise the risk of photosensitivity. It can be worn day or night under sunscreen without special precautions.

Potential Side Effects/Adverse Reactions

Responses to topical Dihydroquercetin Dithiolanepentyl Ether vary from one person to another. The points below outline potential side effects yet most users will not encounter them when the ingredient is properly formulated in a finished product.

  • Mild redness or warmth
  • Transient stinging on very compromised or freshly exfoliated skin
  • Allergic contact dermatitis in individuals sensitive to flavonoids or sulfur-containing compounds
  • Rare clogging if used in heavy occlusive balms on extremely oily skin

If you experience any uncomfortable reaction discontinue use and consult a medical professional.

Comedogenic Rating

Rating: 1/5

Dihydroquercetin Dithiolanepentyl Ether is an oil-soluble molecule but it is lightweight and absorbs quickly, leaving minimal residue on the skin surface. It does not form a heavy occlusive film and its molecular size is small enough to avoid sitting in pores yet large enough not to penetrate sebaceous ducts. These features keep the likelihood of pore blockage low, earning it a rating of 1.

Suitable for acne-prone and breakout-prone skin when used in typical cosmetic concentrations.

Formulas that pair the ingredient with thick waxes or butters could shift the overall product toward the heavier side which may raise clogging risk, so always consider the full ingredient list.

Summary

Dihydroquercetin Dithiolanepentyl Ether works as an antioxidant, humectant, skin-conditioning and emollient agent. Its flavonoid backbone donates electrons to neutralize free radicals while the modified dithiolane and pentyl chain help it dissolve into oils and attract moisture, leaving skin smoother and more supple.

Though not as famous as vitamin C or niacinamide, it is gaining traction in niche serums and masks for people seeking plant-derived antioxidants that stay stable in modern formulas.

Current research and usage data point to a high safety margin with only rare reports of irritation or allergy. As with any new skincare ingredient, patch testing a fresh product on a small area for a few days is a smart way to confirm personal tolerance.

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