Dihydroquercetin Glucoside: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
Share:
Inside this article:

We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Dihydroquercetin Glucoside?

Dihydroquercetin Glucoside is a plant-derived compound created when glucose, a simple sugar, is bound to dihydroquercetin, a flavonoid naturally present in sources like larch trees and certain fruits. The glucose attachment improves the flavonoid’s stability and makes it easier to dissolve in water, qualities prized in modern skin care formulas. Interest in the molecule grew in the early 2000s when researchers looked for gentler plant antioxidants that would stay effective after long periods on store shelves. Cosmetic chemists learned to produce it by starting with purified dihydroquercetin extracted from wood or fruit pulp, then using an enzymatic or catalytic process to link a glucose unit to the flavonoid. The finished ingredient is a fine, pale powder that blends smoothly into water-based or emulsified products.

Today you will most often see Dihydroquercetin Glucoside in serums, daily moisturizers, sheet masks, eye creams and anti-aging concentrates aimed at brightening the skin and protecting it from environmental stress.

Dihydroquercetin Glucoside’s Cosmetic Benefits/Uses

In topical products this ingredient delivers two main advantages:

  • Antioxidant: Helps neutralize free radicals generated by sunlight, pollution and natural skin processes. By reducing oxidative stress it supports a fresher, more even-toned complexion and can slow the look of premature aging.
  • Skin conditioning: Aids in maintaining a soft, smooth skin feel. Its water-binding ability supports lasting hydration which can make fine lines appear less noticeable.

Who Can Use Dihydroquercetin Glucoside

This antioxidant is gentle enough for virtually all skin types. Its lightweight water soluble nature means it will not clog pores so oily and acne prone users can apply it without fear of extra breakouts, while its soothing profile makes it a good fit for dry or sensitive complexions as well. Only individuals with a known allergy to larch tree derivatives or related flavonoids may need to steer clear.

The ingredient is derived entirely from plant sources and the enzymatic process used to attach glucose relies on microbial or plant based catalysts, making it suitable for both vegans and vegetarians.

No studies have flagged dihydroquercetin glucoside as unsafe for women who are pregnant or breastfeeding and it is not known to penetrate deeply enough to reach the bloodstream. Still this is not medical advice; anyone who is pregnant or nursing should run any new skincare product past a qualified healthcare professional just to be safe.

Unlike exfoliating acids or retinoids this molecule does not increase photosensitivity. It can actually complement daily sunscreen use by adding antioxidant support against UV triggered free radicals.

Potential Side Effects/Adverse Reactions

Reactions to topical dihydroquercetin glucoside vary from person to person. The points below outline potential side effects but they are uncommon and most users experience none when the ingredient has been properly formulated.

  • Mild redness or stinging immediately after application especially on freshly exfoliated skin
  • Localized dryness if the finished product contains high levels of alcohol alongside the ingredient
  • Contact allergy leading to itching bumps or a rash in people sensitive to larch derived flavonoids
  • Light discoloration of very pale creams over time which may indicate lowered antioxidant activity rather than a true skin reaction

If you experience any adverse effect stop using the product and consult a healthcare professional or dermatologist.

Comedogenic Rating

Rating: 0/5 – Dihydroquercetin Glucoside is fully water soluble and contains no oily or waxy residues that could block pores. It stays suspended in the water phase of a formula so it rinses or absorbs without leaving a film on the skin. This makes it suitable for those who are prone to acne or frequent breakouts. As with any single component the overall comedogenicity of a finished product depends on the other ingredients and the final texture, but this molecule itself is considered non-pore-clogging.

Summary

Dihydroquercetin Glucoside acts primarily as an antioxidant and skin conditioning agent. The attached glucose keeps the flavonoid stable and water friendly, allowing it to mop up free radicals on the skin surface while also binding moisture for a smoother feel. Although not yet a household name it has been gaining quiet traction in serums and lightweight moisturizers that aim to brighten and protect without heavy oils. Available research and market use show it to be very safe with only rare cases of sensitivity. As with any new cosmetic ingredient it is smart to perform a quick patch test when adding a product that contains it so you can rule out individual reactions before applying it regularly.

Was this article helpful?
More from Glooshi:
ADVERTISEMENT
Get all our top headlines in beauty.
Delivered right to your inbox each week. Zero spam, all goodness, opt-out at anytime.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Get the latest beauty news, top product recommendations & brand-exclusive discount codes direct to your inbox.
Send good feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Send bad feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Search